YRC Public Data Repository - Protein Structure Prediction

Protein:	MOT1
Organism:	Saccharomyces cerevisiae
Length:	1867 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MOT1.

Description	E-value	Query Range	Subject Range
BTAF1 - BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisia...	0.0	[5..1867]	[3..1849]
gi\|85090821 - gi\|85090821\|ref\|XP_958601.1\| hypothetical protein NCU07556 [Neurospora crassa OR74A] gi\|28919976, gi\|... - gi\|32414725\|ref\|XP_327842.1\| hypothetical protein [Neurospora crassa], gi\|28919976\|gb\|EAA29365.1\| hy...	0.0	[6..1867]	[3..1893]
gi\|6822074, gi\|1... - gi\|6822074\|emb\|CAB71002.1\| TATA box binding protein (TBP) associated factor (TAF)-like protein [Arab...	0.0	[243..1866]	[423..2047]
CE15856 - WBGene00000274 locus:btf-1 helicase status:Partially_confirmed TR:O45899 protein_id:CAB04949.1	0.0	[257..1864]	[38..1527]
MOT1_YEAST - TATA-binding protein-associated factor MOT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... MOT1 - Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA vi... gi\|151942715 - gi\|151942715\|gb\|EDN61061.1\| modifier of transcription [Saccharomyces cerevisiae YJM789]	0.0	[1..1867]	[1..1867]
gi\|23171428, gi\|... - gi\|24647318\|ref\|NP_732097.1\| helicase 89B [Drosophila melanogaster], gi\|23171428\|gb\|AAF55260.2\| heli...	0.0	[6..1867]	[9..1928]
gi\|19072776 - gi\|19072776\|gb\|AAL84633.1\|AF474993_1 putative transcription regulator WdMOT1 [Exophiala dermatitidis...	0.0	[14..1094]	[33..1132]
gi\|4495126 - gi\|4495126\|emb\|CAB37625.2\| SPBC1826.01c [Schizosaccharomyces pombe]	0.0	[226..1264]	[1..1048]

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Predicted Domain #1

Region A:
Residues: [1-266]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSRVSRLDR QVILIETGST QVVRNMAADQ MGDLAKQHPE DILSLLSRVY PFLLVKKWET  60
   61 RVTAARAVGG IVAHAPSWDP NESDLVGGTN EGSPLDNAQV KLEHEMKIKL EEATQNNQLN 120
  121 LLQEDHHLSS LSDWKLNEIL KSGKVLLASS MNDYNVLGKA DDNIRKQAKT DDIKQETSML 180
  181 NASDKANENK SNANKKSARM LAMARRKKKM SAKNTPKHPV DITESSVSKT LLNGKNMTNS 240
  241 AASLATSPTS NQLNPKLEIT EQADES

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [267-460]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLMIESTVRP LLEQHEIVAG LVWQFQGIYE LLLDNLMSEN WEIRHGAALG LRELVKKHAY  60
   61 GVSRVKGNTR EENNLRNSRS LEDLASRLLT VFALDRFGDY VYDTVVAPVR ESVAQTLAAL 120
  121 LIHLDSTLSI KIFNCLEQLV LQDPLQTGLP NKIWEATHGG LLGIRYFVSI KTNFLFAHGL 180
  181 LENVVRIVLY GLNQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [461-689]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDDDVQSVAA SILTPITSEF VKLNNSTIEI LVTTIWSLLA RLDDDISSSV GSIMDLLAKL  60
   61 CDHQEVLDIL KNKALEHPSE WSFKSLVPKL YPFLRHSISS VRRAVLNLLI AFLSIKDDST 120
  121 KNWLNGKVFR LVFQNILLEQ NPELLQLSFD VYVALLEHYK VKHTEKTLDH VFSKHLQPIL 180
  181 HLLNTPVGEK GKNYAMESQY ILKPSQHYQL HPEKKRSISE TTTDSDIPI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.96084803796407	bayes_pls_golite062009
nucleic acid binding	2.69616509670156	bayes_pls_golite062009
protein binding	2.66176697577398	bayes_pls_golite062009
transcription regulator activity	2.19067997822967	bayes_pls_golite062009
protein transporter activity	2.04344254357091	bayes_pls_golite062009
DNA binding	1.96172460362671	bayes_pls_golite062009
RNA binding	1.78069099517213	bayes_pls_golite062009
structural molecule activity	1.66038601649515	bayes_pls_golite062009
transcription factor activity	1.21493607378314	bayes_pls_golite062009
transcription activator activity	1.11944470571412	bayes_pls_golite062009
cytoskeletal protein binding	0.66737572008694	bayes_pls_golite062009
translation regulator activity	0.642878560112121	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.620348955429476	bayes_pls_golite062009
protein transmembrane transporter activity	0.395743822582218	bayes_pls_golite062009
structure-specific DNA binding	0.384349606267362	bayes_pls_golite062009
substrate-specific transporter activity	0.36250570104201	bayes_pls_golite062009
translation initiation factor activity	0.286790642914928	bayes_pls_golite062009
nuclear localization sequence binding	0.135350548248851	bayes_pls_golite062009
mRNA binding	0.107084556647027	bayes_pls_golite062009
transcription factor binding	8.79739237675814E-4	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [690-1018]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKNNEHINID APMIAGDITL LGLDVILNTR IMGAKAFALT LSMFQDSTLQ SFFTNVLVRC  60
   61 LELPFSTPRM LAGIIVSQFC SSWLQKHPEG EKLPSFVSEI FSPVMNKQLL NRDEFPVFRE 120
  121 LVPSLKALRT QCQSLLATFV DVGMLPQYKL PNVAIVVQGE TEAGPHAFGV ETAEKVYGEY 180
  181 YDKMFKSMNN SYKLLAKKPL EDSKHRVLMA INSAKESAKL RTGSILANYA SSILLFDGLP 240
  241 LKLNPIIRSL MDSVKEERNE KLQTMAGESV VHLIQQLLEN NKVNVSGKIV KNLCGFLCVD 300
  301 TSEVPDFSVN AEYKEKILTL IKESNSIAA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.36915495988847	bayes_pls_golite062009
pyrophosphatase activity	2.29436982996465	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.27303683020046	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.27190707957159	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
ATPase activity	1.76238574289941	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
microtubule motor activity	1.6537049553461	bayes_pls_golite062009
ATPase activity, coupled	1.57826779898847	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.56989255954747	bayes_pls_golite062009
structural constituent of ribosome	1.47858140861683	bayes_pls_golite062009
RNA helicase activity	1.42791449104435	bayes_pls_golite062009
RNA-dependent ATPase activity	1.39335733374328	bayes_pls_golite062009
ATP-dependent RNA helicase activity	1.36724390116598	bayes_pls_golite062009
motor activity	1.34881124154297	bayes_pls_golite062009
protein-DNA loading ATPase activity	1.29640539057136	bayes_pls_golite062009
structure-specific DNA binding	1.2539059700735	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
DNA clamp loader activity	1.12431517057397	bayes_pls_golite062009
double-stranded DNA binding	1.117585097627	bayes_pls_golite062009
DNA-directed DNA polymerase activity	1.02269224635866	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA polymerase activity	0.987648886158896	bayes_pls_golite062009
hydrolase activity	0.98565595572967	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
structural molecule activity	0.86514677273731	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
purine nucleotide binding	0.725611289205392	bayes_pls_golite062009
nucleotide binding	0.717697610309727	bayes_pls_golite062009
purine ribonucleotide binding	0.713814218071151	bayes_pls_golite062009
ribonucleotide binding	0.713752628021599	bayes_pls_golite062009
ATP binding	0.60527666756293	bayes_pls_golite062009
adenyl ribonucleotide binding	0.573214556107072	bayes_pls_golite062009
single-stranded DNA binding	0.568457189190858	bayes_pls_golite062009
adenyl nucleotide binding	0.554530910579109	bayes_pls_golite062009
lysine N-acetyltransferase activity	0.551232230388384	bayes_pls_golite062009
histone acetyltransferase activity	0.551232230388384	bayes_pls_golite062009
transcription activator activity	0.537911793669378	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
	0.442119153778711	bayes_pls_golite062009
GTPase activity	0.437665353870877	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.407727781673696	bayes_pls_golite062009
mismatched DNA binding	0.31144582840038	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.243902356228423	bayes_pls_golite062009
substrate-specific transporter activity	0.144154288308693	bayes_pls_golite062009
centromeric DNA binding	0.120185906020979	bayes_pls_golite062009
active transmembrane transporter activity	0.114463153989353	bayes_pls_golite062009
microfilament motor activity	0.10236059675512	bayes_pls_golite062009
RNA binding	0.0261282189186349	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [1019-1198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDDINLAKMS EEAQLKRKGG LITLKILFEV LGPSILQKLP QLRSILFDSL SDHENEEASK  60
   61 VDNEQGQKIV DSFGVLRALF PFMSDSLRSS EVFTRFPVLL TFLRSNLSVF RYSAARTFAD 120
  121 LAKISSVEVM AYTIREILPL MNSAGSLSDR QGSTELIYHL SLSMETDVLP YVIFLIVPLL 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [1199-1269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRMSDSNEDV RNLATTTFAS IIKLVPLEAG IADPKGLPEE LVASRERERD FIQQMMDPSK  60
   61 AKPFKLPIAI K

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1270-1583]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATLRKYQQDG VNWLAFLNKY HLHGILCDDM GLGKTLQTIC IIASDQYLRK EDYEKTRSVE  60
   61 SRALPSLIIC PPSLTGHWEN EFDQYAPFLK VVVYAGGPTV RLTLRPQLSD ADIIVTSYDV 120
  121 ARNDLAVLNK TEYNYCVLDE GHIIKNSQSK LAKAVKEITA NHRLILTGTP IQNNVLELWS 180
  181 LFDFLMPGFL GTEKMFQERF AKPIAASRNS KTSSKEQEAG VLALEALHKQ VLPFMLRRLK 240
  241 EDVLSDLPPK IIQDYYCELG DLQKQLYMDF TKKQKNVVEK DIENSEIADG KQHIFQALQY 300
  301 MRKLCNHPAL VLSP

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	151.040959
Match:	PF00176
Description:	SNF2 family N-terminal domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [1584-1672]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NHPQLAQVQD YLKQTGLDLH DIINAPKLSA LRTLLFECGI GEEDIDKKAS QDQNFPIQNV  60
   61 ISQHRALIFC QLKDMLDMVE NDLFKKYMP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1673-1746]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVTYMRLDGS IDPRDRQKVV RKFNEDPSID CLLLTTKVGG LGLNLTGADT VIFVEHDWNP  60
   61 MNDLQAMDRA HRIG

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	24.638272
Match:	PF00271
Description:	Helicase conserved C-terminal domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1747-1867]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKKVVNVYRI ITKGTLEEKI MGLQKFKMNI ASTVVNQQNS GLASMDTHQL LDLFDPDNVT  60
   61 SQDNEEKNNG DSQAAKGMED IANETGLTGK AKEALGELKE LWDPSQYEEE YNLDTFIKTL 120
  121 R

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: