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Protein Overview: WTM1

General Information:
Name(s) found: WTM1 / YOR230W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: regulation of meiosis [IGILink to PubMed article]
    Molecular Function: transcription corepressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKKVWKSST PSTYEHISSL RPKFVSRVDN VLHQRKSLTF SNVVVPDKKN NTLTSSVIYS  60
   61 QGSDIYEIDF AVPLQEAASE PVKDYGDAFE GIENTSLSPK FVYQGETVSK MAYLDKTGET 120
  121 TLLSMSKNGS LAWFKEGIKV PIHIVQELMG PATSYASIHS LTRPGDLPEK DFSLAISDFG 180
  181 ISNDTETIVK SQSNGDEEDS ILKIIDNAGK PGEILRTVHV PGTTVTHTVR FFDNHIFASC 240
  241 SDDNILRFWD TRTSDKPIWV LGEPKNGKLT SFDCSQVSNN LFVTGFSTGI IKLWDARAAE 300
  301 AATTDLTYRQ NGEDPIQNEI ANFYHAGGDS VVDVQFSATS SSEFFTVGGT GNIYHWNTDY 360
  361 SLSKYNPDDT IAPPQDATEE SQTKSLRFLH KGGSRRSPKQ IGRRNTAAWH PVIENLVGTV 420
  421 DDDSLVSIYK PYTEESE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RNR2 WTM1
    View Details Krogan NJ, et al. (2006) GIN4 HFD1 HTZ1 KAP114 KCC4 NAP1 PRO3 REI1 RIM11 RPS6A, RPS6B UBC8 VIP1 WTM1 YKR011C
    View Details Gavin AC, et al. (2006) ARO3 WTM1
    View Details Ho Y, et al. (2002) AAT2 ACH1 ACO1 ACS2 AFR1 AHP1 ARC1 ARF1 ATP3 CAR2 CCT2 CCT3 CCT6 CDC33 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DLD3 DUG1 EGD1 ERG10 ERG13 ERG6 FPR1 FRS2 FUM1 GND1 GND2 GRX1 GUS1 HEF3 HHF1, HHF2 ILV3 LRO1 LSP1 MET6 NTF2 OLA1 OYE2 PFK1 PIL1 PRM2 RHO1 RNR2 RSN1 RVB1 SAH1 SCP160 SEC53 SEN15 SES1 SNU13 SOD1 TCP1 TEF4 THS1 TIF1, TIF2 TMA19 TSA2 UBA1 VMA4 VMA5 WTM1 WTM2 YNK1 YOR283W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data WTM1 Huh WK, et al. (2003)
    View Data WTM1 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [75..437] PSI-BLAST 68.69897 beta1-subunit of the signal-transducing G protein heterotrimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23969853550045 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.21305848427711 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • transporter activity
    		•  0.692270256454453 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.612501046529002 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.311523647180993 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.121183207943714 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle