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View Structure Prediction Details

Protein: YPK1
Organism: Saccharomyces cerevisiae
Length: 680 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPK1.

Description E-value Query
Range		 Subject
Range
YPK1_YEAST - Serine/threonine-protein kinase YPK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPK...
YPK1 - Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; muta...
 0.0 [1..680] [1..680]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [1..680] [1..680]
gi|9716257 - gi|9716257|emb|CAC01625.1| protein kinase C homologue [Tuber borchii]
 0.0 [13..666] [520..1134]
gi|458284 - gi|458284|gb|AAA57318.1| serine/threonine protein kinase
 0.0 [70..667] [52..640]
PRKCB1 - protein kinase C, beta 1
 0.0 [193..669] [180..668]
KPCB_RABIT - Protein kinase C beta type OS=Oryctolagus cuniculus GN=PRKCB PE=2 SV=3
 0.0 [193..669] [180..668]

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Predicted Domain #1
Region A:
Residues: [1-152] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSWKSKFKF GKSKEEKEAK HSGFFHSSKK EEQQNNQATA GEHDASITRS SLDRKGTINP  60
   61 SNSSVVPVRV SYDASSSTST VRDSNGGNSE NTNSSQNLDE TANIGSTGTP NDATSSSGMM 120
  121 TIKVYNGDDF ILPFPITSSE QILNKLLASG VP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
tau-protein kinase activity 2.00481226596005 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
tubulin binding 1.13686658158825 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
ErbB-2 class receptor binding 1.02996109010965 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
nucleic acid binding 0.794058505655489 bayes_pls_golite062009
transcription regulator activity 0.775404673285876 bayes_pls_golite062009
microtubule binding 0.734274677384472 bayes_pls_golite062009
DNA binding 0.714163549867672 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.688047400629641 bayes_pls_golite062009
vinculin binding 0.666656406096231 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transcription factor activity 0.563262875317016 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.15809676511862 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [153-305] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPHKEISKEV DALIAQLSRV QIKNQGPADE DLISSESAAK FIPSTIMLPG SSTLNPLLYF  60
   61 TIEFDNTVAT IEAEYGTIAK PGFNKISTFD VTRKLPYLKI DVFARIPSIL LPSKTWQQEM 120
  121 GLQDEKLQTI FDKINSNQDI HLDSFHLPIN LSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1a25A_
Description: C2 domain from protein kinase c (beta)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [306-338] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSAASIRLYN HHWITLDNGL GKINISIDYK PSR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [390-410] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 THTLAERTVL ARVDCPFIVP L

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [426-627] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FINGGELFYH LQKEGRFDLS RARFYTAELL CALDNLHKLD VVYRDLKPEN ILLDYQGHIA  60
   61 LCDFGLCKLN MKDDDKTDTF CGTPEYLAPE LLLGLGYTKA VDWWTLGVLL YEMLTGLPPY 120
  121 YDEDVPKMYK KILQEPLVFP DGFDRDAKDL LIGLLSRDPT RRLGYNGADE IRNHPFFSQL 180
  181 SWKRLLMKGY IPPYKPAVSN SM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 890.0
Match: 1atpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [339-389] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPLSIDDFD LLKVIGKGSF GKVMQVRKKD TQKVYALKAI RKSYIVSKSE V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [411-425] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFSFQSPEKL YFVLA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [628-680] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTSNFDEEFT REKPIDSVVD EYLSESVQKQ FGGWTYVGNE QLGSSMVQGR SIR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 890.0
Match: 1atpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle