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Protein Overview: DUN1_YEAST

General Information:
Name(s) found: DUN1_YEAST [Swiss-Prot]
Description(s) found:
  • DNA damage response protein kinase DUN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUN1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 513 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSTKREHS GDVTDSSFKR QQRSNKPSSE YTCLGHLVNL IPGKEQKVEI TNRNVTTIGR  60
   61 SRSCDVILSE PDISTFHAEF HLLQMDVDNF QRNLINVIDK SRNGTFINGN RLVKKDYILK 120
  121 NGDRIVFGKS CSFLFKYASS SSTDIENDDE KVSSESRSYK NDDEVFKKPQ ISATSSQNAT 180
  181 TSAAIRKLNK TRPVSFFDKY LLGKELGAGH YALVKEAKNK KTGQQVAVKI FHAQQNDDQK 240
  241 KNKQFREETN ILMRVQHPNI VNLLDSFVEP ISKSQIQKYL VLEKIDDGEL FERIVRKTCL 300
  301 RQDESKALFK QLLTGLKYLH EQNIIHRDIK PENILLNITR RENPSQVQLG PWDEDEIDIQ 360
  361 VKIADFGLAK FTGEMQFTNT LCGTPSYVAP EVLTKKGYTS KVDLWSAGVI LYVCLCGFPP 420
  421 FSDQLGPPSL KEQILQAKYA FYSPYWDKID DSVLHLISNL LVLNPDERYN IDEALNHPWF 480
  481 NDIQQQSSVS LELQRLQITD NKIPKTYSEL SCL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] PSI-BLAST 22.39794 Chk2 kinase
    2 View Details [153..287]
    [501..513]    		 PSI-BLAST 636.457575 Calmodulin-dependent protein kinase
    3 View Details [288..500] PSI-BLAST 636.457575 Calmodulin-dependent protein kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.23926962992034 bayes_pls_golite062009
  • DNA binding
    		•  3.12131448113144 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.91028042727128 bayes_pls_golite062009
  • histone binding
    		•  2.79033314021304 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.78221661189523 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.56188495627199 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.25132862320271 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  2.06369312345519 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.95921851331594 bayes_pls_golite062009
  • transcription factor activity
    		•  1.89464382469326 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.84746485315093 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.78280248668052 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.78246425241581 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • SMAD binding
    		•  1.58868248655216 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.58437603150322 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5642245057124 bayes_pls_golite062009
  • transcription activator activity
    		•  1.53960544319629 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.48483625404671 bayes_pls_golite062009
  • promoter binding
    		•  1.34105825186678 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • transcription factor binding
    		•  0.93544177518754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.9108432673413 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.90981150861416 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • signal transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • R-SMAD binding
    		•  0.70816286022176 bayes_pls_golite062009
  • chromatin binding
    		•  0.62935034847038 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.459063012088486 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.459063012088486 bayes_pls_golite062009
  • enzyme binding
    		•  0.34998623523914 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • co-SMAD binding
    		•  0.325865547214071 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.279328480488455 bayes_pls_golite062009
  • collagen binding
    		•  0.241950844569571 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.121846363304069 bayes_pls_golite062009
  • receptor binding
    		•  0.0581553668794451 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • actin binding
    		•  2.37384162366989 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • telethonin binding
    		•  2.27062712605521 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • alpha-actinin binding
    		•  1.38861866085902 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30988141770642 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • actin filament binding
    		•  1.20555646820348 bayes_pls_golite062009
  • DNA binding
    		•  1.17130513163489 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.959888295228949 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • transcription factor activity
    		•  0.919430701010326 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.51726292539973 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.343240719858581 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle