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View Structure Prediction Details

Protein: ISW2
Organism: Saccharomyces cerevisiae
Length: 1120 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISW2.

Description E-value Query
Range
Subject
Range
gi|30578398, gi|... - gi|30578398|ref|NP_444353.2| SWI/SNF related, matrix associated, actin dependent regulator of chroma...
0.0 [6..1079] [25..1039]
ISW2 - ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, f...
ISW2_YEAST - ISWI chromatin-remodeling complex ATPase ISW2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
0.0 [1..1120] [1..1120]
gi|11035016 - gi|11035016|gb|AAG01537.2|AF292095_1 imitation switch ISWI [Xenopus laevis]
0.0 [1..1104] [1..1043]
gi|21071058 - gi|21071058|ref|NP_003592.2| SWI/SNF-related matrix-associated actin-dependent regulator of chromati...
0.0 [1..1104] [1..1049]
Iswi-PA, Iswi-PB... - The gene Imitation SWI is referred to in FlyBase by the symbol Dmel\Iswi (CG8625, FBgn0011604). It i...
0.0 [57..1098] [13..1019]

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Predicted Domain #1
Region A:
Residues: [1-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTQQEEQRS DTKNSKSESP SEVLVDTLDS KSNGSSDDDN IGQSEELSDK EIYTVEDRPP  60
   61 EYWAQRKKKF VLDVDPKYAK QKDKSDTYKR FKYLLGVTDL FRHFIGIKAK HDKNIQKLLK 120
  121 QLDSDANKLS KSHSTVSSSS RHHRKTEKEE DAELMADEEE EIVDTYQEDI 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [171-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVSESPSFVK SGKLRDYQVQ GLNWLISLHE NKLSGILADE MGLGKTLQTI SFLGYLRYVK  60
   61 QIEGPFLIIV PKSTLDNWRR EFLKWTPNVN VLVLHGDKDT RADIVRNIIL EARFDVLITS 120
  121 YEMVIREKNA LKRLAWQYIV IDEAHRIKNE QSALSQIIRL FYSKNRLLIT GTPLQNNLHE 180
  181 LWALLNFLLP DIFGDSELFD EWFEQNNSEQ DQEIVIQQLH SVLNPFLLRR VKADVEKSLL 240
  241 PKIETNVYVG MTDMQIQWYK SL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 105.29243
Match: PF00176
Description: SNF2 family N-terminal domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 3.1726526166851 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.53262078944357 bayes_pls_golite062009
histone acetyltransferase activity 1.53262078944357 bayes_pls_golite062009
structural constituent of ribosome 1.47858140861683 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.29640539057136 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
purine ribonucleotide binding 1.21658213854831 bayes_pls_golite062009
ribonucleotide binding 1.21652144153182 bayes_pls_golite062009
purine nucleotide binding 1.21571071905795 bayes_pls_golite062009
nucleotide binding 1.20347573865566 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
DNA clamp loader activity 1.12431517057397 bayes_pls_golite062009
transcription elongation regulator activity 1.11383295816593 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription activator activity 0.889929694023098 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
structural molecule activity 0.86514677273731 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
steroid hormone receptor binding 0.647625526012423 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP binding 0.60527666756293 bayes_pls_golite062009
microtubule motor activity 0.60036517876321 bayes_pls_golite062009
adenyl ribonucleotide binding 0.573214556107072 bayes_pls_golite062009
adenyl nucleotide binding 0.554530910579109 bayes_pls_golite062009
sequence-specific DNA binding 0.543891899378373 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
guanyl nucleotide binding 0.388587892299301 bayes_pls_golite062009
guanyl ribonucleotide binding 0.372638007722845 bayes_pls_golite062009
GTP binding 0.364508542344128 bayes_pls_golite062009
hormone receptor binding 0.351501100511918 bayes_pls_golite062009
N-acetyltransferase activity 0.324427816547256 bayes_pls_golite062009
centromeric DNA binding 0.322818640526369 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
nuclear hormone receptor binding 0.246160342138071 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
GTPase activity 0.234351968078991 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
N-acyltransferase activity 0.117412028365885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [433-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEKDIDAVNG AVGKREGKTR LLNIVMQLRK CCNHPYLFEG AEPGPPYTTD EHLIFNSGKM  60
   61 II

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [495-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDKLLKRLKE KGSRVLIFSQ MSRLLDILED YCYFRDFEYC RIDGSTSHEE RIEAIDEYNK  60
   61 PNSEKFVFLL TTRAGGLGIN LVTADTVILF DSDWNPQADL QAMDRAHRIG QKKQVHVYRF 120
  121 VTENAIEEKV IERAAQKLRL DQLVIQQGTG KKTASLGNSK DDLLDMIQFG AKNMFEKKAS 180
  181 KVTVDADIDD ILKKGEQKTQ ELNAKYQSLG LDDLQKFNGI ENQSAYEW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1d9xA_
Description: Nucleotide excision repair enzyme UvrB
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [723-889]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGKSFQKKSN DKVVEWINPS RRERRREQTT YSVDDYYKEI IGGGSKSASK QTPQPKAPRA  60
   61 PKVIHGQDFQ FFPKELDALQ EKEQLYFKKK VNYKVTSYDI TGDIRNEGSD AEEEEGEYKN 120
  121 AANTEGHKGH EELKRRIEEE QEKINSAPDF TQEDELRKQE LISKAFT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [890-1120]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NWNKRDFMAF INACAKYGRD DMENIKKSID SKTPEEVEVY AKIFWERLKE INGWEKYLHN  60
   61 VELGEKKNEK LKFQETLLRQ KIEQCKHPLH ELIIQYPPNN ARRTYNTLED KFLLLAVNKY 120
  121 GLRADKLYEK LKQEIMMSDL FTFDWFIKTR TVHELSKRVH TLLTLIVREY EQPDANKKKR 180
  181 SRTSATREDT PLSQNESTRA STVPNLPTTM VTNQKDTNDH VDKRTKIDQE A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle