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View Structure Prediction Details

Protein: cyp-32B1
Organism: Caenorhabditis elegans
Length: 516 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyp-32B1.

Description E-value Query
Range
Subject
Range
gi|76654204 - gi|76654204|ref|XP_584699.2| PREDICTED: similar to cytochrome P450, subfamily IIIA, polypeptide 4 is...
393.0 [0..6] [513..3]

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Predicted Domain #1
Region A:
Residues: [1-516]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAAALVLLL TYFAYLIFRQ KDDILQFLHV RKICTREFKK LRGPPAVLIF GTLWYFKKDP  60
   61 VEMVYQAQAW FSEYTLAPDN CGVLKLWLGP IPAVNIARGE IAKIVLDSSV NISKSSQYNK 120
  121 LKEWIGDGLL ISTGDKWRSR RKMLTQTFHF AVLKEYQKIF GAQGKILVEV LQLRANNKFS 180
  181 FDIMPYIKRC ALDIICETAM GCSISSQRGA NDEYVNSVRR LSEIVWNYEK APQFWLKPIW 240
  241 YLFGDGFEFN RHVKLTTDFT RDVIENRKKE LKTHNSEQNE TKKLAFLDYL LKSQEEHPDI 300
  301 LTDEGIREEV DTFMFEGHDT TSSGITFAVW FLGQFPEYQQ RVHDELDEIF GEDFERIPNS 360
  361 EDIQKMVYLE QCIKETLRMT PPVPFVSRKL TEDVKIPHAT KPDLLLPAGI NCMINIITIM 420
  421 KDARYFERPY EFFPEHFSPE RVAAREPFAF VPFSAGPRNC IGQKFALLEE KVLLSWIFRN 480
  481 FTVTSMTKFP EEMPIPELIL KPQFGTQVLL RNRRKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 102.0
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
oxygen binding 3.29945075872446 bayes_pls_golite062009
fluorene oxygenase activity 3.16634614522939 bayes_pls_golite062009
demethylase activity 2.80780658333504 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
sterol 14-demethylase activity 2.33937429425924 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.27465774301343 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 2.0071742914584 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 1.71233606135238 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
retinoid binding 1.55427837836259 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
isoprenoid binding 1.43053384013166 bayes_pls_golite062009
retinoic acid binding 1.21667685596765 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 0.38659560844654 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors 0.0784478774178976 bayes_pls_golite062009
transition metal ion binding 0.0236268519265949 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle