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View Structure Prediction Details

Protein: gi|61354718, gi|...
Organism: synthetic construct
Length: 1342 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|61354718, gi|....

Description E-value Query
Range		 Subject
Range
gi|306841 - gi|306841|gb|AAA35979.1| HER3 protein precursor
 0.0 [1..1342] [1..1342]
gi|114644292 - gi|114644292|ref|XP_509131.2| PREDICTED: erbB-3 isoform 2 [Pan troglodytes]
 0.0 [1..1342] [1..1342]
gi|109097225 - gi|109097225|ref|XP_001113953.1| PREDICTED: erbB-3 isoform 4 [Macaca mulatta]
 0.0 [1..1342] [1..1342]
ERBB3_PONAB - Receptor tyrosine-protein kinase erbB-3 OS=Pongo abelii GN=ERBB3 PE=2 SV=1
ERBB3_PONPY - Receptor tyrosine-protein kinase erbB-3 precursor - Pongo pygmaeus (Orangutan)
 0.0 [1..1342] [1..1342]
ERBB3_MOUSE - Receptor tyrosine-protein kinase erbB-3 OS=Mus musculus GN=Erbb3 PE=1 SV=2
 0.0 [1..1341] [1..1338]
ERBB3_RAT - Receptor tyrosine-protein kinase erbB-3 OS=Rattus norvegicus GN=Erbb3 PE=1 SV=3
 0.0 [1..1342] [1..1339]
gi|73968297 - gi|73968297|ref|XP_538226.2| PREDICTED: similar to Receptor tyrosine-protein kinase erbB-3 precursor...
 0.0 [1..1342] [206..1536]

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Predicted Domain #1
Region A:
Residues: [1-666] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM  60
   61 GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120
  121 LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 180
  181 RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 240
  241 TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 300
  301 CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 360
  361 LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420
  421 RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TKVLRGPTEE 480
  481 RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 540
  541 REFAHEAECF SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI 600
  601 YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA GLVVIFMMLG 660
  661 GTFLYW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1m6bA
Description: Receptor protein-tyrosine kinase Erbb-3 extracellular domain; Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
insulin-like growth factor binding 6.22969465792364 bayes_pls_golite062009
nitric-oxide synthase regulator activity 5.70266126834184 bayes_pls_golite062009
insulin-like growth factor I binding 5.38913524516117 bayes_pls_golite062009
growth factor binding 5.25925494280191 bayes_pls_golite062009
insulin-like growth factor II binding 4.12089913732676 bayes_pls_golite062009
epidermal growth factor receptor activity 3.78895179350059 bayes_pls_golite062009
binding 3.10942625145915 bayes_pls_golite062009
G-protein coupled receptor activity 3.09281229196379 bayes_pls_golite062009
protein binding 3.04595153576805 bayes_pls_golite062009
extracellular matrix structural constituent 2.24697345620464 bayes_pls_golite062009
cytoskeletal protein binding 2.17861327763673 bayes_pls_golite062009
transmembrane receptor activity 2.11274485218746 bayes_pls_golite062009
actin binding 2.0879486757089 bayes_pls_golite062009
receptor activity 2.04770371945982 bayes_pls_golite062009
structural molecule activity 1.83189461928225 bayes_pls_golite062009
signal transducer activity 1.716940423168 bayes_pls_golite062009
molecular transducer activity 1.716940423168 bayes_pls_golite062009
enzyme regulator activity 1.68559458458962 bayes_pls_golite062009
protein kinase activity 1.64316913174221 bayes_pls_golite062009
protein tyrosine phosphatase activator activity 1.57541239141181 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.50579173120225 bayes_pls_golite062009
enzyme activator activity 1.49158544951255 bayes_pls_golite062009
nucleic acid binding 1.48507116784838 bayes_pls_golite062009
receptor binding 1.38917750110812 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.3823186140816 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.36671598599873 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.35826958219514 bayes_pls_golite062009
kinase activity 1.33897988039058 bayes_pls_golite062009
phosphatase activator activity 1.23699452328993 bayes_pls_golite062009
glycosaminoglycan binding 1.07723307116004 bayes_pls_golite062009
actin filament binding 0.987222190475555 bayes_pls_golite062009
extracellular matrix binding 0.907118880836251 bayes_pls_golite062009
protein tyrosine kinase activity 0.625443680166071 bayes_pls_golite062009
heparin binding 0.590238200498242 bayes_pls_golite062009
protein phosphatase binding 0.5845342946602 bayes_pls_golite062009
polysaccharide binding 0.57648672048391 bayes_pls_golite062009
phosphatase binding 0.479382571752751 bayes_pls_golite062009
epidermal growth factor receptor binding 0.430075899423884 bayes_pls_golite062009
protein-hormone receptor activity 0.42902267001067 bayes_pls_golite062009
pattern binding 0.339536765321749 bayes_pls_golite062009
glycoprotein binding 0.27885603541101 bayes_pls_golite062009
catalytic activity 0.271811389148807 bayes_pls_golite062009
hormone binding 0.10824213144683 bayes_pls_golite062009
collagen binding 0.085405748322021 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [667-991] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGRRIQNKRA MRRYLERGES IEPLDPSEKA NKVLARIFKE TELRKLKVLG SGVFGTVHKG  60
   61 VWIPEGESIK IPVCIKVIED KSGRQSFQAV TDHMLAIGSL DHAHIVRLLG LCPGSSLQLV 120
  121 TQYLPLGSLL DHVRQHRGAL GPQLLLNWGV QIAKGMYYLE EHGMVHRNLA ARNVLLKSPS 180
  181 QVQVADFGVA DLLPPDDKQL LYSEAKTPIK WMALESIHFG KYTHQSDVWS YGVTVWELMT 240
  241 FGAEPYAGLR LAEVPDLLEK GERLAQPQIC TIDVYMVMVK CWMIDENIRP TFKELANEFT 300
  301 RMARDPPRYL VIKRESGPGI APGPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.30103
Match: 1xkkA
Description: EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
nitric-oxide synthase regulator activity 5.44200869948164 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.04467222534257 bayes_pls_golite062009
kinase activity 4.85903980916957 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
epidermal growth factor receptor activity 3.94068388872775 bayes_pls_golite062009
phosphoinositide 3-kinase binding 3.43994026029707 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 3.26784640416242 bayes_pls_golite062009
transmembrane receptor activity 3.1965684217331 bayes_pls_golite062009
SH2 domain binding 3.03401803018883 bayes_pls_golite062009
PTB domain binding 3.02789234463297 bayes_pls_golite062009
receptor activity 2.96273889901429 bayes_pls_golite062009
signal transducer activity 2.85730457922199 bayes_pls_golite062009
molecular transducer activity 2.85730457922199 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transferase activity 2.34875558765742 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
insulin-like growth factor receptor binding 2.18795259566024 bayes_pls_golite062009
transforming growth factor beta receptor activity 2.1677218320705 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 2.1677218320705 bayes_pls_golite062009
insulin receptor activity 2.13530536490053 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
brain-derived neurotrophic factor binding 1.68652792375997 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.66669268613198 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.59883083492481 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
amine binding 1.3051205627964 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
insulin binding 1.23861703046323 bayes_pls_golite062009
activin binding 1.22461306010416 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
structural molecule activity 1.10436308210353 bayes_pls_golite062009
ErbB-2 class receptor binding 1.06651320735249 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
transcription regulator activity 1.03817708087796 bayes_pls_golite062009
receptor binding 0.990272341309676 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
nucleic acid binding 0.964782792058349 bayes_pls_golite062009
DNA binding 0.923923660104752 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.880236579821909 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 0.830144030420023 bayes_pls_golite062009
insulin-like growth factor binding 0.82854091092242 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
activin receptor activity 0.811117252475389 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
transcription factor activity 0.746157953046096 bayes_pls_golite062009
growth factor activity 0.707777793848936 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
MAP/ERK kinase kinase activity 0.678816830701899 bayes_pls_golite062009
transcription activator activity 0.645254722299306 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
MAP kinase kinase activity 0.610230065465794 bayes_pls_golite062009
Janus kinase activity 0.580310109637219 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.546647574638943 bayes_pls_golite062009
cytokine receptor binding 0.516151105278102 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
tubulin binding 0.385009627613955 bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding 0.372842462336059 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
cell adhesion molecule binding 0.150740450460731 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
activin receptor activity, type I 0.117759584117941 bayes_pls_golite062009
JUN kinase kinase kinase activity 0.0613131034808199 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.0386657159233388 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [992-1064] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHGLTNKKLE EVELEPELDL DLDLEAEEDN LATTTLGSAL SLPVGTLNRP RGSQSLLSPS  60
   61 SGYMPMNQGN LGE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [1065-1157] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCQESAVSGS SERCPRPVSL HPMPRGCLAS ESSEGHVTGS EAELQEKVSM CRSRSRSRSP  60
   61 RPRGDSAYHS QRHSLLTPVT PLSPPGLEEE DVN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1158-1342] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYVMPDTHLK GTPSSREGTL SSVGLSSVLG TEEEDEDEEY EYMNRRRRHS PPHPPRPSSL  60
   61 EELGYEYMDV GSDLSASLGS TQSCPLHPVP IMPTAGTTPD EDYEYMNRQR DGGGPGGDYA 120
  121 AMGACPASEQ GYEEMRAFQG PGHQAPHVHY ARLKTLRSLE ATDSAFDNPD YWHSRLFPKA 180
  181 NAQRT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle