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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Kss1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AVO1
  • TORC2 complex
  • cytoplasm
  • fungal-type cell wall organization
  • negative regulation of Ras protein signal transduction
  • regulation of cell growth
  • establishment or maintenance of actin cytoskeleton polarity
  • Ras GTPase binding
  • BEM3
  • intracellular
  • budding cell isotropic bud growth
  • small GTPase mediated signal transduction
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • budding cell apical bud growth
  • Rho GTPase activator activity
  • phosphatidylinositol-3-phosphate binding
  • signal transducer activity
  • CCT2
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • DIG1
  • nucleus
  • telomere maintenance
  • invasive growth in response to glucose limitation
  • DNA binding
  • transcription factor binding
  • DIG2
  • nucleus
  • invasive growth in response to glucose limitation
  • transcription factor binding
  • GUS1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • glutamyl-tRNA aminoacylation
  • glutamate-tRNA ligase activity
  • KSS1
  • nucleus
  • invasive growth in response to glucose limitation
  • signal transduction during filamentous growth
  • MAP kinase activity
  • NPA3
  • cytoplasm
  • biological_process
  • ATPase activity
  • PIM1
  • mitochondrial matrix
  • mitochondrion
  • response to heat
  • proteolysis
  • ATP-dependent peptidase activity
  • RPA135
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RVB1
  • nucleus
  • Swr1 complex
  • Ino80 complex
  • chromatin remodeling complex
  • chromatin remodeling
  • regulation of transcription from RNA polymerase II promoter
  • ATPase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • STE11
  • cytoplasm
  • activation of MAPKK activity
  • MAPKKK cascade involved in osmosensory signaling pathway
  • pseudohyphal growth
  • osmosensory signaling pathway via Sho1 osmosensor
  • invasive growth in response to glucose limitation
  • signal transduction during filamentous growth
  • protein amino acid phosphorylation
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • SAM domain binding
  • MAP kinase kinase kinase activity
  • STE12
  • nucleus
  • positive regulation of transcription from RNA polymerase II promoter by pheromones
  • conjugation with cellular fusion
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • transcription factor activity
  • TEC1
  • nucleus
  • pseudohyphal growth
  • invasive growth in response to glucose limitation
  • positive regulation of transcription from RNA polymerase II promoter
  • specific RNA polymerase II transcription factor activity
  • TSC11
  • TORC2 complex
  • regulation of cell growth
  • cellular cell wall organization
  • establishment or maintenance of actin cytoskeleton polarity
  • sphingolipid biosynthetic process
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    TORC2 complex 2.4464E-4 17 9 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    invasive growth in response to glucose limitation 1.4982E-11 17 47 7 6292
    growth 2.9727E-11 17 145 9 6292
    filamentous growth of a population of unicellular organisms 1.6756E-9 17 90 7 6292
    growth of unicellular organism as a thread of attached cells 1.6756E-9 17 90 7 6292
    filamentous growth 5.3437E-9 17 106 7 6292
    cell growth 4.838E-8 17 83 6 6292
    regulation of cell size 2.7817E-7 17 111 6 6292
    regulation of cellular component size 3.2615E-7 17 114 6 6292
    regulation of anatomical structure size 3.2615E-7 17 114 6 6292
    pseudohyphal growth 2.6716E-5 17 68 4 6292
    signal transduction during filamentous growth 1.9058E-4 17 8 2 6292
    establishment or maintenance of actin cytoskeleton polarity 2.4464E-4 17 9 2 6292
    establishment or maintenance of cytoskeleton polarity 2.4464E-4 17 9 2 6292
    regulation of biological quality 3.3896E-4 17 551 7 6292
    regulation of cell growth 4.4637E-4 17 12 2 6292
    regulation of cellular process 5.3754E-4 17 796 8 6292
    regulation of growth 6.135E-4 17 14 2 6292
    regulation of biological process 6.8209E-4 17 824 8 6292
    biological regulation 1.9436E-3 17 1213 9 6292
    signal transduction 2.1843E-3 17 214 4 6292
    signal transmission 2.2987E-3 17 217 4 6292
    signaling process 2.2987E-3 17 217 4 6292
    intracellular signal transduction 3.355E-3 17 115 3 6292
    signaling 3.9576E-3 17 252 4 6292
    cysteine biosynthetic process 5.3968E-3 17 2 1 6292
    intracellular signaling pathway 6.3085E-3 17 144 3 6292
    osmosensory signaling pathway via Sho1 osmosensor 8.0849E-3 17 3 1 6292
    glutamyl-tRNA aminoacylation 8.0849E-3 17 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    molecular transducer activity 1.1837E-3 17 80 3 6292
    signal transducer activity 1.1837E-3 17 80 3 6292
    cystathionine beta-synthase activity 2.7018E-3 17 1 1 6292
    protein binding 4.0054E-3 17 612 6 6292
    receptor signaling protein serine/threonine kinase activity 4.1015E-3 17 36 2 6292
    receptor signaling protein activity 4.329E-3 17 37 2 6292
    ATP-dependent peptidase activity 5.3968E-3 17 2 1 6292
    transcription factor binding 5.8138E-3 17 43 2 6292
    SAM domain binding 8.0849E-3 17 3 1 6292
    glutamate-tRNA ligase activity 8.0849E-3 17 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle