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View Structure Prediction Details

Protein: CDC7
Organism: Saccharomyces cerevisiae
Length: 507 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC7.

Description E-value Query
Range		 Subject
Range
CDC7_YEAST - Cell division control protein 7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC7 PE=...
CDC7 - DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progr...
 0.0 [1..507] [1..507]
CDC2_OXYRB - Cell division control protein 2 homolog OS=Oxybasis rubra GN=CDC2 PE=2 SV=1
 0.0 [30..299] [1..273]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [30..299] [1..273]
gi|4096103 - gi|4096103|gb|AAD10483.1| p34cdc2 [Triticum aestivum]
 0.0 [30..298] [1..272]
CDC21_ORYSA, CC2... - Cell division control protein 2 homolog 1 (EC 2.7.11.22) - Oryza sativa (Rice), (P29618) Cell divisi...
CDKA1_ORYSJ - Cyclin-dependent kinase A-1 OS=Oryza sativa subsp. japonica GN=CDKA-1 PE=1 SV=1
 0.0 [30..298] [1..272]
CDC2_MAIZE - Cell division control protein 2 homolog OS=Zea mays GN=CDC2 PE=2 SV=1
 0.0 [30..299] [1..273]
CDC2A_ANTMA - Cell division control protein 2 homolog A OS=Antirrhinum majus GN=CDC2A PE=2 SV=2
 0.0 [30..299] [1..273]

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Predicted Domain #1
Region A:
Residues: [1-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA KDITGKITKK  60
   61 FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS SRVAPLCDAK RVRDQVIAVL 120
  121 PY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 243.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
acetylcholine receptor activator activity 3.57683141337465 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
tau-protein kinase activity 2.37138140221719 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
molecular transducer activity 1.79921740914853 bayes_pls_golite062009
signal transducer activity 1.79921740914853 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.70788499622067 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.68012041942855 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
insulin receptor substrate binding 0.98689034826741 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.938271345744087 bayes_pls_golite062009
transmembrane receptor activity 0.913893847407112 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
receptor activity 0.775180603313375 bayes_pls_golite062009
transporter activity 0.595111702412257 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
transmembrane transporter activity 0.41384976209545 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
axon guidance receptor activity 0.330635248803668 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.19622756073807 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.19622756073807 bayes_pls_golite062009
growth factor binding 0.153144089598532 bayes_pls_golite062009
substrate-specific transporter activity 0.0922946791401962 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [123-200] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPHEEFRTFY RDLPIKGIKK YIWELLRALK FVHSKGIIHR DIKPTNFLFN LELGRGVLVD  60
   61 FGLAEAQMDY KSMISSQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 243.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [201-252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP PMVTIQNGKV VH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 243.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [253-304] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNNVNGVDLT KGYPKNETRR IKRANRAGTR GFRAPEVLMK CGAQSTKIDI WS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 243.0
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [305-422] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVILLSLLG RRFPMFQSLD DADSLLELCT IFGWKELRKC AALHGLGFEA SGLIWDKPNG  60
   61 YSNGLKEFVY DLLNKECTIG TFPEYSVAFE TFGFLQQELH DRMSIEPQLP DPKTNMDA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.722 0.202 DNA replication initiation a.133.1 Phospholipase A2, PLA2
View Download 0.248 0.068 DNA replication initiation d.2.1 Lysozyme-like
View Download 0.224 0.022 DNA replication initiation d.109.1 Actin depolymerizing proteins
View Download 0.343 0.014 DNA replication initiation a.47.2 t-snare proteins
View Download 0.247 0.005 DNA replication initiation a.60.9 lambda integrase-like, N-terminal domain
View Download 0.218 N/A N/A e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.215 N/A N/A d.42.1 POZ domain
View Download 0.213 N/A N/A a.2.3 Chaperone J-domain

Predicted Domain #6
Region A:
Residues: [423-507] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDAYELKKYQ EEIWSDHYWC FQVLEQCFEM DPQKRSSAED LLKTPFFNEL NENTYLLDGE  60
   61 STDEDDVVSS SEADLLDKDV LLISE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.480 a.74.1 Cyclin-like
View Download 0.397 a.21.1 HMG-box
View Download 0.431 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.621 a.64.2 Bacteriocin AS-48
View Download 0.343 a.74.1 Cyclin-like
View Download 0.335 a.21.1 HMG-box
View Download 0.274 a.74.1 Cyclin-like
View Download 0.266 d.79.5 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF
View Download 0.248 a.4.1 Homeodomain-like
View Download 0.247 a.4.5 "Winged helix" DNA-binding domain
View Download 0.239 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.231 a.39.1 EF-hand
View Download 0.225 a.4.1 Homeodomain-like
View Download 0.215 a.21.1 HMG-box
View Download 0.212 a.24.17 Group V grass pollen allergen

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle