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View Structure Prediction Details

Protein: DUN1
Organism: Saccharomyces cerevisiae
Length: 513 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DUN1.

Description E-value Query
Range		 Subject
Range
DUN1 - Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certa...
DUN1_YEAST - DNA damage response protein kinase DUN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
 0.0 [1..513] [1..513]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [99..513] [9..396]
gi|18175903 - gi|18175903|gb|AAL59948.1| putative calcium-dependent protein kinase [Arabidopsis thaliana]
 0.0 [150..511] [22..357]
KS6AA_CHICK - Ribosomal protein S6 kinase 2 alpha OS=Gallus gallus GN=RPS6KA PE=2 SV=1
 0.0 [81..511] [301..723]
KS6A1_RAT - Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus GN=Rps6ka1 PE=1 SV=1
 0.0 [81..511] [283..706]
tr|M3WDY3|M3WDY3... - Ribosomal protein S6 kinase OS=Felis catus GN=RPS6KA3 PE=3 SV=1
gi|183396847 - gi|183396847|gb|AAI65985.1| Ribosomal protein S6 kinase polypeptide 3 [synthetic construct]
KS6A3_MOUSE - Ribosomal protein S6 kinase alpha-3 OS=Mus musculus GN=Rps6ka3 PE=1 SV=2
gi|154707846, gi... - gi|154707846|ref|NP_001092407.1| ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Bos taurus], gi|...
 0.0 [81..511] [182..604]
gi|148228921, gi... - gi|6537166|gb|AAF15553.1|AF165162_1 Rsk-2 [Xenopus laevis], gi|51258315|gb|AAH80017.1| RSK2 protein ...
 0.0 [81..511] [286..707]
RPS6KA3 - ribosomal protein S6 kinase, 90kDa, polypeptide 3
ENSCJAT00000010341 - null
 0.0 [81..511] [289..711]

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Predicted Domain #1
Region A:
Residues: [1-152] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSTKREHS GDVTDSSFKR QQRSNKPSSE YTCLGHLVNL IPGKEQKVEI TNRNVTTIGR  60
   61 SRSCDVILSE PDISTFHAEF HLLQMDVDNF QRNLINVIDK SRNGTFINGN RLVKKDYILK 120
  121 NGDRIVFGKS CSFLFKYASS SSTDIENDDE KV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.39794
Match: 1gxcA_
Description: Chk2 kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.6561903894619 bayes_pls_golite062009
protein binding 3.44553762357492 bayes_pls_golite062009
transcription regulator activity 3.23926962992034 bayes_pls_golite062009
DNA binding 3.12131448113144 bayes_pls_golite062009
nucleic acid binding 2.91028042727128 bayes_pls_golite062009
histone binding 2.79033314021304 bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity 2.78221661189523 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity 2.56188495627199 bayes_pls_golite062009
receptor signaling protein activity 2.25132862320271 bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity 2.06369312345519 bayes_pls_golite062009
structure-specific DNA binding 1.95921851331594 bayes_pls_golite062009
transcription factor activity 1.89464382469326 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.88096476099716 bayes_pls_golite062009
double-stranded DNA binding 1.84746485315093 bayes_pls_golite062009
kinase activity 1.82476774968305 bayes_pls_golite062009
sequence-specific DNA binding 1.78280248668052 bayes_pls_golite062009
DNA replication origin binding 1.78246425241581 bayes_pls_golite062009
protein kinase activity 1.73373132141588 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.66058356077795 bayes_pls_golite062009
SMAD binding 1.58868248655216 bayes_pls_golite062009
type I transforming growth factor beta receptor binding 1.58437603150322 bayes_pls_golite062009
transcription repressor activity 1.5642245057124 bayes_pls_golite062009
transcription activator activity 1.53960544319629 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48483625404671 bayes_pls_golite062009
promoter binding 1.34105825186678 bayes_pls_golite062009
transferase activity 1.29860325699399 bayes_pls_golite062009
protein serine/threonine kinase activity 1.1868962075754 bayes_pls_golite062009
transcription factor binding 0.93544177518754 bayes_pls_golite062009
small conjugating protein ligase activity 0.9108432673413 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.90981150861416 bayes_pls_golite062009
molecular transducer activity 0.767071864136971 bayes_pls_golite062009
signal transducer activity 0.767071864136971 bayes_pls_golite062009
R-SMAD binding 0.70816286022176 bayes_pls_golite062009
chromatin binding 0.62935034847038 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 0.459063012088486 bayes_pls_golite062009
transforming growth factor beta receptor binding 0.459063012088486 bayes_pls_golite062009
enzyme binding 0.34998623523914 bayes_pls_golite062009
protein dimerization activity 0.33340925100096 bayes_pls_golite062009
co-SMAD binding 0.325865547214071 bayes_pls_golite062009
damaged DNA binding 0.279328480488455 bayes_pls_golite062009
collagen binding 0.241950844569571 bayes_pls_golite062009
receptor serine/threonine kinase binding 0.121846363304069 bayes_pls_golite062009
receptor binding 0.0581553668794451 bayes_pls_golite062009
identical protein binding 0.0513801649373811 bayes_pls_golite062009
protein homodimerization activity 0.0339057097360133 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [153-287] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSESRSYKND DEVFKKPQIS ATSSQNATTS AAIRKLNKTR PVSFFDKYLL GKELGAGHYA  60
   61 LVKEAKNKKT GQQVAVKIFH AQQNDDQKKN KQFREETNIL MRVQHPNIVN LLDSFVEPIS 120
  121 KSQIQKYLVL EKIDD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [501-513] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKIPKTYSEL SCL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 636.457575
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
actin binding 2.37384162366989 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
telethonin binding 2.27062712605521 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
alpha-actinin binding 1.38861866085902 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
transcription regulator activity 1.30988141770642 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
actin filament binding 1.20555646820348 bayes_pls_golite062009
DNA binding 1.17130513163489 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transcription repressor activity 0.959888295228949 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
transcription factor activity 0.919430701010326 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.51726292539973 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
protein complex binding 0.343240719858581 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [288-500] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GELFERIVRK TCLRQDESKA LFKQLLTGLK YLHEQNIIHR DIKPENILLN ITRRENPSQV  60
   61 QLGPWDEDEI DIQVKIADFG LAKFTGEMQF TNTLCGTPSY VAPEVLTKKG YTSKVDLWSA 120
  121 GVILYVCLCG FPPFSDQLGP PSLKEQILQA KYAFYSPYWD KIDDSVLHLI SNLLVLNPDE 180
  181 RYNIDEALNH PWFNDIQQQS SVSLELQRLQ ITD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 636.457575
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle