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View Structure Prediction Details

Protein: gi|20140914, gi|...
Organism: Homo sapiens
Length: 593 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|20140914, gi|....

Description E-value Query
Range
Subject
Range
gi|113426698 - gi|113426698|ref|XP_042698.4| PREDICTED: similar to Ubiquitin carboxyl-terminal hydrolase 22 (Ubiqui...
0.0 [8..593] [215..800]
gi|76644257 - gi|76644257|ref|XP_586712.2| PREDICTED: similar to Ubiquitin carboxyl-terminal hydrolase 22 (Ubiquit...
0.0 [2..593] [74..676]
UBP22_MOUSE - Ubiquitin carboxyl-terminal hydrolase 22 OS=Mus musculus GN=Usp22 PE=2 SV=2
0.0 [70..593] [2..525]
gi|50418363, gi|... - gi|50418363|gb|AAH78033.1| Usp27x protein [Xenopus laevis], gi|147904969|ref|NP_001090240.1| X-linke...
0.0 [84..593] [48..572]
gi|109510503 - gi|109510503|ref|XP_228777.4| PREDICTED: similar to ubiquitin specific protease 27, X chromosome [Ra...
0.0 [80..593] [200..728]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAAARGRCLP CSLPSAIAQP HLCPASALCS RRPGLGQPGQ PPSSPHAALA SSSPPSPPPP  60
   61 ARGRALPPMV SRPEPEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [78-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAMDAELAVA PPGCSHLGSF KVDNWKQNLR AIYQCFVWSG TAEARKRKAK SCICHVCGVH  60
   61 LNRLHSCLYC VFFGCFTKKH IHEHAKAKRH NLAIDLMYGG IYCFLCQDYI YDKDMEIIAK 120
  121 EEQRKAWKMQ GVGEKFSTWE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 2g43A
Description: No description for 2g43A was found.

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.97121728620188 bayes_pls_golite062009
small conjugating protein ligase activity 5.78935175140238 bayes_pls_golite062009
acid-amino acid ligase activity 4.75377804653841 bayes_pls_golite062009
small conjugating protein-specific protease activity 3.4560986989594 bayes_pls_golite062009
ubiquitin-specific protease activity 3.40436079043913 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
cysteine-type peptidase activity 2.7771990270637 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.57382484274962 bayes_pls_golite062009
ligase activity 2.30828657077565 bayes_pls_golite062009
ubiquitin thiolesterase activity 2.27286633653932 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.11206038007886 bayes_pls_golite062009
nucleic acid binding 2.01888784395048 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription activator activity 1.45530270292081 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
thiolester hydrolase activity 1.04342463991885 bayes_pls_golite062009
sequence-specific DNA binding 0.926364718530146 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
hydrolase activity 0.52386813728704 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
transcription coactivator activity 0.255669498391574 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [218-593]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTKRELELLK HNPKRRKITS NCTIGLRGLI NLGNTCFMNC IVQALTHTPL LRDFFLSDRH  60
   61 RCEMQSPSSC LVCEMSSLFQ EFYSGHRSPH IPYKLLHLVW THARHLAGYE QQDAHEFLIA 120
  121 ALDVLHRHCK GDDNGKKANN PNHCNCIIDQ IFTGGLQSDV TCQVCHGVST TIDPFWDISL 180
  181 DLPGSSTPFW PLSPGSEGNV VNGESHVSGT TTLTDCLRRF TRPEHLGSSA KIKCSGCHSY 240
  241 QESTKQLTMK KLPIVACFHL KRFEHSAKLR RKITTYVSFP LELDMTPFMA SSKESRMNGQ 300
  301 YQQPTDSLNN DNKYSLFAVV NHQGTLESGH YTSFIRQHKD QWFKCDDAII TKASIKDVLD 360
  361 SEGYLLFYHK QFLEYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.045757
Match: 2ibiA
Description: No description for 2ibiA was found.

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
N-acetyltransferase activity 5.98024578817189 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.72435045666828 bayes_pls_golite062009
histone acetyltransferase activity 5.72435045666828 bayes_pls_golite062009
N-acyltransferase activity 5.54975627252977 bayes_pls_golite062009
acetyltransferase activity 4.98167814132869 bayes_pls_golite062009
transferase activity, transferring acyl groups 4.63274143638005 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
acyltransferase activity 4.01951010659818 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.96057134514922 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
peptidase activity 2.8192612691912 bayes_pls_golite062009
hydrolase activity 2.66167923792227 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
endopeptidase activity 2.56654871607946 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.55227247835105 bayes_pls_golite062009
transcription regulator activity 2.13534310479552 bayes_pls_golite062009
cytoskeletal protein binding 2.13397229861051 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
DNA binding 1.95013248594294 bayes_pls_golite062009
protein binding 1.92445772322782 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
tubulin binding 1.85112496470487 bayes_pls_golite062009
microtubule binding 1.82320858139311 bayes_pls_golite062009
nucleic acid binding 1.74961503597682 bayes_pls_golite062009
transcription activator activity 1.24058404587058 bayes_pls_golite062009
transcription factor activity 1.20242512567523 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
structural molecule activity 0.297752217869698 bayes_pls_golite062009
signal transducer activity 0.26868506520228 bayes_pls_golite062009
molecular transducer activity 0.26868506520228 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
ligase activity 0.109097233197606 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle