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Protein Overview: PDPK1_ARATH

General Information:
Name(s) found: PDPK1_ARATH [Swiss-Prot]
Description(s) found:
Found 12 descriptions.
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  • 3-phosphoinositide-dependent protein kinase 1 OS=Arabidopsis thaliana GN=PDPK1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: positive regulation of protein kinase activity [IDA]
    Molecular Function: protein binding [IPI]
    phosphoinositide binding [IDA]
    protein kinase activity [IDA]
    kinase activity [ISS]
    3-phosphoinositide-dependent protein kinase activity [IGI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAMEKEFDS KLVLQGNSSN GANVSRSKSF SFKAPQENFT SHDFEFGKIY GVGSYSKVVR  60
   61 AKKKETGTVY ALKIMDKKFI TKENKTAYVK LERIVLDQLE HPGIIKLYFT FQDTSSLYMA 120
  121 LESCEGGELF DQITRKGRLS EDEARFYTAE VVDALEYIHS MGLIHRDIKP ENLLLTSDGH 180
  181 IKIADFGSVK PMQDSQITVL PNAASDDKAC TFVGTAAYVP PEVLNSSPAT FGNDLWALGC 240
  241 TLYQMLSGTS PFKDASEWLI FQRIIARDIK FPNHFSEAAR DLIDRLLDTE PSRRPGAGSE 300
  301 GYVALKRHPF FNGVDWKNLR SQTPPKLAPD PASQTASPER DDTHGSPWNL THIGDSLATQ 360
  361 NEGHSAPPTS SESSGSITRL ASIDSFDSRW QQFLEPGESV LMISAVKKLQ KITSKKVQLI 420
  421 LTNKPKLIYV DPSKLVVKGN IIWSDNSNDL NVVVTSPSHF KICTPKKVLS FEDAKQRASV 480
  481 WKKAIETLQN R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..360] PSI-BLAST 69.522879 Structure of human PDK1 kinase domain in complex with staurosporine
    2 View Details [361..491] PSI-BLAST 28.0 Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.25285260301349 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.1208666000428 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • actin binding
    		•  1.00749371062134 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655396214040669 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.631882811427766 bayes_pls_golite062009
  • DNA binding
    		•  0.599969415455862 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • tubulin binding
    		•  0.488928950975855 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transcription factor activity
    		•  0.457173041568166 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • receptor binding
    		•  0.197402253061255 bayes_pls_golite062009
  • microtubule binding
    		•  0.196718452862042 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • collagen binding
    		•  0.126438719981406 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • actin binding
    		•  2.85686087329077 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.48216092627697 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.53043443218632 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.51333207678681 bayes_pls_golite062009
  • kinase activity
    		•  1.49733072352288 bayes_pls_golite062009
  • SH2 domain binding
    		•  1.41526564231882 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.3855488465667 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36365892826676 bayes_pls_golite062009
  • protein kinase activity
    		•  1.34246406302496 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.30262007369665 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • receptor binding
    		•  1.28569939553368 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  1.19081327922916 bayes_pls_golite062009
  • actin filament binding
    		•  1.19004539998398 bayes_pls_golite062009
  • receptor activity
    		•  1.1755016270537 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.17024030272587 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.1152029796159 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • transferase activity
    		•  1.05502123133116 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.04786326338998 bayes_pls_golite062009
  • DNA binding
    		•  1.02624078384285 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.00400540041137 bayes_pls_golite062009
  • kinase binding
    		•  0.961706066143 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • protein kinase binding
    		•  0.67284191028382 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.611829373978789 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • structural molecule activity
    		•  0.320527491838187 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.28468123649303 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.261970566755445 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • lipid binding
    		•  0.179561240451969 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle