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View Structure Prediction Details

Protein: cyp-31A2
Organism: Caenorhabditis elegans
Length: 495 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyp-31A2.

Description E-value Query
Range		 Subject
Range
gi|115496944, gi... - gi|94574282|gb|AAI16042.1| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi|1...
 391.0 [0..23] [488..20]

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Predicted Domain #1
Region A:
Residues: [1-495] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVIIPAVLL AMATVIAWLL YKHLRMRQVL KHLNQPRSYP IVGHGLITKP DPEGFMNQVI  60
   61 GMGYLYPDPR MCLLWIGPFP CLMLYSADLV EPIFSSTKHL NKGFAYVLLE PWLGISILTS 120
  121 QKEQWRPKRK LLTPTFHYDI LKDFLPIFNE QSKILVQKLC CLGADEEVDV LSVITLCTLD 180
  181 IICETSMGKA IGAQLAENNE YVWAVHTINK LISKRTNNPL MWNSFIYNLT EDGRTHEKCL 240
  241 RILHDFTKKV IVERKEALQE NDYKMEGRLA FLDLLLEMVK SGQMDETDVQ AEVDTFMFEG 300
  301 HDTTSTGLMW AIHLLGNHPE VQRKVQAELD EVMGDDEDVT IEHLSRMKYL ECALKEALRL 360
  361 FPSVPIITRE LSDDQVIGGV NIPKGVTFLL NLYLVHRDPA QWKDPDVFDP DRFLPENSIG 420
  421 RKSFAFIPFS AGSRNCIGQR FALMEEKVIM AHLLRNFNIK AVELMHEVRP KMEIIVRPVT 480
  481 PIHMKLTRRR PIVSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.522879
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
monooxygenase activity 4.68917162030329 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
steroid hydroxylase activity 3.34643016685712 bayes_pls_golite062009
fluorene oxygenase activity 3.16634614522939 bayes_pls_golite062009
oxygen binding 2.77495508953933 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 2.0071742914584 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
retinoic acid binding 1.55035199545719 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.48367577297695 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 1.13877300596184 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
demethylase activity 1.0502020132476 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 0.89030345144459 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 0.89030345144459 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.56337818662492 bayes_pls_golite062009
iron ion binding 0.529598228513719 bayes_pls_golite062009
cation binding 0.510556740388808 bayes_pls_golite062009
metal ion binding 0.510556740388808 bayes_pls_golite062009
sterol 14-demethylase activity 0.510328098559181 bayes_pls_golite062009
ion binding 0.503326724714616 bayes_pls_golite062009
transition metal ion binding 0.450436868179747 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.203772707673481 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.100883462305119 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle