Protein Overview: CLN3

General Information:
Name(s) found:	CLN3 / YAL040C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis [SGD]
Organism:	Saccharomyces cerevisiae
Length:	580 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA ][IMP]
Biological Process:	vacuole organization [IMP] G1/S transition of mitotic cell cycle [TAS] regulation of cell size [IMP] vacuole fusion, non-autophagic [IDA][IMP] regulation of cyclin-dependent protein kinase activity [TAS]
Molecular Function:	cyclin-dependent protein kinase regulator activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS AKSKNPNLVK  60
   61 RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ PQVNPKMRFL IFDFIMYCHT 120
  121 RLNLSTSTLF LTFTILDKYS SRFIIKSYNY QLLSLTALWI SSKFWDSKNR MATLKVLQNL 180
  181 CCNQYSIKQF TTMEMHLFKS LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI 240
  241 QQKLALLNNA AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG 300
  301 AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN SFPSSFKSKY 360
  361 LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT IFAQSFDSDS LTCVYSNATT 420
  421 PKSATVSSAA TDYFSDHTHL RRLTKDSISP PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD 480
  481 SASHHSHSGS FSSTQNSFKR SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL 540
  541 FPVRPMATAH PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CDC28 CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3
View Details	Qiu et al. (2008)		CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC28	CLN3	2	Unpublished Fields Lab Data
View Screen	CLN3	CDC28	2	Unpublished Fields Lab Data
View Screen	CLN3	FMP10	2	Unpublished Fields Lab Data
View Screen	CLN3	IMD2	2	Unpublished Fields Lab Data
View Screen	CLN3	NMD5	2	Unpublished Fields Lab Data
View Screen	CLN3	SPA2	2	Unpublished Fields Lab Data
View Screen	CLN3	WHI5	2	Unpublished Fields Lab Data
View Screen	CLN3	PAC1	2	Unpublished Fields Lab Data
View Screen	CLN3	TYE7	2	Unpublished Fields Lab Data
View Screen	CLN3	YPL014W	2	Unpublished Fields Lab Data
View Screen	CLN3	MSY1	2	Unpublished Fields Lab Data
View Screen	CDC28	CLN3	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..83] [210..351]	PSI-BLAST	77.39794	Cyclin A
2	View Details	[84..209]	PSI-BLAST	77.39794	Cyclin A
3	View Details	[352..580]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2