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Protein Overview: SLD3

General Information:
Name(s) found: SLD3 / YGL113W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 668 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [IDALink to PubMed article]
    Biological Process: DNA replication initiation [IMPLink to PubMed article][IPILink to PubMed article]
    DNA unwinding involved in replication [IMPLink to PubMed article]
    Molecular Function: chromatin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METWEVIASV KEATKGLDLS LDHPLIIKSE DVPSNILQLL QQKNRRQLKH ICMKSRKEYF  60
   61 LLEEYGPGFW VKWPYNYFNG YSLPERRTEV VTTVERERAK RETLKTWDEL KFKELLHLWS 120
  121 EEPKGSCKLE KDKDLKLDMN PPDMKGESKI NDYYSDPKEY IESKYYDALF SIHTPLAYFV 180
  181 KSNLVRLKNT CRTKYGSDSY KIAYQAMLQK FLLSIVQFKD RHDNRLLLEP FSSPIADEKR 240
  241 KNCLTKFVIQ DENKNSSTIA DLCVVLKSRE IKLQILLLLE IIGLNDLDWN FRDFEKKYKL 300
  301 KLKKRSLNLT KKGLVRRRSK KKTSEKDKGI ERITTSLDYC EQLDLYLDRA CILDILLSSE 360
  361 TPNPDAIEAS NGTIQEHKKN ILDKSKEASL VGFINYVLIP YFNKKVPHAV EFIIQKLKGP 420
  421 SMRPKRALKK VNDSTNVSSP NTVETYNRLS TSQRASRSSI INSVPSSPAL RRVDANLFSR 480
  481 KSIASPTPEL LNSRTNSNLN EFLESETRSL KRPSQLGRTK SDLTMNHLQK RQFSVSDLST 540
  541 TRVPNSSTIT LKTPFSHSTI NAYKTMNNSF RRVGKRKDIN ETIRLHERVD SEENVQVQAT 600
  601 PAVKKRTVTP NKKAQLQSII ESPLNFKDDD THEGRKNTSN ITSTPTNKPP ENSSKRRVRR 660
  661 RLFAPEST

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC45 CDC6 DPB11 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SLD3
    View Details Krogan NJ, et al. (2006) RIM4 SLD3
    View Details Qiu et al. (2008) ABF1 CDC45 CLF1 DPB11 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCC1 POB3 RAP1 SLD3 TBF1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ELM1 SLD3 1 Unpublished Fields Lab Data
    View Screen CTF13 SLD3 1 Unpublished Fields Lab Data
    View Screen MLC1 SLD3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SLD3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..490] deduced N/A No confident structure predictions are available.
    2 View Details [491..668] MSA 1.003931 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle