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View Protein Complex Details

Complex Overview

From Publication: Qiu J, Noble WS (2008) Predicting Co-Complexed Protein Pairs from Heterogeneous Data. PLoS Comput Biol 4(4): e1000054. doi:10.1371/journal.pcbi.1000054
Notes: Classifier used Gene Ontology annotations. [FDR: 0.02] [SVM Score: 1.20687229914]
Complex Size: 2 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
SIN3
  • Sin3 complex
  • histone deacetylase complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
    		•
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
    		•
    STB2
  • nucleus
  • Sin3 complex
    		•
  • histone deacetylation
    		•
  • transcription repressor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    Sin3 complex 3.0316E-7 2 4 2 6292
    Sin3-type complex 5.0527E-7 2 5 2 6292
    histone deacetylase complex 1.2783E-5 2 23 2 6292
    nuclear chromatin 1.3278E-4 2 73 2 6292
    chromatin 1.4784E-4 2 77 2 6292
    chromatin remodeling complex 2.4511E-4 2 99 2 6292
    nuclear chromosome part 9.0721E-4 2 190 2 6292
    nuclear chromosome 1.3075E-3 2 228 2 6292
    chromosomal part 1.413E-3 2 237 2 6292
    nucleoplasm part 1.5102E-3 2 245 2 6292
    nucleoplasm 1.7541E-3 2 264 2 6292
    chromosome 1.8898E-3 2 274 2 6292
    nuclear lumen 5.1728E-3 2 453 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone deacetylation 1.7735E-5 2 27 2 6292
    protein amino acid deacetylation 2.0514E-5 2 29 2 6292
    covalent chromatin modification 1.9342E-4 2 88 2 6292
    histone modification 1.9342E-4 2 88 2 6292
    chromatin modification 7.0879E-4 2 168 2 6292
    chromatin organization 1.036E-3 2 203 2 6292
    post-translational protein modification 3.2108E-3 2 357 2 6292
    chromatin silencing at rDNA 5.7138E-3 2 18 1 6292
    protein modification process 6.278E-3 2 499 2 6292
    chromosome organization 7.7677E-3 2 555 2 6292
    double-strand break repair via nonhomologous end joining 7.9314E-3 2 25 1 6292
    macromolecule modification 8.1649E-3 2 569 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription repressor activity 4.7798E-5 2 44 2 6292
    transcription regulator activity 2.8947E-3 2 339 2 6292
    transcription corepressor activity 5.0798E-3 2 16 1 6292
    transcription coactivator activity 6.6645E-3 2 21 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle