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View Structure Prediction Details

Protein: cyp-25A5
Organism: Caenorhabditis elegans
Length: 477 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyp-25A5.

Description E-value Query
Range		 Subject
Range
gi|115496944, gi... - gi|94574282|gb|AAI16042.1| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi|1...
 362.0 [0..34] [475..28]

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Predicted Domain #1
Region A:
Residues: [1-477] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAILIISTIF FTIITFISYI IWRRHSIFKL RSSIGIPGPP GYCKVMKFYS KNNFSLYCGT  60
   61 QLHITVSEEE DIKEIFIQNF SNFSDRMTPN IFGMNQLNQS LLQNTYATGW KHTRSAVAPI 120
  121 FSTGKMKAMH ETLVSKIDIF LEVLKEKSSS GQKWDIFDNF QSLSLDIIGK CAFAIDSNCQ 180
  181 RDRIDLFYVQ ARKFVGAVAL KKSWILPVSL ILPELSWLWR FLYKFSDLSA AELPLVKGLV 240
  241 DLYDRRRAGE GGNDSTDLLN LLIRRETIGK MTKREVIENC FAFLIAGYET TSTAMMFSAY 300
  301 LLAEYPIVQQ KLYEEIKKTK ESAGLNYDSI HNMKYSDCVY KESLRFYPPT THFTNRVCLN 360
  361 DMTIQGQIYP KDSTLKVQPH TIHRNPANWE SPDEFQPERF ENWEEKSSSL KWIPFGVGPR 420
  421 YCVGMRFAEM EFKTTIAKLL DTFELSLVPG DPPMIPETNG VIFRPRCPVR LNLKLRI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.522879
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
oxygen binding 3.29945075872446 bayes_pls_golite062009
demethylase activity 2.80780658333504 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
sterol 14-demethylase activity 2.33937429425924 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 2.24146036195166 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.21042366294727 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
retinoic acid binding 1.55035199545719 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 1.48500938886158 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.4105861338158 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.4105861338158 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 0.89030345144459 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.203772707673481 bayes_pls_golite062009
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