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View Structure Prediction Details

Protein: C71AF_ARATH
Organism: Arabidopsis thaliana
Length: 496 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C71AF_ARATH.

Description E-value Query
Range		 Subject
Range
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
 416.0 [0..1] [494..1]

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Predicted Domain #1
Region A:
Residues: [1-496] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIIIISLCL ATILAFLLLK PLLNRTVAKD NLPPSPWRVP VIGNLHQLSL HPHRSLRSLS  60
   61 HRYGPLMLLH FGRVPILVVS SSDVAHDLMK THDLKVANRP RLKVIETILN GGREVVFSPY 120
  121 GDYWRQIKTV CVVHLLNKKM VQSFAKVREE ERSVMMEKVE KASSDSSPLN LSKLLITLTS 180
  181 DVASRVSFGK KHSNEASMSD FKNQVRKITE LVGGFPVSEY IPCLAWIDQI RGLYNRAEEV 240
  241 SKIFGDLMDK VVQEHLDATN KPTKDFVDIL LSFERQSKDG IEVRRSDIKF IILDIFLGGT 300
  301 TTTNSLLEWT MTELIRHPEC MKKLQDEIRG DATNLTIYRS HEEVEDMKYL KAVIKEGLRL 360
  361 HPPFPLLVLR LLTQDVKLKG YDIAAGTQVI TNAWAIQRDI VTWGIDAEEF RPERHLDSPL 420
  421 DFRGTNFEYI PFGSGRRICP GIGFAMALVE VTLANLVNRF NWRMDARLSG DEYDLAEATG 480
  481 IDVCRKFPLI VFPSNA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.0
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
electron carrier activity 4.64931978461551 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxygen binding 3.29945075872446 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 3.16634614522939 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
protein binding 0.836411857417911 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 0.7601272997427 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.658520486133281 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
iron ion binding 0.529598228513719 bayes_pls_golite062009
cation binding 0.510556740388808 bayes_pls_golite062009
metal ion binding 0.510556740388808 bayes_pls_golite062009
ion binding 0.503326724714616 bayes_pls_golite062009
transition metal ion binding 0.450436868179747 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009
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