YRC Public Data Repository - Protein Structure Prediction

Protein:	PTK2
Organism:	Saccharomyces cerevisiae
Length:	818 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTK2.

Description	E-value	Query Range	Subject Range
PTK2 - Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membr... PTK2_YEAST - Serine/threonine-protein kinase PTK2/STK2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...	0.0	[1..818]	[1..818]
gi\|15289758 - gi\|15289758\|dbj\|BAB63463.1\| calcium dependent protein kinase [Solanum tuberosum]	0.0	[126..760]	[1..569]
gi\|16215471 - gi\|16215471\|emb\|CAC82999.1\| calcium-dependent protein kinase 3 [Nicotiana tabacum]	0.0	[126..760]	[1..569]
gi\|16215475 - gi\|16215475\|emb\|CAC83000.1\| calcium-dependent protein kinase 2 [Nicotiana benthamiana]	0.0	[126..760]	[1..572]
CDPKH_ARATH - Calcium-dependent protein kinase 17 OS=Arabidopsis thaliana GN=CPK17 PE=2 SV=1	0.0	[185..755]	[3..526]
gi\|13561063 - gi\|13561063\|emb\|CAA65500.1\| protein kinase [Medicago sativa]	0.0	[168..748]	[6..538]

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Predicted Domain #1

Region A:
Residues: [1-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNGKDKEV DKSPSVSTLK LLGKRLFNSS SHTDNSSLLL SAEQLGNGRS LRKRPTSPSI  60
   61 SGSGSGGNSP SSSAGARQRS ASLHRRKNNA SVGFSNGSVS SHKSSVALQD LIKHNNNPYL 120
  121 NSPSDILGTG TGIASTRDRD RAVLDREKEK ERARNKERNT HHAGLPQRSN SMASHHFPNE 180
  181 NIVYNPYGIS PNHARPDTAF ADTLNTNKEN DLSFYMHDGN SKIRM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
acetylcholine receptor activator activity	5.9159846946654	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	3.41480681854114	bayes_pls_golite062009
transmembrane receptor protein kinase activity	3.40140621607334	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.94085498993561	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
small conjugating protein ligase activity	1.74206248731815	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
growth factor binding	1.53863828216563	bayes_pls_golite062009
ErbB-3 class receptor binding	1.34841233233438	bayes_pls_golite062009
ErbB-2 class receptor binding	1.33825339298024	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.25285260301349	bayes_pls_golite062009
epidermal growth factor receptor binding	1.24312972088703	bayes_pls_golite062009
acid-amino acid ligase activity	1.2266791546014	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity	1.11664317075762	bayes_pls_golite062009
transforming growth factor beta receptor activity	1.10045286406485	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	1.10045286406485	bayes_pls_golite062009
vinculin binding	1.06656350652527	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
insulin receptor substrate binding	0.98689034826741	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
nucleic acid binding	0.794058505655489	bayes_pls_golite062009
transcription regulator activity	0.775404673285876	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.75189004129952	bayes_pls_golite062009
DNA binding	0.714163549867672	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transcription repressor activity	0.568332175782799	bayes_pls_golite062009
transcription factor activity	0.563262875317016	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.51726292539973	bayes_pls_golite062009
activin binding	0.510364757301021	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
structural constituent of muscle	0.399773397398032	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
tubulin binding	0.385009627613955	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.188254408239569	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009
brain-derived neurotrophic factor binding	0.00315481858218991	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [226-343]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLPIANPND FLPEDMKQYS VHLTDNFVFD TDNKPIGSGG SSEVRKVKSS YRQKDVYALK  60
   61 KLNMIYHESP EKFYKRCSKE FIIAKHLSHN VHITNTFYLL KVPTTTYTTR GWGFIMEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	256.9897
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [344-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVKDLFQLME RTGWKNVPFN EKYCLFKQVA QGIKFCHDNG IAHRDLKPEN VLISKEGICK  60
   61 LTDFGISDWY HVIPHDYTSP V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [564-584]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIETCVEPND DDLVRVPELR K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	256.9897
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [425-493]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTCQGMIGSP PYTPPEVMYF DAKKHYPEKF QKPYNPLAMD SYALGIMLIT MINNIIPFID  60
   61 SCNTDARFR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	256.9897
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [494-563]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFEVSYDNFI NHQNPHFRDK GCHKPGPGSE YSLARNFKNT DATRIAWRLA DPNPATRYTM  60
   61 DDLFNDPFFQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	256.9897
Match:	1aq1__
Description:	Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [585-671]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STSTNDFSEN SLDAPHDQEV IHTSNPFLKK ETLTSKPRSM LEIAESPSLK QKSKVKDSAK  60
   61 TKTHDVGDEG GNESTKPKQQ DKKENLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.0
Match:	1a29__
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [672-760]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDEVKNGDKD KVIEEATTTN VDSILEKPTP TSTKVEDNLS EDDSTMKELK SMLNSTPTTP  60
   61 THNGPTPLPA KAGTQLDKRM SDLSLKSET

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.0
Match:	1a29__
Description:	Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [761-818]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASTKNFSAP NVSSSSNSLR SLGSPSVSSS KKKKVIHHHL DITNSVTNMS SVSAFISR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.525	0.920	G1/S transition of mitotic cell cycle	a.4.1	Homeodomain-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: