Protein Overview: PHB1

General Information:
Name(s) found:	PHB1 / YGR132C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321571\|ref\|NP_011648.1\| Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregati [NCBI NR] gi\|45270082\|gb\|AAS56422.1\| YGR132C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64441 prohibitin PHB1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730544\|sp\|P40961.2\|PHB1_YEAST RecName: Full=Prohibitin-1 [NCBI NR] gi\|1323219\|emb\|CAA97145.1\| PHB1 [Saccharomyces cerevisiae] [NCBI NR] (P40961) Prohibitin [Swiss-Prot] Prohibitin-1 OS=Saccharomyces cerevisiae GN=PHB1 PE=1 SV=2 [Swiss-Prot] PHB1 Prohibitin, antiproliferative protein [mips] Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [SGD] PHB1, Chr VII from 755584-756447, reverse complement [yeast_orfs2] Chr VII from 755584-756447, reverse complement [yeastorf3.fasta] Chr VII from 755591-756454, reverse complement [yeastorf4.fasta] Chr VII from 756454-755591, reverse complement [yeastorf5.fasta] PHB1 SGDID:S0003364, Chr VII from 756455-755592, reverse complement, Verified ORF [yeastflysequest.fasta] PHB1 SGDID:S0003364, Chr VII from 756457-755594, reverse complement, Verified ORF [10112005cervSGD.fasta] Phb1p [Saccharomyces cerevisiae]gi\|1323219\|emb\|CAA97145.1\| PHB1 [Saccharomyces cerevisiae]gi\|45270082\|gb\|AAS56422.1\| YGR132C [Saccharomyces cerevisiae]gi\|2133061\|pir\|\|S64441 prohibitin PHB1 - yeast (Saccharomyces cerevisiae)gi\|1730544\|sp\|P40961\|PHB_YE [nrdb_11152004_Chlamydomonas] PHB1 SGDID:S000003364, Chr VII from 756457-755594, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Prohibitin-1 [nr-271106-contam.fasta] PHB1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; Phb1p [Saccharomyces cer [nr-271106-contam.fasta] YGR132C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PHB1 SGDID:S000003364, Chr VII from 756457-755594, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Prohibitin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHB1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PHB1 SGDID:S000003364, Chr VII from 756452-755589, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation" [yeast-030211-contam.fasta] PHB1 SGDID:S000003364, Chr VII from 756452-755589, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)" [20141208_orf_trans.fasta] TR4492\|c0_g1_i1\|g.3180 ORF TR4492\|c0_g1_i1\|g.3180 TR4492\|c0_g1_i1\|m.3180 type:complete len:288 (+) TR4492\|c0_g1_i1:556-1419(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR4414\|c0_g1_i1\|g.2947 ORF TR4414\|c0_g1_i1\|g.2947 TR4414\|c0_g1_i1\|m.2947 type:complete len:288 (+) TR4414\|c0_g1_i1:586-1449(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YGR132C SGDID:S000003364, Chr VII from 756452-755589, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_1818\|g.1119 ORF asmbl_1818\|g.1119 asmbl_1818\|m.1119 type:complete len:288 (+) asmbl_1818:580-1443(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_1773\|g.971 ORF ID=asmbl_1773\|g.971 ID=asmbl_1773\|m.971 type:complete len:288 (+) ID=asmbl_1773:600-1463(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_1823\|g.939 ORF ID=asmbl_1823\|g.939 ID=asmbl_1823\|m.939 type:complete len:288 (+) ID=asmbl_1823:580-1443(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	287 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] mitochondrial inner membrane [IDA ]
Biological Process:	negative regulation of proteolysis [IMP][IPI] protein folding [IDA][IPI][ISS] replicative cell aging [IMP ]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSAKLIDV ITKVALPIGI IASGIQYSMY DVKGGSRGVI FDRINGVKQQ VVGEGTHFLV  60
   61 PWLQKAIIYD VRTKPKSIAT NTGTKDLQMV SLTLRVLHRP EVLQLPAIYQ NLGLDYDERV 120
  121 LPSIGNEVLK SIVAQFDAAE LITQREIISQ KIRKELSTRA NEFGIKLEDV SITHMTFGPE 180
  181 FTKAVEQKQI AQQDAERAKF LVEKAEQERQ ASVIRAEGEA ESAEFISKAL AKVGDGLLLI 240
  241 RRLEASKDIA QTLANSSNVV YLPSQHSGGG NSESSGSPNS LLLNIGR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ANP1 MNN10 MNN11 MNN9 PHB1 PHB2
View Details	Gavin AC, et al. (2002)		ARO1 ARX1 EMP24 ERP1 ERP2 ERV25 FKS1 HAS1 HHF1, HHF2 KAP123 NIP7 PHB1 RRP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#14 Mitotic Prep2-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#16 Mitotic-New search criteria	Keck JM, et al. (2011)
View Run	None Entered	#18 Mitotic Prep4-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	PHB1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..179] [208..240]	PSI-BLAST	877.529817	No description for 1lu7A_ was found.
2	View Details	[180..207] [241..287]	PSI-BLAST	877.529817	No description for 1lu7A_ was found.
3	View Details	[198..287]	MSA	3.672997	View MSA. No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.81

Protein Overview: PHB1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: