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Protein Overview: PHO81

General Information:
Name(s) found: PHO81 / YGR233C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1178 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: phosphate metabolic process [TASLink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase inhibitor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFGKYLEAR QLELAEYNSH FIDYKALKKL IKQLAIPTLK ASSDLDLHLT LDDIDEKIIH  60
   61 QRLQENKAAF FFKLERELEK VNGYYLARES DLRIKFNILH SKYKDYKING KLNSNQATSF 120
  121 KNLYAAFKKF QKDLRNLEQY VELNKTGFSK ALKKWDKRSQ SHDKDFYLAT VVSIQPIFTR 180
  181 DGPLKLNDET LHILLELNDI DNNNRRADIQ SSTFTNDDDD DNNTSNNNKH NNNNNNNNNN 240
  241 NNNNNNNNIL HNNYELTTSK ISENQLEHLF QASSSSLDME MEIENWYKEI LNIATVKDVQ 300
  301 RKHALLRNFR ETKIFTYLLQ NSSESFHKNV FSLLKECLTT LFLLLVASPL DDNSLHIFYK 360
  361 SNQDHIDLSY CDEDDQVFSR KNVFHEAASC PEKSRLFILD EALTTSKLSK ETVQKLLNAQ 420
  421 DIHSRVPLHY AAELGKLEFV HSLLITNLLE DVDPIDSDSK TPLVLAITNN HIDVVRDLLT 480
  481 IGGANASPIE KPILDYSKNV ISSTKVQFDP LNVACKFNNH DAAKLLLEIR SKQNADNAKN 540
  541 KSSQHLCQPL FKKNSTGLCT LHIVAKIGGD PQLIQLLIRY GADPNEIDGF NKWTPIFYAV 600
  601 RSGHSEVITE LLKHNARLDI EDDNGHSPLF YALWESHVDV LNALLQRPLN LPSAPLNEIN 660
  661 SQSSTQRLNT IDLTPNDDKF DLDIQDSIPD FALPPPIIPL RKYGHNFLEK KIFIKLKLRP 720
  721 GLESIKLTQD NGIIMSSSPG RITLSSNLPE IIPRNVILPV RSGEINNFCK DISETNDEED 780
  781 DDEISEDHDD GEIIFQVDSI DDFSMDFEIF PSFGTRIIAK TTAMPFLFKK VAINSIATMN 840
  841 LPLFDTRLNN IGSLTLDYQI IFPYPGNPLK IINYEPYWKS TGSDLMTSSK DGNFVTSSSL 900
  901 NGSFISVLVC ALNDETIVAA PKPYVEFKGT KILLNDLTKE QLEKVVDYDF GKIDGSFDEV 960
  961 TLKQYLSSRV VPLRSLLEVI PGSAQLVIRV YFPTDKEIDT IPIKISPFIN INQFIDKLLL1020
 1021 IIFEHERFLR HSGSGSMRQI VFSSCNWEAC SILNWKQPNF PVLLQMKNLL RDSTTGKFVG1080
 1081 DTPNCLKELA VNPQKMSYLN TELINIHTMV QFAMNNNLLG VTLPYEVLKI CPSLARIIKQ1140
 1141 NGLLLIASVG ENDQIPADGG YSGIYYACEL LFENNIDM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PHO80 PHO81 PHO85
    View Details Krogan NJ, et al. (2006) PHO80 PHO81
    View Details Gavin AC, et al. (2006) CYR1 PHO81 SRV2
    View Details Gavin AC, et al. (2002) ACT1 CYR1 PHO81 SRV2
    View Details Ho Y, et al. (2002) AAC3 ADK1 AGX1 AIP1 BUD32 CAR2 COF1 CPR6 CRM1 CYR1 DIA4 EMG1 GCN1 GRX3 GRX4 HEF3 IDP2 IMD2 IMD4 KAE1 KAP114 NPA3 PCL7 PHO81 PHO85 REX2 RNH202 RPN1 RPN5 RPN6 RPT1 SEC18 SEC23 SGO1 SOD1 SRV2 TMA29 TOS3 URA7 YHB1 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run MIH1 experimental1 - mih1-1 McCusker D, et al (2007)
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPT21 PHO81 1 Unpublished Fields Lab Data
    View Screen RAD1 PHO81 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PHO81 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] Pfam 53.585027 SPX domain No confident structure predictions are available.
    2 View Details [176..243] deduced N/A No confident structure predictions are available.
    3 View Details [244..419] ORFEUS 7.62 Hemolysin E (HlyE, ClyA, SheA)
    4 View Details [420..551] PSI-BLAST 109.228787 bcl-3
    5 View Details [552..695] PSI-BLAST 109.228787 bcl-3
    6 View Details [696..948] MSA 1.463992 View MSA. No confident structure predictions are available.
    7 View Details [949..1178] MSA 8.053994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.25164755703631 bayes_pls_golite062009
  • protein binding
    		•  1.59457752054553 bayes_pls_golite062009
  • protein kinase activity
    		•  0.365185410094788 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.245542867909649 bayes_pls_golite062009
  • kinase activity
    		•  0.194495818183408 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.190407604407951 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • phosphoric ester hydrolase activity
    		•  2.13191784643678 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.51527480538766 bayes_pls_golite062009
  • binding
    		•  1.35961497708543 bayes_pls_golite062009
  • catalytic activity
    		•  1.14265621143219 bayes_pls_golite062009
  • protein binding
    		•  0.344856803057979 bayes_pls_golite062009
  • hydrolase activity
    		•  0.269155784613721 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle