YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CLB4

General Information:
Name(s) found: CLB4 / YLR210W [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 460 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: G2/M transition of mitotic cell cycle [IGILink to PubMed article][IMPLink to PubMed article]
    S phase of mitotic cell cycle [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of cyclin-dependent protein kinase activity [TAS]
    Molecular Function: cyclin-dependent protein kinase regulator activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLEGYTVQP PQSTLIGDIE IQDENANQEV KNVLYQGVQK GIKRLEKRQR RVALGDVTSQ  60
   61 KANKIHNAIH NKFHQTKNNF EIENIRSSAL VKEQQRDVRH EDSDYFLIDS SEGSSTDDEQ 120
  121 VNEDAIDDLL SRRVNDQQIQ ADEVYEDFDG EMQDVIEEDV DSQIEPLSPI NNDEIQTELD 180
  181 RAFEKYFRSV PNPLDDDTHD VVMVVEYASD IFYYLRELEV KYRPNPYYMQ NQVELTWPFR 240
  241 RTMIDWLVQL HFRFQLLPET LYLTINIVDR FLSKKTVTLN RFQLVGVSAL FIAAKFEEIN 300
  301 CPTLDDLVYM LENTYTRDDI IRAEQYMIDT LEFEIGWPGP MPFLRRISKA DDYDFEPRTL 360
  361 AKYLLETTIV EPKLVAAAPS WLAAGAYFLS RTILGSNDWS LKHVFYSGYT SSQIIPLASL 420
  421 ILENCKNASR RHHSIWKKYF DQKHYRCSQI VEEWIVSTEA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC28 CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3
    View Details Krogan NJ, et al. (2006) ATE1 CDC28 CKS1 CLB2 CLB3 CLB4 CLB5 SIC1 SKG3
    View Details Qiu et al. (2008) CLB1 CLB2 CLB3 CLB4 CLB5 CLB6 CLN1 CLN2 CLN3 MOB1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CLB4 and SPC42 Huh WK, et al. (2003)
    View Data CLB4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] MSA 4.299991 View MSA. No confident structure predictions are available.
    2 View Details [202..217]
    [340..460]    		 PSI-BLAST 396.626727 Cyclin A
    3 View Details [218..339] PSI-BLAST 396.626727 Cyclin A


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle