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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DBP9
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • EBP2
  • nucleolus
  • nuclear division
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.3978E-27 18 211 18 6292
    nuclear lumen 1.9658E-21 18 453 18 6292
    organelle lumen 1.9168E-18 18 660 18 6292
    intracellular organelle lumen 1.9168E-18 18 660 18 6292
    membrane-enclosed lumen 5.6029E-18 18 700 18 6292
    non-membrane-bounded organelle 1.7195E-15 18 959 18 6292
    intracellular non-membrane-bounded organelle 1.7195E-15 18 959 18 6292
    nuclear part 2.1786E-14 18 1103 18 6292
    nucleus 1.5028E-9 18 2041 18 6292
    intracellular organelle part 1.1294E-8 18 2282 18 6292
    organelle part 1.1294E-8 18 2282 18 6292
    preribosome, large subunit precursor 1.6342E-6 18 9 3 6292
    Noc1p-Noc2p complex 7.7306E-6 18 2 2 6292
    Noc complex 7.6913E-5 18 5 2 6292
    nuclear outer membrane 8.6024E-5 18 86 4 6292
    membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    preribosome 1.1132E-4 18 34 3 6292
    nuclear membrane 1.3762E-4 18 97 4 6292
    intracellular organelle 3.879E-4 18 4070 18 6292
    organelle 3.8963E-4 18 4071 18 6292
    90S preribosome 1.0249E-3 18 17 2 6292
    outer membrane 1.3885E-3 18 178 4 6292
    organelle outer membrane 1.3885E-3 18 178 4 6292
    nuclear envelope 2.0962E-3 18 199 4 6292
    nuclear membrane-endoplasmic reticulum network 3.6646E-3 18 232 4 6292
    Noc2p-Noc3p complex 5.7138E-3 18 2 1 6292
    nucleolar part 7.1157E-3 18 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.3816E-23 18 346 18 6292
    ribonucleoprotein complex biogenesis 5.8017E-23 18 374 18 6292
    ribosomal large subunit biogenesis 8.9699E-21 18 65 12 6292
    cellular component biogenesis 4.7894E-18 18 694 18 6292
    ribosome assembly 2.3458E-10 18 64 7 6292
    organelle assembly 4.0428E-10 18 69 7 6292
    ribosomal large subunit assembly 9.1671E-10 18 41 6 6292
    ribonucleoprotein complex assembly 3.168E-9 18 92 7 6292
    ribosomal subunit assembly 5.7758E-9 18 55 6 6292
    cellular macromolecular complex assembly 3.671E-7 18 182 7 6292
    rRNA processing 9.578E-7 18 128 6 6292
    rRNA metabolic process 1.4299E-6 18 137 6 6292
    cellular macromolecular complex subunit organization 3.9815E-6 18 259 7 6292
    macromolecular complex assembly 6.8485E-6 18 281 7 6292
    ncRNA processing 1.9533E-5 18 215 6 6292
    macromolecular complex subunit organization 3.2951E-5 18 357 7 6292
    cellular component assembly 5.3684E-5 18 385 7 6292
    ncRNA metabolic process 5.3725E-5 18 257 6 6292
    RNA processing 4.6476E-4 18 380 6 6292
    cellular process 1.7601E-3 18 4426 18 6292
    establishment of ribosome localization 2.4123E-3 18 26 2 6292
    ribosome localization 2.4123E-3 18 26 2 6292
    ribosomal subunit export from nucleus 2.4123E-3 18 26 2 6292
    organelle organization 8.2746E-3 18 1127 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 6.1601E-5 18 28 3 6292
    RNA-dependent ATPase activity 6.8585E-5 18 29 3 6292
    RNA helicase activity 2.1052E-4 18 42 3 6292
    ATP-dependent helicase activity 3.1378E-4 18 48 3 6292
    purine NTP-dependent helicase activity 3.1378E-4 18 48 3 6292
    rRNA binding 9.059E-4 18 16 2 6292
    helicase activity 1.5656E-3 18 83 3 6292
    5S rRNA binding 5.7138E-3 18 2 1 6292
    ATPase activity, coupled 8.1798E-3 18 149 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle