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Protein Overview: AI1

General Information:
Name(s) found: AI1 / Q0050 [SGD]
Description(s) found:
Found 23 descriptions.
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  • Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 834 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [TASLink to PubMed article]
    Biological Process: cellular respiration [IMPLink to PubMed article]
    mRNA processing [IDALink to PubMed article]
    homing of group II introns [IDALink to PubMed article]
    Molecular Function: nucleic acid binding [TASLink to PubMed article]
    endonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNGAPT  60
   61 SAYISLMRTA LVLWIINRYL KHMTNSVGAN FTGTMACHKT PMISVGGVKC YMVRLTNFLQ 120
  121 VFIRITISSY HLDMVKQVWL FYVEVIRLWF IVLDSTGSVK KMKDTNNTKG NTKSEGSTER 180
  181 GNSGVDRGMV VPNTQMKMRF LNQVRYYSVN NNLKMGKDTN IELSKDTSTS DLLEFEKLVM 240
  241 DNMNEENMNN NLLSIMKNVD MLMLAYNRIK SKPGNMTPGT TLETLDGMNM MYLNKLSNEL 300
  301 GTGKFKFKPM RMVNIPKPKG GMRPLSVGNP RDKIVQEVMR MILDTIFDKK MSTHSHGFRK 360
  361 NMSCQTAIWE VRNMFGGSNW FIEVDLKKCF DTISHDLIIK ELKRYISDKG FIDLVYKLLR 420
  421 AGYIDEKGTY HKPMLGLPQG SLISPILCNI VMTLVDNWLE DYINLYNKGK VKKQHPTYKK 480
  481 LSRMIAKAKM FSTRLKLHKE RAKGPTFIYN DPNFKRMKYV RYADDILIGV LGSKNDCKMI 540
  541 KRDLNNFLNS LGLTMNEEKT LITCATETPA RFLGYNISIT PLKRMPTVTK TIRGKTIRSR 600
  601 NTTRPIINAP IRDIINKLAT NGYCKHNKNG RMGVPTRVGR WTYEEPRTII NNYKALGRGI 660
  661 LNYYKLATNY KRLRERIYYV LYYSCVLTLA SKYRLKTMSK TIKKFGYNLN IIENDKLIAN 720
  721 FPRNTFDNIK KIENHGMFMY MSEAKVTDPF EYIDSIKYML PTAKANFNKP CSICNSTIDV 780
  781 EMHHVKQLHR GMLKATKDYI TGRMITMNRK QIPLCKQCHI KTHKNKFKNM GPGM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AI1 LTE1 TAZ1
    View Details Ho Y, et al. (2002) AI1 FUN12 HHO1 IMD2 IMD3 IMD4 MAG1 MPH1 MSH2 NOP12 RET1 RPC82 TIF4631 TIF4632 UTP22
    View Details Qiu et al. (2008) AI1 AI2 AI4 AI5_ALPHA SCEI

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] PSI-BLAST 42.522879 Mitochondrial cytochrome c oxidase, subunit I
    2 View Details [93..666] FFAS03 2.1 No description for 2ijd1 was found.
    3 View Details [667..834] Pfam 17.309804 No description for PF01348.12 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA polymerase activity
    		•  3.48899522091554 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  3.47530593895491 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.44935357223617 bayes_pls_golite062009
  • DNA binding
    		•  1.04980164056055 bayes_pls_golite062009
  • catalytic activity
    		•  0.985794797454925 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.977829931092877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.916757424850137 bayes_pls_golite062009
  • binding
    		•  0.826541132106647 bayes_pls_golite062009
  • transferase activity
    		•  0.562916058192021 bayes_pls_golite062009
  • exonuclease activity
    		•  0.478231141372817 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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