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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
LSM1
  • mRNA cap binding complex
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • RNA binding
  • RNA cap binding
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM7
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • telomere maintenance
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PAT1
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • chromosome segregation
  • regulation of translational initiation
  • molecular_function
  • PRP24
  • U6 snRNP
  • spliceosome assembly
  • assembly of spliceosomal tri-snRNP
  • nucleic acid binding
  • nucleotide binding
  • U6 snRNA binding
  • RNA binding
  • snRNA binding
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 2.5398E-13 9 63 7 6292
    U6 snRNP 7.0723E-13 9 11 5 6292
    U4/U6 x U5 tri-snRNP complex 8.7601E-13 9 32 6 6292
    ribonucleoprotein complex 1.5187E-10 9 514 9 6292
    small nucleolar ribonucleoprotein complex 1.9024E-6 9 72 4 6292
    macromolecular complex 5.3146E-6 9 1635 9 6292
    nuclear part 1.2953E-4 9 1103 7 6292
    nucleolus 1.3568E-4 9 211 4 6292
    cytoplasmic mRNA processing body 1.8916E-4 9 15 2 6292
    nuclear lumen 2.4955E-3 9 453 4 6292
    mRNA cap binding complex 4.2857E-3 9 3 1 6292
    nucleus 6.9589E-3 9 2041 7 6292
    RNA cap binding complex 8.5551E-3 9 6 1 6292
    organelle lumen 9.8194E-3 9 660 4 6292
    intracellular organelle lumen 9.8194E-3 9 660 4 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA metabolic process 4.9477E-14 9 213 9 6292
    nuclear mRNA splicing, via spliceosome 6.7651E-12 9 99 7 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7.2722E-12 9 100 7 6292
    RNA splicing, via transesterification reactions 1.1823E-11 9 107 7 6292
    RNA splicing 5.3057E-11 9 132 7 6292
    mRNA catabolic process 1.1413E-10 9 69 6 6292
    mRNA processing 1.7402E-10 9 156 7 6292
    RNA catabolic process 2.848E-10 9 80 6 6292
    RNA metabolic process 4.101E-8 9 954 9 6292
    RNA processing 9.0007E-8 9 380 7 6292
    cellular macromolecule catabolic process 3.9855E-7 9 265 6 6292
    macromolecule catabolic process 7.3826E-7 9 294 6 6292
    nucleic acid metabolic process 1.4425E-6 9 1415 9 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.6017E-6 9 1566 9 6292
    cellular catabolic process 5.6289E-6 9 415 6 6292
    cellular nitrogen compound metabolic process 1.0872E-5 9 1770 9 6292
    nitrogen compound metabolic process 1.2092E-5 9 1791 9 6292
    catabolic process 1.5934E-5 9 496 6 6292
    gene expression 2.1668E-5 9 1283 8 6292
    deadenylation-dependent decapping of nuclear-transcribed mRNA 9.9377E-5 9 11 2 6292
    cellular macromolecule metabolic process 1.0877E-4 9 2285 9 6292
    macromolecule metabolic process 1.3953E-4 9 2349 9 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 6.2672E-4 9 27 2 6292
    primary metabolic process 9.2081E-4 9 2896 9 6292
    nuclear-transcribed mRNA catabolic process 1.245E-3 9 38 2 6292
    cellular metabolic process 1.3966E-3 9 3033 9 6292
    metabolic process 2.004E-3 9 3157 9 6292
    spliceosomal snRNP assembly 2.859E-3 9 2 1 6292
    assembly of spliceosomal tri-snRNP 2.859E-3 9 2 1 6292
    generation of catalytic spliceosome for first transesterification step 4.2857E-3 9 3 1 6292
    ribonucleoprotein complex assembly 7.1217E-3 9 92 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 7.0672E-8 9 367 7 6292
    nucleic acid binding 4.2982E-6 9 666 7 6292
    snRNA binding 1.8149E-5 9 5 2 6292
    binding 3.7284E-4 9 1294 7 6292
    U6 snRNA binding 1.4304E-3 9 1 1 6292
    RNA cap binding 2.859E-3 9 2 1 6292
    U5 snRNA binding 2.859E-3 9 2 1 6292
    nucleotide binding 2.9832E-3 9 59 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle