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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 7 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ASF1
  • chromatin assembly complex
  • histone acetylation
  • DNA replication-independent nucleosome assembly
  • chromatin silencing at silent mating-type cassette
  • nucleosome disassembly
  • chromatin silencing at telomere
  • DNA replication-dependent nucleosome assembly
  • histone binding
  • HIR1
  • nucleus
  • HIR complex
  • chromosome, centromeric region
  • DNA replication-independent nucleosome assembly
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription corepressor activity
  • HIR2
  • nucleus
  • HIR complex
  • DNA replication-independent nucleosome assembly
  • regulation of transcription from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription corepressor activity
  • HIR3
  • nucleus
  • HIR complex
  • regulation of transcription involved in G1/S-phase of mitotic cell cycle
  • DNA replication-independent nucleosome assembly
  • RNA elongation from RNA polymerase II promoter
  • transcription corepressor activity
  • HPC2
  • nucleus
  • HIR complex
  • regulation of transcription involved in G1/S-phase of mitotic cell cycle
  • DNA replication-independent nucleosome assembly
  • RNA elongation from RNA polymerase II promoter
  • transcription regulator activity
  • QDR2
  • integral to plasma membrane
  • drug transmembrane transport
  • potassium ion import
  • substrate-specific transmembrane transporter activity
  • drug transmembrane transporter activity
  • transporter activity
  • SFP1
  • nucleus
  • cytoplasm
  • transcription from RNA polymerase III promoter
  • regulation of cell size
  • ribosome biogenesis
  • transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin assembly complex 2.0233E-13 7 12 5 6292
    HIR complex 2.6813E-12 7 5 4 6292
    nuclear part 2.5214E-3 7 1103 5 6292
    protein complex 2.9048E-3 7 1137 5 6292
    nucleus 5.8629E-3 7 2041 6 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication-independent nucleosome assembly 1.5353E-15 7 6 5 6292
    DNA replication-independent nucleosome organization 1.5353E-15 7 6 5 6292
    nucleosome assembly 1.1147E-12 7 16 5 6292
    chromatin assembly 2.9651E-12 7 19 5 6292
    nucleosome organization 3.0202E-11 7 29 5 6292
    DNA packaging 5.1173E-11 7 32 5 6292
    chromatin assembly or disassembly 8.2429E-11 7 35 5 6292
    protein-DNA complex assembly 1.4604E-10 7 39 5 6292
    DNA conformation change 1.1564E-9 7 58 5 6292
    RNA elongation from RNA polymerase II promoter 4.3538E-8 7 39 4 6292
    RNA elongation 7.8686E-8 7 45 4 6292
    cellular macromolecular complex assembly 3.8428E-7 7 182 5 6292
    chromatin organization 6.6344E-7 7 203 5 6292
    transcription, DNA-dependent 1.657E-6 7 503 6 6292
    RNA biosynthetic process 1.7576E-6 7 508 6 6292
    cellular macromolecular complex subunit organization 2.2329E-6 7 259 5 6292
    transcription 2.8813E-6 7 552 6 6292
    macromolecular complex assembly 3.3466E-6 7 281 5 6292
    macromolecular complex subunit organization 1.093E-5 7 357 5 6292
    regulation of transcription, DNA-dependent 1.1082E-5 7 358 5 6292
    cellular component biogenesis 1.1204E-5 7 694 6 6292
    regulation of RNA metabolic process 1.1866E-5 7 363 5 6292
    regulation of transcription 1.5651E-5 7 384 5 6292
    cellular component assembly 1.5852E-5 7 385 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.292E-5 7 415 5 6292
    regulation of nitrogen compound metabolic process 2.3192E-5 7 416 5 6292
    regulation of gene expression 3.2272E-5 7 445 5 6292
    regulation of macromolecule biosynthetic process 3.637E-5 7 456 5 6292
    regulation of cellular biosynthetic process 4.3052E-5 7 472 5 6292
    regulation of biosynthetic process 4.35E-5 7 473 5 6292
    regulation of macromolecule metabolic process 5.0667E-5 7 488 5 6292
    regulation of transcription from RNA polymerase II promoter 5.3945E-5 7 228 4 6292
    regulation of primary metabolic process 6.5267E-5 7 514 5 6292
    RNA metabolic process 7.3069E-5 7 954 6 6292
    regulation of cellular metabolic process 8.0046E-5 7 536 5 6292
    regulation of metabolic process 8.836E-5 7 547 5 6292
    chromosome organization 9.4822E-5 7 555 5 6292
    regulation of transcription involved in G1/S-phase of mitotic cell cycle 9.5944E-5 7 14 2 6292
    transcription from RNA polymerase II promoter 2.4308E-4 7 335 4 6292
    cellular macromolecule biosynthetic process 2.6203E-4 7 1187 6 6292
    macromolecule biosynthetic process 2.6461E-4 7 1189 6 6292
    biological regulation 2.9723E-4 7 1213 6 6292
    gene expression 4.1171E-4 7 1283 6 6292
    regulation of cellular process 5.3954E-4 7 796 5 6292
    regulation of biological process 6.3633E-4 7 824 5 6292
    nucleic acid metabolic process 7.2556E-4 7 1415 6 6292
    nucleosome disassembly 1.1125E-3 7 1 1 6292
    DNA replication-dependent nucleosome assembly 1.1125E-3 7 1 1 6292
    DNA replication-dependent nucleosome organization 1.1125E-3 7 1 1 6292
    potassium ion import 1.1125E-3 7 1 1 6292
    chromatin disassembly 1.1125E-3 7 1 1 6292
    protein-DNA complex disassembly 1.1125E-3 7 1 1 6292
    G1/S transition of mitotic cell cycle 1.2671E-3 7 50 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3005E-3 7 1566 6 6292
    cellular biosynthetic process 1.3053E-3 7 1567 6 6292
    biosynthetic process 1.4816E-3 7 1602 6 6292
    cellular nitrogen compound metabolic process 2.6186E-3 7 1770 6 6292
    organelle organization 2.7877E-3 7 1127 5 6292
    nitrogen compound metabolic process 2.8003E-3 7 1791 6 6292
    potassium ion transport 4.4437E-3 7 4 1 6292
    interphase of mitotic cell cycle 4.6971E-3 7 97 2 6292
    interphase 4.6971E-3 7 97 2 6292
    drug transmembrane transport 8.8705E-3 7 8 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription corepressor activity 4.6941E-7 7 16 3 6292
    transcription cofactor activity 8.1872E-6 7 40 3 6292
    transcription regulator activity 8.4682E-6 7 339 5 6292
    transcription factor binding 1.0212E-5 7 43 3 6292
    transcription repressor activity 1.0954E-5 7 44 3 6292
    protein binding 2.4409E-3 7 612 4 6292
    binding 5.2851E-3 7 1294 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle