| Protein: | daf-4 |
| Organism: | Caenorhabditis elegans |
| Length: | 592 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
|
Region A: Residues: [1-105] |
1 11 21 31 41 51
| | | | | |
1 MPYQHADSMN CENESSCRQG RSFRGGIGMC CCSTNNCNMP DLIEMVNPSL KKDSDNSALL 60
61 WASTPSNMDL ESLDKFPFYW IIIIALSVIL CIALLILAYV GWKFQ
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [106-451] |
1 11 21 31 41 51
| | | | | |
1 QNKKEEIKKQ QKIKFDMEKT DALEAGNVPL VEPEEEMIEM VETPKELPIT DFQLISKGRF 60
61 GKVFKAQYTP DSGEKRLVAV KKLNEFQKAS FLAEKRIFDE LNEYPKWYKS IVEFVCAEKI 120
121 GDEYWIVTEF HERLSLYELL KNNVISITSA NRIIMSMIDG LQFLHDDRPY FFGHPKKPII 180
181 HRDIKSKNIL VKSDMTTCIA DFGLARIYSY DIEQSDLLGQ VGTKRYMSPE MLEGATEFTP 240
241 TAFKAMDVYS MGLVMWEVIS RTKLHQTDEP PNYQMPFQVI GFDPTIGLMR NYVVSKKERP 300
301 QWRDEIIKHE YMSLLKKVTE EMWDPEACAR ITAGCAFARV WNHIMS
|
| Detection Method: | |
| Confidence: | 56.39794 |
| Match: | 1b6cB |
| Description: | Type I TGF-beta receptor R4 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| activin receptor activity | 7.18922615745589 | bayes_pls_golite062009 |
| activin binding | 7.11944534332244 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 6.41728494915949 | bayes_pls_golite062009 |
| activin receptor activity, type I | 6.1393596497059 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 3.37600307408153 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 3.37600307408153 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 2.97315540587667 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 2.57601476622612 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| insulin receptor activity | 2.08642574110801 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 2.00819948109978 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.90879495821405 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.82118598657067 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 1.46877913443522 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.28428643482914 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| structural molecule activity | 1.10436308210353 | bayes_pls_golite062009 |
| insulin binding | 1.03564126441771 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| transcription repressor activity | 0.959888295228949 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| amine binding | 0.783881819862438 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.748533008006377 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.57617745233877 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| follistatin binding | 0.407208295811976 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.399773397398032 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| PTB domain binding | 0.384625387464921 | bayes_pls_golite062009 |
| insulin receptor binding | 0.379040209226037 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type II | 0.365530951355731 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.34434685718027 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| glycoprotein binding | 0.2984932537448 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.294256794094724 | bayes_pls_golite062009 |
| kinase binding | 0.26752427107238 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| polysaccharide binding | 0.229808864843639 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 0.150740450460731 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| protein kinase C activity | 0.0795689006739899 | bayes_pls_golite062009 |
| tubulin binding | 0.0510156114567444 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.0123645889643007 | bayes_pls_golite062009 |
| protein kinase binding | 0.00674998152095019 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
| SH2 domain binding | 2.96656737540424E-4 | bayes_pls_golite062009 |
|
Region A: Residues: [452-592] |
1 11 21 31 41 51
| | | | | |
1 SPDSSEGYHS GSSMKNRGVD DVEQSEKPEG IEEMQHYHAS SPSKRQHPSP NPFFDSCPPP 60
61 PPIPVILENG GILQPDNAEP EPEELPDLPI VEKIYDIATN MLFSREELDL MNAQRQVEYE 120
121 AGADTRASTP TPSGTFGTFT T
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
