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Protein Overview: PHB1

General Information:
Name(s) found: PHB1 / YGR132C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 287 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of proteolysis [IMPLink to PubMed article][IPILink to PubMed article]
    protein folding [IDALink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]
    replicative cell aging [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSAKLIDV ITKVALPIGI IASGIQYSMY DVKGGSRGVI FDRINGVKQQ VVGEGTHFLV  60
   61 PWLQKAIIYD VRTKPKSIAT NTGTKDLQMV SLTLRVLHRP EVLQLPAIYQ NLGLDYDERV 120
  121 LPSIGNEVLK SIVAQFDAAE LITQREIISQ KIRKELSTRA NEFGIKLEDV SITHMTFGPE 180
  181 FTKAVEQKQI AQQDAERAKF LVEKAEQERQ ASVIRAEGEA ESAEFISKAL AKVGDGLLLI 240
  241 RRLEASKDIA QTLANSSNVV YLPSQHSGGG NSESSGSPNS LLLNIGR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ANP1 MNN10 MNN11 MNN9 PHB1 PHB2
    View Details Gavin AC, et al. (2002) ARO1 ARX1 EMP24 ERP1 ERP2 ERV25 FKS1 HAS1 HHF1, HHF2 KAP123 NIP7 PHB1 RRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PHB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179]
    [208..240]    		 PSI-BLAST 877.529817 No description for 1lu7A_ was found.
    2 View Details [180..207]
    [241..287]    		 PSI-BLAST 877.529817 No description for 1lu7A_ was found.
    3 View Details [198..287] MSA 3.672997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.10215477176861 bayes_pls_golite062009
  • protein binding
    		•  0.769979871341236 bayes_pls_golite062009
  • structural molecule activity
    		•  0.591437172549816 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle