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Protein Overview: ISW2_YEAST

General Information:
Name(s) found: ISW2_YEAST [Swiss-Prot]
Description(s) found:
  • ISWI chromatin-remodeling complex ATPase ISW2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISW2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1120 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTQQEEQRS DTKNSKSESP SEVLVDTLDS KSNGSSDDDN IGQSEELSDK EIYTVEDRPP  60
   61 EYWAQRKKKF VLDVDPKYAK QKDKSDTYKR FKYLLGVTDL FRHFIGIKAK HDKNIQKLLK 120
  121 QLDSDANKLS KSHSTVSSSS RHHRKTEKEE DAELMADEEE EIVDTYQEDI FVSESPSFVK 180
  181 SGKLRDYQVQ GLNWLISLHE NKLSGILADE MGLGKTLQTI SFLGYLRYVK QIEGPFLIIV 240
  241 PKSTLDNWRR EFLKWTPNVN VLVLHGDKDT RADIVRNIIL EARFDVLITS YEMVIREKNA 300
  301 LKRLAWQYIV IDEAHRIKNE QSALSQIIRL FYSKNRLLIT GTPLQNNLHE LWALLNFLLP 360
  361 DIFGDSELFD EWFEQNNSEQ DQEIVIQQLH SVLNPFLLRR VKADVEKSLL PKIETNVYVG 420
  421 MTDMQIQWYK SLLEKDIDAV NGAVGKREGK TRLLNIVMQL RKCCNHPYLF EGAEPGPPYT 480
  481 TDEHLIFNSG KMIILDKLLK RLKEKGSRVL IFSQMSRLLD ILEDYCYFRD FEYCRIDGST 540
  541 SHEERIEAID EYNKPNSEKF VFLLTTRAGG LGINLVTADT VILFDSDWNP QADLQAMDRA 600
  601 HRIGQKKQVH VYRFVTENAI EEKVIERAAQ KLRLDQLVIQ QGTGKKTASL GNSKDDLLDM 660
  661 IQFGAKNMFE KKASKVTVDA DIDDILKKGE QKTQELNAKY QSLGLDDLQK FNGIENQSAY 720
  721 EWNGKSFQKK SNDKVVEWIN PSRRERRREQ TTYSVDDYYK EIIGGGSKSA SKQTPQPKAP 780
  781 RAPKVIHGQD FQFFPKELDA LQEKEQLYFK KKVNYKVTSY DITGDIRNEG SDAEEEEGEY 840
  841 KNAANTEGHK GHEELKRRIE EEQEKINSAP DFTQEDELRK QELISKAFTN WNKRDFMAFI 900
  901 NACAKYGRDD MENIKKSIDS KTPEEVEVYA KIFWERLKEI NGWEKYLHNV ELGEKKNEKL 960
  961 KFQETLLRQK IEQCKHPLHE LIIQYPPNNA RRTYNTLEDK FLLLAVNKYG LRADKLYEKL1020
 1021 KQEIMMSDLF TFDWFIKTRT VHELSKRVHT LLTLIVREYE QPDANKKKRS RTSATREDTP1080
 1081 LSQNESTRAS TVPNLPTTMV TNQKDTNDHV DKRTKIDQEA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] MSA 1.482995 View MSA. No confident structure predictions are available.
    2 View Details [171..432] Pfam 105.29243 SNF2 family N-terminal domain No confident structure predictions are available.
    3 View Details [433..494] PSI-BLAST 4.522879 Putative DEAD box RNA helicase
    4 View Details [495..722] PSI-BLAST 2.69897 Nucleotide excision repair enzyme UvrB
    5 View Details [723..889] MSA 2.211994 View MSA. No confident structure predictions are available.
    6 View Details [890..1120] MSA 1.066996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.1726526166851 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.53262078944357 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.53262078944357 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.29640539057136 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.21658213854831 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.21652144153182 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.21571071905795 bayes_pls_golite062009
  • nucleotide binding
    		•  1.20347573865566 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  1.12431517057397 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.11383295816593 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription activator activity
    		•  0.889929694023098 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.647625526012423 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • ATP binding
    		•  0.60527666756293 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.60036517876321 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.573214556107072 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.554530910579109 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.543891899378373 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.388587892299301 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.372638007722845 bayes_pls_golite062009
  • GTP binding
    		•  0.364508542344128 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.351501100511918 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.324427816547256 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.246160342138071 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • GTPase activity
    		•  0.234351968078991 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.117412028365885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle