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View Structure Prediction Details

Protein: Cyp12a4-PA
Organism: Drosophila melanogaster
Length: 536 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Cyp12a4-PA.

Description E-value Query
Range		 Subject
Range
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
 362.0 [0..19] [534..3]

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Predicted Domain #1
Region A:
Residues: [1-536] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKVRSALSL IQSQKATLSL ATQKRWQTNV ATAEAREDSE WLQAKPFEQI PRLNMWALSM  60
   61 KMSMPGGKYK NMELMEMFEA MRQDYGDIFF MPGIMGNPPF LSTHNPQDFE VVFRNEGVWP 120
  121 NRPGNYTLLY HREEYRKDFY QGVMGVIPTQ GKPWGDFRTV VNPVLMQPKN VRLYYKKMSQ 180
  181 VNQEFVQRIL ELRDPDTLEA PDDFIDTINR WTLESVSVVA LDKQLGLLKN SNKESEALKL 240
  241 FHYLDEFFIV SIDLEMKPSP WRYIKTPKLK RLMRALDGIQ EVTLAYVDEA IERLDKEAKE 300
  301 GVVRPENEQS VLEKLLKVDR KVATVMAMDM LMAGVDTTSS TFTALLLCLA KNPEKQARLR 360
  361 EEVMKVLPNK NSEFTEASMK NVPYLRACIK ESQRLHPLIV GNARVLARDA VLSGYRVPAG 420
  421 TYVNIVPLNA LTRDEYFPQA SEFLPERWLR SPKDSESKCP ANELKSTNPF VFLPFGFGPR 480
  481 MCVGKRIVEM ELELGTARLI RNFNVEFNYP TENAFRSALI NLPNIPLKFK FIDLPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.39794
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.79253506790596 bayes_pls_golite062009
oxygen binding 3.7203678182299 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 2.69642243567771 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 2.69642243567771 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
arachidonic acid monooxygenase activity 2.35162461983176 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 2.30416050662077 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors 1.70263392462058 bayes_pls_golite062009
retinoic acid binding 1.69236715381231 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 1.58167166311061 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 1.42927429551354 bayes_pls_golite062009
transition metal ion binding 1.39485992496073 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.20113920678403 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
iron ion binding 1.05714805569149 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 0.979631262400031 bayes_pls_golite062009
cation binding 0.934330913850428 bayes_pls_golite062009
metal ion binding 0.934330913850428 bayes_pls_golite062009
ion binding 0.927080243591876 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 0.89030345144459 bayes_pls_golite062009
protein binding 0.836411857417911 bayes_pls_golite062009
arachidonic acid epoxygenase activity 0.75181432044872 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 0.201977555505571 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle