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Protein Overview: AI2

General Information:
Name(s) found: AI2 / Q0055 [SGD]
Description(s) found:
Found 23 descriptions.
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  • Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 854 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [TASLink to PubMed article]
    Biological Process: RNA splicing [TASLink to PubMed article]
    Molecular Function: nucleic acid binding [TASLink to PubMed article]
    RNA-directed DNA polymerase activity [TASLink to PubMed article]
    RNA binding [TASLink to PubMed article]
    endonuclease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVV  60
   61 GHAVLMIFCA PFRLIYHCIE VLIDKHISVY SINENFTVSF WFWLLVVTYM VFRYVNHMAY 120
  121 PVGANSTGTM ACHKSAGVKQ PAQGKNCPMA RLTNSCKECL GFSLTPSHLG IVIHAYVLEE 180
  181 EVHELTKNES LALSKSWHLE GCTSSNGKLR NTGLSERGNP GDNGVFMVPK FNLNKVRYFS 240
  241 TLSKLNARKE DSLAYLTKIN TTDFSELNKL MENNHNKTET INTRILKLMS DIRMLLIAYN 300
  301 KIKSKKGNMS KGSNNITLDG INISYLNKLS KDINTNMFKF SPVRRVEIPK TSGGFRPLSV 360
  361 GNPREKIVQE SMRMMLEIIY NNSFSYYSHG FRPNLSCLTA IIQCKNYMQY CNWFIKVDLN 420
  421 KCFDTIPHNM LINVLNERIK DKGFMDLLYK LLRAGYVDKN NNYHNTTLGI PQGSVVSPIL 480
  481 CNIFLDKLDK YLENKFENEF NTGNMSNRGR NPIYNSLSSK IYRCKLLSEK LKLIRLRDHY 540
  541 QRNMGSDKSF KRAYFVRYAD DIIIGVMGSH NDCKNILNDI NNFLKENLGM SINMDKSVIK 600
  601 HSKEGVSFLG YDVKVTPWEK RPYRMIKKGD NFIRVRHHTS LVVNAPIRSI VMKLNKHGYC 660
  661 SHGILGKPRG VGRLIHEEMK TILMHYLAVG RGIMNYYRLA TNFTTLRGRI TYILFYSCCL 720
  721 TLARKFKLNT VKKVILKFGK VLVDPHSKVS FSIDDFKIRH KMNMTDSNYT PDEILDRYKY 780
  781 MLPRSLSLFS GICQICGSKH DLEVHHVRTL NNAANKIKDD YLLGRMIKMN RKQITICKTC 840
  841 HFKVHQGKYN GPGL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AI1 AI2 AI4 BI2 BI3 BI4 SEN15

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..259] PSI-BLAST 89.522879 Mitochondrial cytochrome c oxidase, subunit I
    2 View Details [260..707] FFAS03 2.24 Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16
    3 View Details [708..854] Pfam 10.638272 No description for PF01348.12 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • heme-copper terminal oxidase activity
    		•  5.45481380399883 bayes_pls_golite062009
  • cytochrome-c oxidase activity
    		•  5.0434003897137 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors
    		•  5.0434003897137 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
    		•  5.0434003897137 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.67498134749296 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.49704329043685 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.31093171497983 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.74570258984477 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  2.92202780814066 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.43526852804891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.24124755133579 bayes_pls_golite062009
  • catalytic activity
    		•  1.95966890211023 bayes_pls_golite062009
  • binding
    		•  0.733970829597091 bayes_pls_golite062009
    2
    Term Confidence Notes
  • DNA polymerase activity
    		•  3.48899522091554 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  3.47530593895491 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.44935357223617 bayes_pls_golite062009
  • DNA binding
    		•  1.04980164056055 bayes_pls_golite062009
  • catalytic activity
    		•  0.985794797454925 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.977829931092877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.916757424850137 bayes_pls_golite062009
  • binding
    		•  0.826541132106647 bayes_pls_golite062009
  • transferase activity
    		•  0.562916058192021 bayes_pls_golite062009
  • exonuclease activity
    		•  0.478231141372817 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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