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View Structure Prediction Details

Protein: RPS6KA3
Organism: Homo sapiens
Length: 740 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPS6KA3.

Description E-value Query
Range		 Subject
Range
gi|109511791, gi... - gi|109511791|ref|XP_001054840.1| PREDICTED: similar to ribosomal protein S6 kinase polypeptide 3 [Ra...
 0.0 [1..740] [132..871]
gi|33304069 - gi|33304069|gb|AAQ02542.1| ribosomal protein S6 kinase, 90kDa, polypeptide 3 [synthetic construct]
 0.0 [1..740] [1..740]
tr|M3WDY3|M3WDY3... - Ribosomal protein S6 kinase OS=Felis catus GN=RPS6KA3 PE=3 SV=1
gi|183396847 - gi|183396847|gb|AAI65985.1| Ribosomal protein S6 kinase polypeptide 3 [synthetic construct]
KS6A3_MOUSE - Ribosomal protein S6 kinase alpha-3 OS=Mus musculus GN=Rps6ka3 PE=1 SV=2
gi|154707846, gi... - gi|154707846|ref|NP_001092407.1| ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Bos taurus], gi|...
 0.0 [1..740] [1..740]
gi|64654466 - gi|64654466|gb|AAH96303.1| Ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo sapiens]
 0.0 [1..740] [1..740]
gi|50730201 - gi|50730201|ref|XP_416804.1| PREDICTED: similar to ribosomal protein S6 kinase 2 [Gallus gallus]
 0.0 [2..740] [405..1153]
gi|148228921, gi... - gi|6537166|gb|AAF15553.1|AF165162_1 Rsk-2 [Xenopus laevis], gi|51258315|gb|AAH80017.1| RSK2 protein ...
 0.0 [1..740] [1..737]
gi|74006583 - gi|74006583|ref|XP_548888.2| PREDICTED: similar to ribosomal protein S6 kinase polypeptide 3 isoform...
 0.0 [39..740] [10..711]
gi|68359863 - gi|68359863|ref|XP_689830.1| PREDICTED: similar to Ribosomal protein S6 kinase polypeptide 3 isoform...
 0.0 [1..740] [1..733]

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Predicted Domain #1
Region A:
Residues: [1-340] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI AITHHVKEGH  60
   61 EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD 120
  121 ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA 180
  181 LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240
  241 NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR 300
  301 MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.045757
Match: 1vzoA
Description: The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
tau-protein kinase activity 2.00481226596005 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.55257528159541 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
ErbB-2 class receptor binding 1.02996109010965 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
gamma-tubulin binding 0.242410242748222 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 0.01826424351081 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [341-409] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPPFKPATGR PEDTFYFDPE FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ  60
   61 TVGVHSIVQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.03
Match: 2esmA
Description: Crystal Structure of ROCK 1 bound to fasudil
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [410-740] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLHRNSIQFT DGYEVKEDIG VGSYSVCKRC IHKATNMEFA VKIIDKSKRD PTEEIEILLR  60
   61 YGQHPNIITL KDVYDDGKYV YVVTELMKGG ELLDKILRQK FFSEREASAV LFTITKTVEY 120
  121 LHAQGVVHRD LKPSNILYVD ESGNPESIRI CDFGFAKQLR AENGLLMTPC YTANFVAPEV 180
  181 LKRQGYDAAC DIWSLGVLLY TMLTGYTPFA NGPDDTPEEI LARIGSGKFS LSGGYWNSVS 240
  241 DTAKDLVSKM LHVDPHQRLT AALVLRHPWI VHWDQLPQYQ LNRQDAPHLV KGAMAATYSA 300
  301 LNRNQSPVLE PVGRSTLAQR RGIKKITSTA L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.522879
Match: 1mrvA
Description: crystal structure of an inactive Akt2 kinase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
tau-protein kinase activity 2.00481226596005 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.55257528159541 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
ErbB-2 class receptor binding 1.02996109010965 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
gamma-tubulin binding 0.242410242748222 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 0.01826424351081 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009
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