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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Arp2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARC15
  • mitochondrial envelope
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin cortical patch assembly
  • actin binding
  • structural molecule activity
  • ARC18
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • structural constituent of cytoskeleton
  • ARC19
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin cortical patch assembly
  • structural molecule activity
  • ARC35
  • cytosol
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • microtubule cytoskeleton organization
  • actin cytoskeleton organization
  • structural molecule activity
  • ARC40
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin nucleation
  • actin filament organization
  • structural constituent of cytoskeleton
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • ARP3
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • FET3
  • plasma membrane
  • high-affinity iron ion transport
  • response to copper ion
  • iron ion transmembrane transporter activity
  • ferroxidase activity
  • GFA1
  • cellular_component
  • cell wall chitin biosynthetic process
  • glutamine-fructose-6-phosphate transaminase (isomerizing) activity
  • PST2
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • PUF3
  • cytoplasm
  • external side of mitochondrial outer membrane
  • mRNA catabolic process
  • aerobic respiration
  • mitochondrion localization
  • mitochondrion organization
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Arp2/3 protein complex 4.4454E-20 14 7 7 6292
    actin cytoskeleton 2.0327E-10 14 85 7 6292
    cytoskeletal part 8.6859E-8 14 201 7 6292
    cytoskeleton 1.4267E-7 14 216 7 6292
    protein complex 1.7681E-5 14 1137 10 6292
    non-membrane-bounded organelle 3.6012E-4 14 959 8 6292
    intracellular non-membrane-bounded organelle 3.6012E-4 14 959 8 6292
    macromolecular complex 4.733E-4 14 1635 10 6292
    external side of mitochondrial outer membrane 2.225E-3 14 1 1 6292
    mitochondrial proton-transporting ATP synthase, central stalk 6.6614E-3 14 3 1 6292
    proton-transporting ATP synthase, central stalk 6.6614E-3 14 3 1 6292
    intracellular organelle part 7.9969E-3 14 2282 10 6292
    organelle part 7.9969E-3 14 2282 10 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrion localization 2.8441E-16 14 30 8 6292
    mitochondrion distribution 6.7908E-14 14 29 7 6292
    mitochondrion inheritance 6.7908E-14 14 29 7 6292
    organelle inheritance 1.643E-12 14 44 7 6292
    organelle localization 2.2311E-12 14 85 8 6292
    mitochondrion organization 3.1611E-10 14 156 8 6292
    actin cytoskeleton organization 1.5472E-9 14 113 7 6292
    actin filament-based process 1.979E-9 14 117 7 6292
    cytoskeleton organization 2.2631E-7 14 231 7 6292
    localization 9.2162E-6 14 1060 10 6292
    actin filament organization 1.1515E-5 14 68 4 6292
    cellular localization 1.9559E-5 14 643 8 6292
    organelle organization 1.5517E-4 14 1127 9 6292
    actin cortical patch assembly 4.1207E-4 14 14 2 6292
    cortical actin cytoskeleton organization 4.7486E-4 14 15 2 6292
    cortical cytoskeleton organization 4.7486E-4 14 15 2 6292
    ion transmembrane transport 2.1952E-3 14 32 2 6292
    cellular component organization 2.2238E-3 14 1582 9 6292
    actin nucleation 6.6614E-3 14 3 1 6292
    high-affinity iron ion transport 8.8726E-3 14 4 1 6292
    response to copper ion 8.8726E-3 14 4 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural molecule activity 3.0635E-6 14 339 7 6292
    structural constituent of cytoskeleton 4.2206E-6 14 53 4 6292
    actin binding 1.1394E-5 14 21 3 6292
    cytoskeletal protein binding 2.6493E-4 14 59 3 6292
    ATP binding 1.234E-3 14 24 2 6292
    adenyl ribonucleotide binding 1.3396E-3 14 25 2 6292
    adenyl nucleotide binding 1.9301E-3 14 30 2 6292
    purine nucleoside binding 2.0606E-3 14 31 2 6292
    nucleoside binding 2.1952E-3 14 32 2 6292
    glutamine-fructose-6-phosphate transaminase (isomerizing) activity 2.225E-3 14 1 1 6292
    ribonucleotide binding 3.5879E-3 14 41 2 6292
    purine ribonucleotide binding 3.5879E-3 14 41 2 6292
    oxidoreductase activity, oxidizing metal ions, oxygen as acceptor 4.4455E-3 14 2 1 6292
    ferroxidase activity 4.4455E-3 14 2 1 6292
    purine nucleotide binding 5.7214E-3 14 52 2 6292
    nucleotide binding 7.3172E-3 14 59 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle