YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: HIS4

General Information:
Name(s) found: HIS4 / YCL030C [SGD]
Description(s) found:
SHOW ONLY BEST
  • gi|49065653|sp|P00815.3|HIS2_YEAST RecName: Full=Histidine biosynthesis trifunctional protein; Includes: RecName: Full=Phosphoribosyl-AMP cyclohydrolase; Includes: RecName: Full=Phosphoribosyl-ATP pyrophosphohydrolase; Includes: RecName: Full=Histidinol d [NCBI NR]
  • gi|14588907|emb|CAA42355.2| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|10383761|ref|NP_009900.2| Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; Hi [NCBI NR]
  • Histidine biosynthesis trifunctional protein OS=Saccharomyces cerevisiae GN=HIS4 PE=1 SV=3 [Swiss-Prot]
  • HIS4 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase [mips]
  • Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis [SGD]
  • HIS4, Chr III from 65934-68333, reverse complement [yeast_orfs2]
  • Chr III from 65934-68333, reverse complement [yeastorf3.fasta]
  • Chr III from 68333-65934, reverse complement [yeastorf5.fasta]
  • >CAA42355 (CAA42355) Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase [4932.FASTACCERV.txt]
  • HIS4 SGDID:S0000535, Chr III from 68333-65934, reverse complement, Verified ORF [yeastflysequest.fasta]
  • His4p [Saccharomyces cerevisiae]gi|14588907|emb|CAA42355.2| phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase [Saccharomyces cerevisiae]gi|49065653|sp|P00815|HIS2_YEAST Histidine biosynthesis trifunctional pro [nrdb_11152004_Chlamydomonas]
  • (P00815) Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19); Phosphoribosyl-ATP pyrophosphohydrolase (EC 3.6.1.31); Histidinol dehydrogenase (EC 1.1.1.23) (HDH)] [cerv4932.FASTAC]
  • HIS4 SGDID:S000000535, Chr III from 68333-65934, reverse complement, Verified ORF, "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, thi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase/histidinol dehydrogenase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; His4p [Saccharomyces cerevisiae [nr-271106-contam.fasta]
  • Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase ; Phosphoribosyl-ATP pyrophosphohydrolase ; Histidinol dehydrogenase (HDH)] [nr-271106-contam.fasta]
  • HIS4 SGDID:S000000535, Chr III from 68333-65934, reverse complement, Verified ORF, "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Histidine biosynthesis trifunctional protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HIS4 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • HIS4 SGDID:S000000535, Chr III from 68333-65934, Genome Release 64-1-1, reverse complement, Verified ORF, "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis" [yeast-030211-contam.fasta]
  • HIS4 SGDID:S000000535, Chr III from 68333-65934, Genome Release 64-2-1, reverse complement, Verified ORF, "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis" [20141208_orf_trans.fasta]
  • YCL030C SGDID:S000000535, Chr III from 68333-65934, Genome Release 64-1-1, reverse complement, Verified ORF, "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 799 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: histidine biosynthetic process [TASLink to PubMed article]
    Molecular Function: phosphoribosyl-ATP diphosphatase activity [TASLink to PubMed article]
    phosphoribosyl-AMP cyclohydrolase activity [TASLink to PubMed article]
    histidinol dehydrogenase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLPILPLID DLASWNSKKE YVSLVGQVLL DGSSLSNEEI LQFSKEEEVP LVALSLPSGK  60
   61 FSDDEIIAFL NNGVSSLFIA SQDAKTAEHL VEQLNVPKER VVVEENGVFS NQFMVKQKFS 120
  121 QDKIVSIKKL SKDMLTKEVL GEVRTDRPDG LYTTLVVDQY ERCLGLVYSS KKSIAKAIDL 180
  181 GRGVYYSRSR NEIWIKGETS GNGQKLLQIS TDCDSDALKF IVEQENVGFC HLETMSCFGE 240
  241 FKHGLVGLES LLKQRLQDAP EESYTRRLFN DSALLDAKIK EEAEELTEAK GKKELSWEAA 300
  301 DLFYFALAKL VANDVSLKDV ENNLNMKHLK VTRRKGDAKP KFVGQPKAEE EKLTGPIHLD 360
  361 VVKASDKVGV QKALSRPIQK TSEIMHLVNP IIENVRDKGN SALLEYTEKF DGVKLSNPVL 420
  421 NAPFPEEYFE GLTEEMKEAL DLSIENVRKF HAAQLPTETL EVETQPGVLC SRFPRPIEKV 480
  481 GLYIPGGTAI LPSTALMLGV PAQVAQCKEI VFASPPRKSD GKVSPEVVYV AEKVGASKIV 540
  541 LAGGAQAVAA MAYGTETIPK VDKILGPGNQ FVTAAKMYVQ NDTQALCSID MPAGPSEVLV 600
  601 IADEDADVDF VASDLLSQAE HGIDSQVILV GVNLSEKKIQ EIQDAVHNQA LQLPRVDIVR 660
  661 KCIAHSTIVL CDGYEEALEM SNQYAPEHLI LQIANANDYV KLVDNAGSVF VGAYTPESCG 720
  721 DYSSGTNHTL PTYGYARQYS GANTATFQKF ITAQNITPEG LENIGRAVMC VAKKEGLDGH 780
  781 RNAVKIRMSK LGLIPKDFQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
    View Details Gavin AC, et al. (2002) DHH1 HIS4 PDC1 SAM1 TUB3
    View Details Ho Y, et al. (2002) APC2 ARF2 FMP48 HIS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HIS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..55] MSA 3.009987 View MSA. No confident structure predictions are available.
    2 View Details [56..120] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [121..243] Pfam 50.124939 Phosphoribosyl-AMP cyclohydrolase No confident structure predictions are available.
    4 View Details [244..344] Pfam 39.744727 Phosphoribosyl-ATP pyrophosphohydrolase No confident structure predictions are available.
    5 View Details [345..378]
    [593..799]    		 PSI-BLAST 1145.9897 L-histidinol dehydrogenase HisD
    6 View Details [379..592] PSI-BLAST 1145.9897 L-histidinol dehydrogenase HisD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  4.07350794147607 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.83474502448328 bayes_pls_golite062009
  • catalytic activity
    		•  1.02941336036162 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.335226474674779 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.0625072987078716 bayes_pls_golite062009
    4
    Term Confidence Notes
  • phosphoribosyl-ATP diphosphatase activity
    		•  3.62350723585237 bayes_pls_golite062009
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  2.54150905806868 bayes_pls_golite062009
  • catalytic activity
    		•  0.634427093790328 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.324592130011053 bayes_pls_golite062009
    5
    Term Confidence Notes
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  2.32012109012499 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.31275077585879 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.24875477727877 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  2.22720948878196 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle