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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 5 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APC1
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC2
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC4
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC5
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • chromatin assembly or disassembly
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC23
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    anaphase-promoting complex 1.4172E-13 5 19 5 6292
    nuclear ubiquitin ligase complex 4.1011E-13 5 23 5 6292
    ubiquitin ligase complex 1.1732E-11 5 43 5 6292
    nuclear part 1.6432E-4 5 1103 5 6292
    protein complex 1.913E-4 5 1137 5 6292
    macromolecular complex 1.1794E-3 5 1635 5 6292
    nucleus 3.5796E-3 5 2041 5 6292
    organelle part 6.2578E-3 5 2282 5 6292
    intracellular organelle part 6.2578E-3 5 2282 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cyclin catabolic process 1.5686E-14 5 13 5 6292
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 5.3237E-14 5 16 5 6292
    mitotic spindle elongation 2.4801E-13 5 21 5 6292
    spindle elongation 2.4801E-13 5 21 5 6292
    mitotic metaphase/anaphase transition 5.3127E-12 5 37 5 6292
    mitotic spindle organization 2.0869E-11 5 48 5 6292
    spindle organization 2.3241E-11 5 49 5 6292
    protein ubiquitination 1.0067E-10 5 65 5 6292
    mitotic sister chromatid segregation 1.0892E-10 5 66 5 6292
    sister chromatid segregation 1.3697E-10 5 69 5 6292
    proteasomal protein catabolic process 1.3697E-10 5 69 5 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.3697E-10 5 69 5 6292
    protein modification by small protein conjugation 4.2446E-10 5 86 5 6292
    microtubule cytoskeleton organization 7.8546E-10 5 97 5 6292
    mitosis 1.1208E-9 5 104 5 6292
    nuclear division 1.2351E-9 5 106 5 6292
    microtubule-based process 1.5621E-9 5 111 5 6292
    organelle fission 1.7107E-9 5 113 5 6292
    protein modification by small protein conjugation or removal 1.7892E-9 5 114 5 6292
    chromosome segregation 3.2245E-9 5 128 5 6292
    M phase of mitotic cell cycle 3.2245E-9 5 128 5 6292
    modification-dependent protein catabolic process 8.7955E-9 5 156 5 6292
    ubiquitin-dependent protein catabolic process 8.7955E-9 5 156 5 6292
    proteolysis involved in cellular protein catabolic process 9.6863E-9 5 159 5 6292
    modification-dependent macromolecule catabolic process 1.133E-8 5 164 5 6292
    cellular protein catabolic process 1.3999E-8 5 171 5 6292
    proteolysis 2.2607E-8 5 188 5 6292
    protein catabolic process 2.3222E-8 5 189 5 6292
    cytoskeleton organization 6.3956E-8 5 231 5 6292
    mitotic cell cycle 1.0527E-7 5 255 5 6292
    cellular macromolecule catabolic process 1.2779E-7 5 265 5 6292
    macromolecule catabolic process 2.1559E-7 5 294 5 6292
    M phase 2.1559E-7 5 294 5 6292
    post-translational protein modification 5.7263E-7 5 357 5 6292
    cell cycle phase 7.4317E-7 5 376 5 6292
    cellular catabolic process 1.2203E-6 5 415 5 6292
    cell cycle process 2.8108E-6 5 490 5 6292
    catabolic process 2.9879E-6 5 496 5 6292
    protein modification process 3.0798E-6 5 499 5 6292
    cell cycle 3.9742E-6 5 525 5 6292
    chromosome organization 5.2525E-6 5 555 5 6292
    macromolecule modification 5.9519E-6 5 569 5 6292
    cellular protein metabolic process 1.4379E-4 5 1074 5 6292
    organelle organization 1.8302E-4 5 1127 5 6292
    protein metabolic process 1.9046E-4 5 1136 5 6292
    cellular component organization 1.0001E-3 5 1582 5 6292
    cellular macromolecule metabolic process 6.2991E-3 5 2285 5 6292
    macromolecule metabolic process 7.2329E-3 5 2349 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 5.1032E-11 5 57 5 6292
    small conjugating protein ligase activity 7.8868E-11 5 62 5 6292
    acid-amino acid ligase activity 1.5869E-10 5 71 5 6292
    ligase activity, forming carbon-nitrogen bonds 6.69E-10 5 94 5 6292
    ligase activity 7.2103E-9 5 150 5 6292
    protein binding 8.5781E-6 5 612 5 6292
    binding 3.6564E-4 5 1294 5 6292
    catalytic activity 4.6443E-3 5 2150 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle