Protein Overview: HGH1

General Information:
Name(s) found:	HGH1 / YGR187C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321626\|ref\|NP_011703.1\| Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm; Hgh1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64505 HGH1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1708196\|sp\|P48362.2\|HGH1_YEAST RecName: Full=Protein HGH1 [NCBI NR] gi\|1430953\|emb\|CAA67531.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1323332\|emb\|CAA97213.1\| HGH1 [Saccharomyces cerevisiae] [NCBI NR] Protein HGH1 OS=Saccharomyces cerevisiae GN=HGH1 PE=1 SV=2 [Swiss-Prot] HGH1 Protein of unknown function [mips] Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16) [SGD] HGH1, Chr VII from 870227-871411, reverse complement [yeast_orfs2] Chr VII from 870227-871411, reverse complement [yeastorf3.fasta] Chr VII from 870234-871418, reverse complement [yeastorf4.fasta] Chr VII from 871418-870234, reverse complement [yeastorf5.fasta] (P48362) HGH1 protein [4932.FASTACCERV.txt] HGH1 SGDID:S0003419, Chr VII from 871419-870235, reverse complement, Verified ORF [yeastflysequest.fasta] HGH1 SGDID:S0003419, Chr VII from 871421-870237, reverse complement, Verified ORF [10112005cervSGD.fasta] Hgh1p [Saccharomyces cerevisiae]gi\|1323332\|emb\|CAA97213.1\| HGH1 [Saccharomyces cerevisiae]gi\|1430953\|emb\|CAA67531.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2131278\|pir\|\|S64505 HGH1 protein - yeast (Saccharomyces cerevisiae)gi\|1708196\|sp\| [nrdb_11152004_Chlamydomonas] HGH1 SGDID:S000003419, Chr VII from 871421-870237, reverse complement, Verified ORF, "Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HGH1 SGDID:S000003419, Chr VII from 871421-870237, reverse complement, Verified ORF, "Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] HGH1 SGDID:S000003419, Chr VII from 871421-870237, reverse complement, Verified ORF, "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; sim [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta] HGH1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasm; Hgh1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein HGH1 [nr-271106-contam.fasta] HGH1 SGDID:S000003419, Chr VII from 871421-870237, reverse complement, Verified ORF, "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)" [scerevisihumanrev.fasta] [chemostatdb.fasta] FAM203 family protein HGH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HGH1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HGH1 SGDID:S000003419, Chr VII from 871416-870232, Genome Release 64-1-1, reverse complement, Verified ORF, "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)" [yeast-030211-contam.fasta] HGH1 SGDID:S000003419, Chr VII from 871416-870232, Genome Release 64-2-1, reverse complement, Verified ORF, "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress" [20141208_orf_trans.fasta] YGR187C SGDID:S000003419, Chr VII from 871416-870232, Genome Release 64-1-1, reverse complement, Verified ORF, "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] Protein HGH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HGH1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
Organism:	Saccharomyces cerevisiae
Length:	394 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	ribosome biogenesis [RCA]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSQLNELVE FLHSPQPAVR QIAIDNLVGF SAGPTSKVFK NDSYRPIKDI IKMIMDPEHG  60
   61 TRVIIQQGVT ILVNLSEDKL VRNIILSDDK KFLKFLVWKI VDLTNPNADI MCILLSNLAK 120
  121 DDGILAVLNI KRNSSGEEVD DGLKLAALNK EVFKSLRAMD CLMDCFVKGY DKKLTKYASF 180
  181 NYLAFFFADI SRFKLGRMYF IEEQEYDGVV PISKLLVFTE KYDAKVRREG VASTIKNSLF 240
  241 DSETHERLLK DEKINLLPYI LLPIASAKDS EIDEEDMFNL PDELQLLPED KERDPIPAII 300
  301 CCHLESILLL CTTHAGREYL RDKSVYPLVR ELHKNVENED IGELCYRIVN MLMRGEPGAG 360
  361 AVEEMPSKNA EEEEEEESEE EEDDDEEDEI VEVA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		AIM22 DPH1 DPH2 EFT2, EFT1 HGH1 MNN1 PGI1 RRG10 TRX1 YMR315W
View Details	Gavin AC, et al. (2006)		EFT2, EFT1 HGH1
View Details	Gavin AC, et al. (2002)		CNS1 HGH1
View Details	Ho Y, et al. (2002)		CCT5 CCT6 CFT1 HGH1 PFS2 TCP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB	Keck JM, et al. (2011)
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPP382	HGH1	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HGH1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..136]	ORFEUS	10.28	beta-Catenin
2	View Details	[137..283]	ORFEUS	10.28	beta-Catenin
3	View Details	[284..394]	ORFEUS	10.28	beta-Catenin

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2