YRC Public Data Repository - Protein Structure Prediction

Protein:	PHB1
Organism:	Saccharomyces cerevisiae
Length:	287 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHB1.

Description	E-value	Query Range	Subject Range
PHB_RAT - Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1 tr\|G3HJP6\|G3HJP6... - Prohibitin OS=Cricetulus griseus GN=I79_010895 PE=4 SV=1 PHB_MOUSE - Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1	1.0E-71	[4..274]	[2..272]
gi\|61362617, gi\|... - gi\|61362624\|gb\|AAX42254.1\| prohibitin [synthetic construct], gi\|61362617\|gb\|AAX42253.1\| prohibitin [... HGNC:8912\|MIM:17... - null PHB - prohibitin PHB_BOVIN - Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1 gi\|158906128, gi... - gi\|160333845\|ref\|NP_001103918.1\| prohibitin [Felis catus], gi\|158906128\|gb\|ABW82705.1\| prohibitin [F... gi\|158442066, gi... - gi\|158819069\|ref\|NP_001103649.1\| prohibitin [Canis lupus familiaris], gi\|158442066\|gb\|ABW38778.1\| pr... gi\|109114258, gi... - gi\|109114260\|ref\|XP_001093569.1\| PREDICTED: similar to prohibitin isoform 7 [Macaca mulatta], gi\|109... ENSCJAT00000014086 - null gi\|114666273, gi... - gi\|55646807\|ref\|XP_511949.1\| PREDICTED: prohibitin isoform 7 [Pan troglodytes], gi\|114666277\|ref\|XP_...	2.0E-71	[4..274]	[2..272]
gi\|220944624, gi... - gi\|220954406\|gb\|ACL89746.1\| l(2)37Cc-PA [synthetic construct], gi\|220944624\|gb\|ACL84855.1\| l(2)37Cc-... gi\|190657476, gi... - gi\|194879728\|ref\|XP_001974289.1\| GG21649 [Drosophila erecta], gi\|190657476\|gb\|EDV54689.1\| GG21649 [D... l(2)37Cc-PA, l(2... - The gene lethal (2) 37Cc is referred to in FlyBase by the symbol Dmel\l(2)37Cc (CG10691, FBgn0002031... gi\|194134208, gi... - gi\|195345029\|ref\|XP_002039078.1\| GM17028 [Drosophila sechellia], gi\|194134208\|gb\|EDW55724.1\| GM17028... gi\|195484379, gi... - gi\|195484379\|ref\|XP_002090669.1\| GE12669 [Drosophila yakuba], gi\|194176770\|gb\|EDW90381.1\| GE12669 [D... gi\|194191900, gi... - gi\|195580095\|ref\|XP_002079891.1\| GD21777 [Drosophila simulans], gi\|194191900\|gb\|EDX05476.1\| GD21777 ...	2.0E-68	[4..274]	[2..272]
PHB1 - Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane ... PHB1_YEAST - Prohibitin-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHB1 PE=1 SV=2 gi\|207345078 - gi\|207345078\|gb\|EDZ72016.1\| YGR132Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190406850 - gi\|190406850\|gb\|EDV10117.1\| prohibitin [Saccharomyces cerevisiae RM11-1a]	6.0E-67	[1..287]	[1..287]
PHB4_ARATH - Prohibitin-4, mitochondrial OS=Arabidopsis thaliana GN=PHB4 PE=1 SV=1	3.0E-66	[4..272]	[7..275]
gi\|2055454 - gi\|2055454\|gb\|AAB53231.1\| prohibitin-like molecule TC-PRO-1 [Toxocara canis]	2.0E-63	[1..274]	[1..274]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-63	[1..270]	[1..273]
gi\|238014248, gi... - gi\|7716458\|gb\|AAF68385.1\|AF236369_1 prohibitin [Zea mays], gi\|238014248\|gb\|ACR38159.1\| unknown [Zea ...	7.0E-62	[1..270]	[1..273]

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Predicted Domain #1

Region A:
Residues: [1-179]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSAKLIDV ITKVALPIGI IASGIQYSMY DVKGGSRGVI FDRINGVKQQ VVGEGTHFLV  60
   61 PWLQKAIIYD VRTKPKSIAT NTGTKDLQMV SLTLRVLHRP EVLQLPAIYQ NLGLDYDERV 120
  121 LPSIGNEVLK SIVAQFDAAE LITQREIISQ KIRKELSTRA NEFGIKLEDV SITHMTFGP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [208-240]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERQASVIRAE GEAESAEFIS KALAKVGDGL LLI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	877.529817
Match:	1lu7A_
Description:	No description for 1lu7A_ was found.

Predicted Domain #2

Region A:
Residues: [180-207]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFTKAVEQKQ IAQQDAERAK FLVEKAEQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [241-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRLEASKDIA QTLANSSNVV YLPSQHSGGG NSESSGSPNS LLLNIGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	877.529817
Match:	1lu7A_
Description:	No description for 1lu7A_ was found.

Predicted functions:

Term	Confidence	Notes
binding	2.10215477176861	bayes_pls_golite062009
protein binding	0.769979871341236	bayes_pls_golite062009
structural molecule activity	0.591437172549816	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [198-287]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKFLVEKAEQ ERQASVIRAE GEAESAEFIS KALAKVGDGL LLIRRLEASK DIAQTLANSS  60
   61 NVVYLPSQHS GGGNSESSGS PNSLLLNIGR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: