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Protein Overview: AYR1

General Information:
Name(s) found: AYR1 / YIL124W [SGD]
Description(s) found:
Found 23 descriptions.
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  • NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 297 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed article]
    Biological Process: phosphatidic acid biosynthetic process [IMPLink to PubMed article]
    Molecular Function: acylglycerone-phosphate reductase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELQSQPKK IAVVTGASGG IGYEVTKELA RNGYLVYACA RRLEPMAQLA IQFGNDSIKP  60
   61 YKLDISKPEE IVTFSGFLRA NLPDGKLDLL YNNAGQSCTF PALDATDAAV EQCFKVNVFG 120
  121 HINMCRELSE FLIKAKGTIV FTGSLAGVVS FPFGSIYSAS KAAIHQYARG LHLEMKPFNV 180
  181 RVINAITGGV ATDIADKRPL PETSIYNFPE GREAFNSRKT MAKDNKPMPA DAYAKQLVKD 240
  241 ILSTSDPVDV YRGTFANIMR FVMIFVPYWL LEKGLSKKFK LDKVNNALKS KQKNKDD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADR1 ARG4 AYR1 BGL2 CBP6 COR1 CPR6 ENP1 ERG27 FAA1 GAR1 GPT2 GSP1 HEM15 HRP1 KAP104 KTR3 LIA1 MAE1 MRT4 NAB2 NDE1 OAC1 OM45 PCT1 PDA1 PET10 PET9 PIL1 PRE10 PRO3 PSD1 RET2 RNR2 RPT4 RTN2 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 TFG2 TIF34 TIF35 TPA1 VMA8 YDL063C YHM2 YNL035C YNL181W
    View Details Qiu et al. (2008) AYR1 EHT1 MCR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AYR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 230.24799 Tropinone reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • structural molecule activity
    		•  2.31813292180084 bayes_pls_golite062009
  • acylglycerone-phosphate reductase activity
    		•  1.98546853223239 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.714637370305282 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  0.62461633437589 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.233238483713519 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.192594057004213 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • DNA binding
    		•  0.0870043837215047 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.39

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle