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Protein Overview: KRE6

General Information:
Name(s) found: KRE6 / YPR159W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 720 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDALink to PubMed article]
    Golgi cis cisterna [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article]
    1,6-beta-glucan biosynthetic process [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: glucosidase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLRNLTETH NFSSTNLDTD GTGDDHDGAP LSSSPSFGQQ NDNSTNDNAG LTNPFMGSDE  60
   61 ESNARDGESL SSSVHYQPQG SDSSLLHDNS RLDLSQNKGV SDYKGYYSRN NSRAVSTAND 120
  121 NSFLQPPHRA IASSPSLNSN LSKNDILSPP EFDRYPLVGS RVTSMTQLNH HGRSPTSSPG 180
  181 NESSASFSSN PFLGEQDFSP FGGYPASSFP LMIDEKEEDD YLHNPDPEEE ARLDRRRFID 240
  241 DFKYMDKRSA SGLAGVLLLF LAAIFIFIVL PALTFTGAID HESNTEEVTY LTQYQYPQLS 300
  301 AIRTSLVDPD TPDTAKTREA MDGSKWELVF SDEFNAEGRT FYDGDDPYWT APDVHYDATK 360
  361 DLEWYSPDAS TTVNGTLQLR MDAFKNHGLY YRSGMLQSWN KVCFTQGALE ISANLPNYGR 420
  421 VSGLWPGLWT MGNLGRPGYL ASTQGVWPYS YESCDAGITP NQSSPDGISY LPGQKLSICT 480
  481 CDGEDHPNQG VGRGAPEIDV LEGETDTKIG VGIASQSLQI APFDIWYMPD YDFIEVYNFT 540
  541 TTTMNTYAGG PFQQAVSAVS TLNVTWYEFG EYGGYFQKYA IEYLNDDDNG YIRWFVGDTP 600
  601 TYTIHAKALH PDGNIGWRRI SKEPMSIILN LGISNNWAYI DWQYIFFPVV MSIDYVRIYQ 660
  661 PSNAISVTCD PSDYPTYDYI QSHLNAFQNA NLTTWEDAGY TFPKNILTGK CTSSKFKLSS 720
  721

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) KRE6 SKN1
    View Details Ho Y, et al. (2002) APM1 BUD14 CMP2 CNA1 CNB1 DOG1 EMP24 GIS4 HSP104 KEL1 KEL2 KGD1 KIN2 KRE33 KRE6 POP2 RPN1 RPN12 RPN5 RPN6 RPN8 RPN9 RPT1 RPT2 TEF4 TFC4 UBA1 UFD4 YBL104C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GPI14 KRE6 2 Hazbun TR, et al. (2003)
    View Screen ILM1 KRE6 2 Lockshon D, et al. (2006)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KRE6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..206] deduced N/A No confident structure predictions are available.
    2 View Details [207..277] Pfam 14.886057 Beta-glucan synthesis-associated protein (SKN1) No confident structure predictions are available.
    3 View Details [278..551] PSI-BLAST 14.09691 kappa-Carrageenase, catalytic
    4 View Details [552..720] PSI-BLAST 32.0 Bacillus 1-3,1-4-beta-glucanase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.82375683349763 bayes_pls_golite062009
  • protein binding
    		•  0.964880666937228 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.351620947205387 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.21069016920331 bayes_pls_golite062009
  • DNA binding
    		•  0.0547031308830381 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0124152418993231 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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