Protein Overview: VPS73

General Information:
Name(s) found:	VPS73 / YGL104C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321334\|ref\|NP_011411.1\| Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; Vps73p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64111 probable membrane protein YGL104c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723898\|sp\|P53142.1\|VPS73_YEAST RecName: Full=Vacuolar protein sorting-associated protein 73 [NCBI NR] gi\|1322646\|emb\|CAA96811.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P53142) Probable metabolite transport protein YGL104C [Swiss-Prot] Vacuolar protein sorting-associated protein 73 OS=Saccharomyces cerevisiae GN=VPS73 PE=1 SV=1 [Swiss-Prot] VPS73 Protein involved in vacuolar protein sorting [mips] Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family [SGD] YGL104C, Chr VII from 308711-310171, reverse complement [yeast_orfs2] Chr VII from 308711-310171, reverse complement [yeastorf3.fasta] Chr VII from 308714-310174, reverse complement [yeastorf4.fasta] Chr VII from 310174-308714, reverse complement [yeastorf5.fasta] VPS73 SGDID:S0003072, Chr VII from 310174-308714, reverse complement, Verified ORF [yeastflysequest.fasta] VPS73 SGDID:S0003072, Chr VII from 310176-308716, reverse complement, Verified ORF [10112005cervSGD.fasta] Vps73p [Saccharomyces cerevisiae]gi\|1322646\|emb\|CAA96811.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1723898\|sp\|P53142\|YGK4_YEAST Probable metabolite transport protein YGL104Cgi\|2132546\|pir\|\|S64111 probable membrane protein YGL104c - yeast [nrdb_11152004_Chlamydomonas] VPS73 SGDID:S000003072, Chr VII from 310176-308716, reverse complement, Verified ORF, "Mitochondrial protein of unknown function involved in vacuolar protein sorting" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] VPS73 SGDID:S000003072, Chr VII from 310176-308716, reverse complement, Verified ORF, "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Vacuolar protein sorting-associated protein 73 [nr-271106-contam.fasta] Mitochondrial protein of unknown function involved in vacuolar protein sorting; Vps73p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Vacuolar protein sorting-associated protein 73 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS73 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] VPS73 SGDID:S000003072, Chr VII from 310173-308713, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family" [yeast-030211-contam.fasta] VPS73 SGDID:S000003072, Chr VII from 310173-308713, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YGL104C SGDID:S000003072, Chr VII from 310173-308713, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	486 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ]
Biological Process:	protein targeting to vacuole [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRILSSASL LSNVSMPRQN KHKITKALCY AIIVASIGSI QFGYHLSELN APQQVLSCSE  60
   61 FDIPMEGYPY DRTWLGKRGY KQCIPLNDEQ IGIVTSVFCI GGILGSYFAT SLANIYGRKF 120
  121 SSLINCTLNI VGSLIIFNSN SYRGLIIGRI LVGISCGSLI VIIPLFIKEV APSGWEGLLG 180
  181 SMTQICIRLG VLLTQGIALP LTDSYRWRWI LFGSFLIAVL NFFMWFIVDE SPKWLLAHGR 240
  241 VTDAKLSLCK LRGVTFDEAA QEIQDWQLQI ESGDPLIEPT TTNSISGSNS LWKYLRDRTN 300
  301 VKSRHVITVL LFGQQFCGIN SIVLYGTKII SQLYPQHAIR INFFISMVNV LVTILVSLLI 360
  361 HSLPRKPLLM TSTVLVSVTA FIMGIAMNHN KMNLLIVFSF IYMGVFTMGL NPLPFIIMRE 420
  421 VSKPQDMVLA QRYGTICNWV GTFIIAYTFP IIHDVLSGYV FIIFAIIACS ISAFIWKKVP 480
  481 ETKRSG

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 ENP2 GDE1 HHF1, HHF2 HOT1 KRI1 MRPL1 NOC3 NOP12 NOP2 NOP7 PDI1 POB3 POL2 PUF6 PWP1 RRP14 RRP5 SFP1 SPT16 SSF1 TIF4631 TRL1 UTP22 VMR1 VPS73 WTM2 YRA1
View Details	Qiu et al. (2008)		AAC3 VPS73 YDL133W YGR149W YOR292C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	VAM7	VPS73	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..229] [276..486]	PSI-BLAST	460.9897	No description for 1ja5A_ was found.
2	View Details	[230..275]	PSI-BLAST	460.9897	No description for 1ja5A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.29248638217469	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.29248638217469	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.6904339767429	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2