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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU23
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • zinc ion binding
  • metal ion binding
  • molecular_function
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U4/U6 x U5 tri-snRNP complex 2.1243E-39 16 32 16 6292
    small nuclear ribonucleoprotein complex 1.2949E-33 16 63 16 6292
    U5 snRNP 6.3289E-19 16 14 8 6292
    ribonucleoprotein complex 3.167E-18 16 514 16 6292
    nuclear part 7.2679E-13 16 1103 16 6292
    macromolecular complex 4.0924E-10 16 1635 16 6292
    nucleus 1.444E-8 16 2041 16 6292
    U1 snRNP 6.5086E-8 16 17 4 6292
    organelle part 8.6662E-8 16 2282 16 6292
    intracellular organelle part 8.6662E-8 16 2282 16 6292
    membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    U6 snRNP 3.2905E-4 16 11 2 6292
    commitment complex 3.9428E-4 16 12 2 6292
    U2-type spliceosomal complex 3.9428E-4 16 12 2 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    spliceosomal complex 5.6318E-3 16 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 3.9955E-30 16 99 16 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4.7565E-30 16 100 16 6292
    RNA splicing, via transesterification reactions 1.5324E-29 16 107 16 6292
    RNA splicing 5.5669E-28 16 132 16 6292
    mRNA processing 9.3744E-27 16 156 16 6292
    mRNA metabolic process 1.7018E-24 16 213 16 6292
    RNA processing 2.3182E-20 16 380 16 6292
    RNA metabolic process 7.0068E-14 16 954 16 6292
    gene expression 8.2892E-12 16 1283 16 6292
    nucleic acid metabolic process 4.0069E-11 16 1415 16 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0462E-10 16 1566 16 6292
    cellular nitrogen compound metabolic process 1.4646E-9 16 1770 16 6292
    nitrogen compound metabolic process 1.7702E-9 16 1791 16 6292
    cellular macromolecule metabolic process 8.851E-8 16 2285 16 6292
    macromolecule metabolic process 1.379E-7 16 2349 16 6292
    primary metabolic process 3.9666E-6 16 2896 16 6292
    cellular metabolic process 8.3256E-6 16 3033 16 6292
    metabolic process 1.5832E-5 16 3157 16 6292
    spliceosomal conformational changes to generate catalytic conformation 2.1602E-4 16 9 2 6292
    ribonucleoprotein complex assembly 1.476E-3 16 92 3 6292
    regulation of hormone levels 2.5429E-3 16 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.5429E-3 16 1 1 6292
    auxin biosynthetic process 2.5429E-3 16 1 1 6292
    auxin metabolic process 2.5429E-3 16 1 1 6292
    hormone metabolic process 2.5429E-3 16 1 1 6292
    hormone biosynthetic process 2.5429E-3 16 1 1 6292
    cellular process 3.565E-3 16 4426 16 6292
    nuclear mRNA 3'-splice site recognition 5.0798E-3 16 2 1 6292
    generation of catalytic spliceosome for first transesterification step 7.6106E-3 16 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 2.3636E-9 16 367 10 6292
    nucleic acid binding 7.3215E-7 16 666 10 6292
    binding 4.3472E-6 16 1294 12 6292
    U5 snRNA binding 6.0632E-6 16 2 2 6292
    snRNA binding 6.0363E-5 16 5 2 6292
    mRNA binding 3.4353E-3 16 35 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle