Protein Overview: PPZ2

General Information:
Name(s) found:	PPZ2 / YDR436W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|927693\|gb\|AAB64859.1\| Ppz2p: serine/threonine protein phosphatase; YDR436W; CAI: 0.11 [Saccharomyces cerevisiae] [NCBI NR] gi\|6320644\|ref\|NP_010724.1\| Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; Ppz2p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S35674 phosphoprotein phosphatase (EC 3.1.3.16) PPZ2 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|403322\|emb\|CAA52233.1\| serine/threonine specific protein phosphatase [Saccharomyces cerevisiae] [NCBI NR] gi\|1346783\|sp\|P33329.4\|PPZ2_YEAST RecName: Full=Serine/threonine-protein phosphatase PP-Z2 [NCBI NR] Serine/threonine-protein phosphatase PP-Z2 OS=Saccharomyces cerevisiae GN=PPZ2 PE=1 SV=4 [Swiss-Prot] PPZ2 Protein ser/thr phosphatase of the PP-1 family [mips] Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance [SGD] PPZ2, Chr IV from 1334810-1336942 [yeast_orfs2] Chr IV from 1334810-1336942 [yeastorf3.fasta] Chr IV from 1334809-1336941 [yeastorf4.fasta] PPZ2 SGDID:S0002844, Chr IV from 1334809-1336941, Verified ORF [yeastflysequest.fasta] PPZ2 SGDID:S0002844, Chr IV from 1334811-1336943, Verified ORF [10112005cervSGD.fasta] Ppz2p [Saccharomyces cerevisiae]gi\|403322\|emb\|CAA52233.1\| serine/threonine specific protein phosphatase [Saccharomyces cerevisiae]gi\|927693\|gb\|AAB64859.1\| Ppz2p: serine/threonine protein phosphatase; YDR436W; CAI: 0.11 [Saccharomyces cerevisiae]gi\|4221 [nrdb_11152004_Chlamydomonas] PPZ2 SGDID:S000002844, Chr IV from 1334811-1336943, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] PPZ2 SGDID:S000002844, Chr IV from 1334813-1336945, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" [yeast-contam.fasta] PPZ2 SGDID:S000002844, Chr IV from 1334814-1336946, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] serine/threonine specific protein phosphatase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ppz2p: serine/threonine protein phosphatase; YDR436W; CAI: 0.11 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Serine/threonine-protein phosphatase PP-Z2 [nr-271106-contam.fasta] Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; Ppz2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Serine/threonine-protein phosphatase PP-Z2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPZ2 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PPZ2 SGDID:S000002844, Chr IV from 1334821-1336953, Genome Release 64-1-1, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" [yeast-030211-contam.fasta] PPZ2 SGDID:S000002844, Chr IV from 1334821-1336953, Genome Release 64-2-1, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" [20141208_orf_trans.fasta] YDR436W SGDID:S000002844, Chr IV from 1334821-1336953, Genome Release 64-1-1, Verified ORF, "Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	710 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	cellular sodium ion homeostasis [IGI][IMP]
Molecular Function:	protein serine/threonine phosphatase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNSGSKQHT KHNSKKDDHD GDRKKTLDLP PLTKSDTTHS LKSSRSLRSL RSKRSEASLA  60
   61 SNVQAQTQPL SRRSSTLGNG NRNHRRSNNA PITPPNNHYL TSHPSSSRRL SSSSRRSSMG 120
  121 NNNNSELPPS MIQMEPKSPI LKNSTSMHST SSFNSYENAL TDDDDDRGDD GGESPSMAKV 180
  181 TRINTSSSAD RGSKRTPLRR HNSLQPEKGV TGFSSTSSKL RRRSDNTLPA SYPLNAEAGG 240
  241 NGSDYFSNRS NSHASSRKSS FGSTGNTAYS TPLHSPALRK MSSRDNDDSG DNVNGRGTSP 300
  301 IPNLNIDKPS PSASSASKRE YLSAYPTLAH RDSSSSLSPR GKGQRSSSSS SSSQRIYVSP 360
  361 PSPTGDFVHG SCADGDNGSR TNTMVEMKRK KPVRPVDIDE IIQRLLDAGY AAKRTKNVCL 420
  421 KNSEIIQICH KARELFLAQP ALLELSPSVK IVGDVHGQYA DLLRLFTKCG FPPMANYLFL 480
  481 GDYVDRGKQS LETILLLLCY KIKYPENFFL LRGNHECANV TRVYGFYDEC KRRCNIKIWK 540
  541 TFVDTFNTLP LAAIVTGKIF CVHGGLSPVL NSMDEIRHVS RPTDVPDFGL INDLLWSDPT 600
  601 DSSNEWEDNE RGVSFCYNKV AINKFLNKFG FDLVCRAHMV VEDGYEFFND RSLVTVFSAP 660
  661 NYCGEFDNWG AVMTVSEGLL CSFELLDPLD STALKQVMKK GRQERKLANR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		HRT3 PPZ2 SAP155 SDS24 SIT4
View Details	Ho Y, et al. (2002)		GLC7 GLC8 HXT6 KOG1 NET1 NOP6 NSR1 PHO85 PMA1 PMA2 PPZ2 REG1 RSE1 RVB1 SDS22 SNF4 VHS3 YGR130C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ECO1	PPZ2	2	Unpublished Fields Lab Data
View Screen	YJL147C	PPZ2	2	Unpublished Fields Lab Data
View Screen	NPA3	PPZ2	2	Unpublished Fields Lab Data
View Screen	CAB3	PPZ2	2	Unpublished Fields Lab Data
View Screen	SPO21	PPZ2	2	Unpublished Fields Lab Data
View Screen	SPO21	PPZ2	2	Unpublished Fields Lab Data
View Screen	SPO21	PPZ2	2	Unpublished Fields Lab Data
View Screen	SPO21	PPZ2	2	Unpublished Fields Lab Data
View Screen	RPB2	PPZ2	2	Unpublished Fields Lab Data
View Screen	MPC54	PPZ2	2	Unpublished Fields Lab Data
View Screen	YDR413C	PPZ2	2	Unpublished Fields Lab Data
View Screen	ACM1	PPZ2	2	Unpublished Fields Lab Data
View Screen	BRP1	PPZ2	1	Unpublished Fields Lab Data
View Screen	CAB3	PPZ2	1	Hazbun TR, et al. (2003)
View Screen	PEX6	PPZ2	1	Unpublished Fields Lab Data
View Screen	MPD2	PPZ2	1	Unpublished Fields Lab Data
View Screen	FUN19	PPZ2	1	Unpublished Fields Lab Data
View Screen	CDC13	PPZ2	1	Unpublished Fields Lab Data
View Screen	HBT1	PPZ2	1	Unpublished Fields Lab Data
View Screen	RGD2	PPZ2	1	Unpublished Fields Lab Data
View Screen	MRPL51	PPZ2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PPZ2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..326]	ab initio	9.95	No description for 1i3qA was found.
2	View Details	[327..389]	deduced	N/A	No confident structure predictions are available.
3	View Details	[390..710]	PSI-BLAST	1377.0	Protein phosphatase-1 (PP-1)

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2