YRC Public Data Repository - Protein Structure Prediction

Protein:	YPK1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	680 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPK1_YEAST.

Description	E-value	Query Range	Subject Range
YPK1_YEAST - Serine/threonine-protein kinase YPK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPK... YPK1 - Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; muta...	0.0	[1..680]	[1..680]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[1..680]	[1..680]
gi\|9716257 - gi\|9716257\|emb\|CAC01625.1\| protein kinase C homologue [Tuber borchii]	0.0	[13..666]	[520..1134]
gi\|458284 - gi\|458284\|gb\|AAA57318.1\| serine/threonine protein kinase	0.0	[70..667]	[52..640]
PRKCB1 - protein kinase C, beta 1	0.0	[193..669]	[180..668]
KPCB_RABIT - Protein kinase C beta type OS=Oryctolagus cuniculus GN=PRKCB PE=2 SV=3	0.0	[193..669]	[180..668]

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Predicted Domain #1

Region A:
Residues: [1-152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSWKSKFKF GKSKEEKEAK HSGFFHSSKK EEQQNNQATA GEHDASITRS SLDRKGTINP  60
   61 SNSSVVPVRV SYDASSSTST VRDSNGGNSE NTNSSQNLDE TANIGSTGTP NDATSSSGMM 120
  121 TIKVYNGDDF ILPFPITSSE QILNKLLASG VP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
tau-protein kinase activity	2.00481226596005	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
tubulin binding	1.13686658158825	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
ErbB-2 class receptor binding	1.02996109010965	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
nucleic acid binding	0.794058505655489	bayes_pls_golite062009
transcription regulator activity	0.775404673285876	bayes_pls_golite062009
microtubule binding	0.734274677384472	bayes_pls_golite062009
DNA binding	0.714163549867672	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	0.688047400629641	bayes_pls_golite062009
vinculin binding	0.666656406096231	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transcription factor activity	0.563262875317016	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
receptor binding	0.197402253061255	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.15809676511862	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [153-305]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPHKEISKEV DALIAQLSRV QIKNQGPADE DLISSESAAK FIPSTIMLPG SSTLNPLLYF  60
   61 TIEFDNTVAT IEAEYGTIAK PGFNKISTFD VTRKLPYLKI DVFARIPSIL LPSKTWQQEM 120
  121 GLQDEKLQTI FDKINSNQDI HLDSFHLPIN LSF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.0
Match:	1a25A_
Description:	C2 domain from protein kinase c (beta)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [306-338]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSAASIRLYN HHWITLDNGL GKINISIDYK PSR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [390-410]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 THTLAERTVL ARVDCPFIVP L

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [426-627]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FINGGELFYH LQKEGRFDLS RARFYTAELL CALDNLHKLD VVYRDLKPEN ILLDYQGHIA  60
   61 LCDFGLCKLN MKDDDKTDTF CGTPEYLAPE LLLGLGYTKA VDWWTLGVLL YEMLTGLPPY 120
  121 YDEDVPKMYK KILQEPLVFP DGFDRDAKDL LIGLLSRDPT RRLGYNGADE IRNHPFFSQL 180
  181 SWKRLLMKGY IPPYKPAVSN SM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	890.0
Match:	1atpE_
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [339-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPLSIDDFD LLKVIGKGSF GKVMQVRKKD TQKVYALKAI RKSYIVSKSE V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [411-425]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFSFQSPEKL YFVLA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [628-680]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTSNFDEEFT REKPIDSVVD EYLSESVQKQ FGGWTYVGNE QLGSSMVQGR SIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	890.0
Match:	1atpE_
Description:	cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: