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Protein Overview: CLN3

General Information:
Name(s) found: CLN3 / YAL040C [SGD]
Description(s) found:
Found 28 descriptions.
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  • G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 580 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: vacuole organization [IMPLink to PubMed article]
    G1/S transition of mitotic cell cycle [TASLink to PubMed article]
    regulation of cell size [IMPLink to PubMed article]
    vacuole fusion, non-autophagic [IDALink to PubMed article][IMPLink to PubMed article]
    regulation of cyclin-dependent protein kinase activity [TAS]
    Molecular Function: cyclin-dependent protein kinase regulator activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS AKSKNPNLVK  60
   61 RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ PQVNPKMRFL IFDFIMYCHT 120
  121 RLNLSTSTLF LTFTILDKYS SRFIIKSYNY QLLSLTALWI SSKFWDSKNR MATLKVLQNL 180
  181 CCNQYSIKQF TTMEMHLFKS LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI 240
  241 QQKLALLNNA AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG 300
  301 AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN SFPSSFKSKY 360
  361 LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT IFAQSFDSDS LTCVYSNATT 420
  421 PKSATVSSAA TDYFSDHTHL RRLTKDSISP PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD 480
  481 SASHHSHSGS FSSTQNSFKR SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL 540
  541 FPVRPMATAH PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC28 CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3
    View Details Qiu et al. (2008) CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CLN3 FMP10 2 Unpublished Fields Lab Data
    View Screen CLN3 IMD2 2 Unpublished Fields Lab Data
    View Screen CLN3 NMD5 2 Unpublished Fields Lab Data
    View Screen CLN3 SPA2 2 Unpublished Fields Lab Data
    View Screen CLN3 WHI5 2 Unpublished Fields Lab Data
    View Screen CLN3 PAC1 2 Unpublished Fields Lab Data
    View Screen CLN3 TYE7 2 Unpublished Fields Lab Data
    View Screen CLN3 YPL014W 2 Unpublished Fields Lab Data
    View Screen CLN3 MSY1 2 Unpublished Fields Lab Data
    View Screen CDC28 CLN3 2 Unpublished Fields Lab Data
    View Screen CDC28 CLN3 2 Unpublished Fields Lab Data
    View Screen CLN3 CDC28 2 Unpublished Fields Lab Data
    View Screen LOS1 CLN3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83]
    [210..351]    		 PSI-BLAST 77.39794 Cyclin A
    2 View Details [84..209] PSI-BLAST 77.39794 Cyclin A
    3 View Details [352..580] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle