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View Structure Prediction Details

Protein: KC13_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 524 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KC13_YEAST.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..516] [1..516]
gi|207345860 - gi|207345860|gb|EDZ72543.1| YER123Wp-like protein [Saccharomyces cerevisiae AWRI1631]
KC13_YEAST - Casein kinase I homolog 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YCK3 PE=1 SV=2
YCK3 - Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fus...
gi|151944838 - gi|151944838|gb|EDN63097.1| dasein kinase [Saccharomyces cerevisiae YJM789]
 0.0 [1..516] [1..516]
gi|14532894, gi|... - gi|8843885|dbj|BAA97411.1| casein kinase I [Arabidopsis thaliana], gi|62997000|gb|AAY24544.1| casein...
 0.0 [6..509] [1..452]
gi|13122442 - gi|13122442|dbj|BAB32922.1| casein kinase1 epsilon-2 [Rattus norvegicus]
 0.0 [6..492] [1..451]
KC1D_MOUSE - Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2
gi|117616262 - gi|117616262|gb|ABK42149.1| casein kinase I delta [synthetic construct]
KC1D_RAT - Casein kinase I isoform delta OS=Rattus norvegicus GN=Csnk1d PE=1 SV=2
 0.0 [6..450] [1..407]
CSNK1D - casein kinase 1, delta
gi|114671108 - gi|114671108|ref|XP_001167815.1| PREDICTED: casein kinase 1, delta isoform 3 [Pan troglodytes]
ENSCJAT00000035175 - null
KC1D_BOVIN - Casein kinase I isoform delta OS=Bos taurus GN=CSNK1D PE=2 SV=2
 0.0 [6..450] [1..407]

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Predicted Domain #1
Region A:
Residues: [1-73] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQRSSQHIV GIHYAVGPKI GEGSFGVIFE GENILHSCQA QTGSKRDSSI IMANEPVAIK  60
   61 FEPRHSDAPQ LRD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [90-105] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYYFGQEGMH NILIID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1185.045757
Match: 1csn__
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.47162554695064 bayes_pls_golite062009
peptidase activity 1.4194137915074 bayes_pls_golite062009
transcription regulator activity 1.30988141770642 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
DNA binding 1.17130513163489 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
cytoskeletal protein binding 1.1208666000428 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.02752755983942 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
hydrolase activity 0.950393847838778 bayes_pls_golite062009
transcription factor activity 0.919430701010326 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
tubulin binding 0.488928950975855 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
actin binding 0.464111806616899 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
telethonin binding 0.366817170817532 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
MAP kinase activity 0.26024936404169 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
microtubule binding 0.196718452862042 bayes_pls_golite062009
protein kinase C activity 0.0795689006739899 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [74-89] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFRAYRILNG CVGIPH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [106-111] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLGPSL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [136-204] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRVRAIHDHD LIYRDIKPDN FLISQYQRIS PEGKVIKSCA SSSNNDPNLI YMVDFGMAKQ  60
   61 YRDPRTKQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1185.045757
Match: 1csn__
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [112-135] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDLFEWCGRK FSVKTTCMVA KQMI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [205-392] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPYRERKSLS GTARYMSINT HFGREQSRRD DLESLGHVFF YFLRGSLPWQ GLKAPNNKLK  60
   61 YEKIGMTKQK LNPDDLLLNN AIPYQFATYL KYARSLKFDE DPDYDYLISL MDDALRLNDL 120
  121 KDDGHYDWMD LNGGKGWNIK INRRANLHGY GNPNPRVNGN TARNNVNTNS KTRNTTPVAT 180
  181 PKQQAQNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1185.045757
Match: 1csn__
Description: Casein kinase-1, CK1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [393-524] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNKDNSKSRI SSNPQSFTKQ QHVLKKIEPN SKYIPETHSN LQRPIKSQSQ TYDSISHTQN  60
   61 SPFVPYSSSK ANPKRSNNEH NLPNHYTNLA NKNINYQSQR NYEQENDAYS DDENDTFCSK 120
  121 IYKYCCCCFC CC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle