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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 6 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APC1
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC2
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC4
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC16
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC23
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC27
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    anaphase-promoting complex 3.1559E-16 6 19 6 6292
    nuclear ubiquitin ligase complex 1.1742E-15 6 23 6 6292
    ubiquitin ligase complex 7.0911E-14 6 43 6 6292
    nuclear part 2.8697E-5 6 1103 6 6292
    protein complex 3.4445E-5 6 1137 6 6292
    macromolecular complex 3.0579E-4 6 1635 6 6292
    nucleus 1.1592E-3 6 2041 6 6292
    organelle part 2.2664E-3 6 2282 6 6292
    intracellular organelle part 2.2664E-3 6 2282 6 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cyclin catabolic process 1.996E-17 6 13 6 6292
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 9.3145E-17 6 16 6 6292
    mitotic spindle elongation 6.3117E-16 6 21 6 6292
    spindle elongation 6.3117E-16 6 21 6 6292
    mitotic metaphase/anaphase transition 2.7041E-14 6 37 6 6292
    mitotic spindle organization 1.4274E-13 6 48 6 6292
    spindle organization 1.6265E-13 6 49 6 6292
    protein ubiquitination 9.6075E-13 6 65 6 6292
    mitotic sister chromatid segregation 1.0568E-12 6 66 6 6292
    sister chromatid segregation 1.3944E-12 6 69 6 6292
    proteasomal protein catabolic process 1.3944E-12 6 69 6 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.3944E-12 6 69 6 6292
    protein modification by small protein conjugation 5.4686E-12 6 86 6 6292
    microtubule cytoskeleton organization 1.1494E-11 6 97 6 6292
    mitosis 1.7649E-11 6 104 6 6292
    nuclear division 1.9842E-11 6 106 6 6292
    microtubule-based process 2.6337E-11 6 111 6 6292
    organelle fission 2.9388E-11 6 113 6 6292
    protein modification by small protein conjugation or removal 3.102E-11 6 114 6 6292
    chromosome segregation 6.3085E-11 6 128 6 6292
    M phase of mitotic cell cycle 6.3085E-11 6 128 6 6292
    modification-dependent protein catabolic process 2.1125E-10 6 156 6 6292
    ubiquitin-dependent protein catabolic process 2.1125E-10 6 156 6 6292
    proteolysis involved in cellular protein catabolic process 2.3727E-10 6 159 6 6292
    modification-dependent macromolecule catabolic process 2.8654E-10 6 164 6 6292
    cellular protein catabolic process 3.6963E-10 6 171 6 6292
    proteolysis 6.5805E-10 6 188 6 6292
    protein catabolic process 6.7962E-10 6 189 6 6292
    cytoskeleton organization 2.299E-9 6 231 6 6292
    mitotic cell cycle 4.1861E-9 6 255 6 6292
    cellular macromolecule catabolic process 5.2847E-9 6 265 6 6292
    macromolecule catabolic process 9.9104E-9 6 294 6 6292
    M phase 9.9104E-9 6 294 6 6292
    post-translational protein modification 3.2061E-8 6 357 6 6292
    cell cycle phase 4.3855E-8 6 376 6 6292
    cellular catabolic process 7.9584E-8 6 415 6 6292
    cell cycle process 2.1684E-7 6 490 6 6292
    catabolic process 2.3335E-7 6 496 6 6292
    protein modification process 2.4199E-7 6 499 6 6292
    cell cycle 3.2871E-7 6 525 6 6292
    chromosome organization 4.595E-7 6 555 6 6292
    macromolecule modification 5.3394E-7 6 569 6 6292
    cellular protein metabolic process 2.4449E-5 6 1074 6 6292
    organelle organization 3.2663E-5 6 1127 6 6292
    protein metabolic process 3.4263E-5 6 1136 6 6292
    cellular component organization 2.5085E-4 6 1582 6 6292
    cellular macromolecule metabolic process 2.2844E-3 6 2285 6 6292
    macromolecule metabolic process 2.6967E-3 6 2349 6 6292
    primary metabolic process 9.4808E-3 6 2896 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 4.2209E-13 6 57 6 6292
    small conjugating protein ligase activity 7.1504E-13 6 62 6 6292
    acid-amino acid ligase activity 1.6659E-12 6 71 6 6292
    ligase activity, forming carbon-nitrogen bonds 9.4706E-12 6 94 6 6292
    ligase activity 1.663E-10 6 150 6 6292
    protein binding 8.282E-7 6 612 6 6292
    binding 7.4967E-5 6 1294 6 6292
    catalytic activity 1.5845E-3 6 2150 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle