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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PAT1
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • chromosome segregation
  • regulation of translational initiation
  • molecular_function
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U4/U6 x U5 tri-snRNP complex 4.0926E-33 15 32 14 6292
    small nuclear ribonucleoprotein complex 3.2307E-28 15 63 14 6292
    ribonucleoprotein complex 3.9839E-17 15 514 15 6292
    U5 snRNP 1.7311E-13 15 14 6 6292
    nuclear part 3.0389E-10 15 1103 14 6292
    macromolecular complex 1.5857E-9 15 1635 15 6292
    nucleus 1.4521E-6 15 2041 14 6292
    U6 snRNP 1.7886E-6 15 11 3 6292
    organelle part 6.6039E-6 15 2282 14 6292
    intracellular organelle part 6.6039E-6 15 2282 14 6292
    small nucleolar ribonucleoprotein complex 5.9236E-4 15 72 3 6292
    U1 snRNP 7.0676E-4 15 17 2 6292
    membrane-bounded organelle 5.0597E-3 15 3771 14 6292
    intracellular membrane-bounded organelle 5.0597E-3 15 3771 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 3.266E-25 15 99 14 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3.7971E-25 15 100 14 6292
    RNA splicing, via transesterification reactions 1.044E-24 15 107 14 6292
    RNA splicing 2.3416E-23 15 132 14 6292
    mRNA metabolic process 5.3951E-23 15 213 15 6292
    mRNA processing 2.7092E-22 15 156 14 6292
    RNA processing 9.6995E-17 15 380 14 6292
    RNA metabolic process 4.6839E-13 15 954 15 6292
    gene expression 4.1034E-11 15 1283 15 6292
    nucleic acid metabolic process 1.7965E-10 15 1415 15 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.2811E-10 15 1566 15 6292
    cellular nitrogen compound metabolic process 5.2383E-9 15 1770 15 6292
    nitrogen compound metabolic process 6.2564E-9 15 1791 15 6292
    cellular macromolecule metabolic process 2.4475E-7 15 2285 15 6292
    macromolecule metabolic process 3.7086E-7 15 2349 15 6292
    primary metabolic process 8.6423E-6 15 2896 15 6292
    mRNA catabolic process 1.651E-5 15 69 4 6292
    cellular metabolic process 1.7316E-5 15 3033 15 6292
    RNA catabolic process 2.974E-5 15 80 4 6292
    metabolic process 3.1628E-5 15 3157 15 6292
    spliceosomal conformational changes to generate catalytic conformation 1.8916E-4 15 9 2 6292
    ribonucleoprotein complex assembly 1.212E-3 15 92 3 6292
    regulation of hormone levels 2.384E-3 15 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.384E-3 15 1 1 6292
    auxin biosynthetic process 2.384E-3 15 1 1 6292
    auxin metabolic process 2.384E-3 15 1 1 6292
    hormone metabolic process 2.384E-3 15 1 1 6292
    hormone biosynthetic process 2.384E-3 15 1 1 6292
    cellular macromolecule catabolic process 2.9058E-3 15 265 4 6292
    macromolecule catabolic process 4.2332E-3 15 294 4 6292
    nuclear mRNA 3'-splice site recognition 4.7627E-3 15 2 1 6292
    cellular process 5.0732E-3 15 4426 15 6292
    generation of catalytic spliceosome for first transesterification step 7.136E-3 15 3 1 6292
    cellular macromolecular complex assembly 8.3804E-3 15 182 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 2.5991E-8 15 367 9 6292
    nucleic acid binding 4.4011E-6 15 666 9 6292
    U5 snRNA binding 5.3053E-6 15 2 2 6292
    snRNA binding 5.2834E-5 15 5 2 6292
    binding 1.4204E-4 15 1294 10 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle