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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • URB1
  • nucleolus
  • rRNA processing
  • processing of 27S pre-rRNA
  • molecular_function
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.4552E-24 16 211 16 6292
    nuclear lumen 4.0631E-19 16 453 16 6292
    organelle lumen 1.823E-16 16 660 16 6292
    intracellular organelle lumen 1.823E-16 16 660 16 6292
    membrane-enclosed lumen 4.7232E-16 16 700 16 6292
    non-membrane-bounded organelle 7.6231E-14 16 959 16 6292
    intracellular non-membrane-bounded organelle 7.6231E-14 16 959 16 6292
    nuclear part 7.2679E-13 16 1103 16 6292
    nucleus 1.444E-8 16 2041 16 6292
    intracellular organelle part 8.6662E-8 16 2282 16 6292
    organelle part 8.6662E-8 16 2282 16 6292
    preribosome, large subunit precursor 1.1231E-6 16 9 3 6292
    Noc1p-Noc2p complex 6.0632E-6 16 2 2 6292
    Noc complex 6.0363E-5 16 5 2 6292
    preribosome 7.6962E-5 16 34 3 6292
    membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    90S preribosome 8.0644E-4 16 17 2 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    nuclear outer membrane 1.2141E-3 16 86 3 6292
    nuclear envelope 1.3102E-3 16 199 4 6292
    nuclear membrane 1.7195E-3 16 97 3 6292
    Noc2p-Noc3p complex 5.0798E-3 16 2 1 6292
    nucleolar part 5.6318E-3 16 45 2 6292
    outer membrane 9.502E-3 16 178 3 6292
    organelle outer membrane 9.502E-3 16 178 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 5.0115E-21 16 346 16 6292
    ribonucleoprotein complex biogenesis 1.7877E-20 16 374 16 6292
    cellular component biogenesis 4.1092E-16 16 694 16 6292
    ribosomal large subunit biogenesis 8.1618E-15 16 65 9 6292
    ribosome assembly 6.4505E-9 16 64 6 6292
    organelle assembly 1.0243E-8 16 69 6 6292
    ribosomal large subunit assembly 3.7851E-8 16 41 5 6292
    ribonucleoprotein complex assembly 5.9032E-8 16 92 6 6292
    ribosomal subunit assembly 1.7214E-7 16 55 5 6292
    rRNA processing 4.2723E-7 16 128 6 6292
    rRNA metabolic process 6.3938E-7 16 137 6 6292
    cellular macromolecular complex assembly 3.3946E-6 16 182 6 6292
    processing of 27S pre-rRNA 7.4064E-6 16 16 3 6292
    ncRNA processing 8.925E-6 16 215 6 6292
    ncRNA metabolic process 2.4836E-5 16 257 6 6292
    cellular macromolecular complex subunit organization 2.5957E-5 16 259 6 6292
    macromolecular complex assembly 4.1235E-5 16 281 6 6292
    macromolecular complex subunit organization 1.5755E-4 16 357 6 6292
    RNA processing 2.2235E-4 16 380 6 6292
    cellular component assembly 2.3891E-4 16 385 6 6292
    obsolete_biological_process 4.227E-4 16 60 3 6292
    establishment of ribosome localization 1.9016E-3 16 26 2 6292
    ribosome localization 1.9016E-3 16 26 2 6292
    ribosomal subunit export from nucleus 1.9016E-3 16 26 2 6292
    cellular process 3.565E-3 16 4426 16 6292
    RNA metabolic process 5.8716E-3 16 954 7 6292
    establishment of organelle localization 8.3236E-3 16 55 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 4.2528E-5 16 28 3 6292
    RNA-dependent ATPase activity 4.7361E-5 16 29 3 6292
    RNA helicase activity 1.4582E-4 16 42 3 6292
    ATP-dependent helicase activity 2.1767E-4 16 48 3 6292
    purine NTP-dependent helicase activity 2.1767E-4 16 48 3 6292
    rRNA binding 7.1262E-4 16 16 2 6292
    helicase activity 1.0951E-3 16 83 3 6292
    RNA binding 1.6796E-3 16 367 5 6292
    ATPase activity, coupled 5.8113E-3 16 149 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle