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View Structure Prediction Details

Protein: PHO81
Organism: Saccharomyces cerevisiae
Length: 1178 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO81.

Description E-value Query
Range
Subject
Range
PHO81 - Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complex...
PHO81_YEAST - Phosphate system positive regulatory protein PHO81 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
0.0 [1..1178] [1..1178]
ANK2 - ankyrin 2, neuronal
0.0 [126..922] [38..814]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [126..968] [48..868]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
0.0 [111..942] [4..806]

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Predicted Domain #1
Region A:
Residues: [1-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFGKYLEAR QLELAEYNSH FIDYKALKKL IKQLAIPTLK ASSDLDLHLT LDDIDEKIIH  60
   61 QRLQENKAAF FFKLERELEK VNGYYLARES DLRIKFNILH SKYKDYKING KLNSNQATSF 120
  121 KNLYAAFKKF QKDLRNLEQY VELNKTGFSK ALKKWDKRSQ SHDKDFYLAT VVSIQ

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 53.585027
Match: PF03105
Description: SPX domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [176-243]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIFTRDGPLK LNDETLHILL ELNDIDNNNR RADIQSSTFT NDDDDDNNTS NNNKHNNNNN  60
   61 NNNNNNNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [244-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNNILHNN YELTTSKISE NQLEHLFQAS SSSLDMEMEI ENWYKEILNI ATVKDVQRKH  60
   61 ALLRNFRETK IFTYLLQNSS ESFHKNVFSL LKECLTTLFL LLVASPLDDN SLHIFYKSNQ 120
  121 DHIDLSYCDE DDQVFSRKNV FHEAASCPEK SRLFILDEAL TTSKLSKETV QKLLNA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.62
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.25164755703631 bayes_pls_golite062009
protein binding 1.59457752054553 bayes_pls_golite062009
protein kinase activity 0.365185410094788 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.245542867909649 bayes_pls_golite062009
kinase activity 0.194495818183408 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.190407604407951 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [420-551]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDIHSRVPLH YAAELGKLEF VHSLLITNLL EDVDPIDSDS KTPLVLAITN NHIDVVRDLL  60
   61 TIGGANASPI EKPILDYSKN VISSTKVQFD PLNVACKFNN HDAAKLLLEI RSKQNADNAK 120
  121 NKSSQHLCQP LF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.228787
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [552-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKNSTGLCTL HIVAKIGGDP QLIQLLIRYG ADPNEIDGFN KWTPIFYAVR SGHSEVITEL  60
   61 LKHNARLDIE DDNGHSPLFY ALWESHVDVL NALLQRPLNL PSAPLNEINS QSSTQRLNTI 120
  121 DLTPNDDKFD LDIQDSIPDF ALPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.228787
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoric ester hydrolase activity 2.13191784643678 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.51527480538766 bayes_pls_golite062009
binding 1.35961497708543 bayes_pls_golite062009
catalytic activity 1.14265621143219 bayes_pls_golite062009
protein binding 0.344856803057979 bayes_pls_golite062009
hydrolase activity 0.269155784613721 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [696-948]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PIIPLRKYGH NFLEKKIFIK LKLRPGLESI KLTQDNGIIM SSSPGRITLS SNLPEIIPRN  60
   61 VILPVRSGEI NNFCKDISET NDEEDDDEIS EDHDDGEIIF QVDSIDDFSM DFEIFPSFGT 120
  121 RIIAKTTAMP FLFKKVAINS IATMNLPLFD TRLNNIGSLT LDYQIIFPYP GNPLKIINYE 180
  181 PYWKSTGSDL MTSSKDGNFV TSSSLNGSFI SVLVCALNDE TIVAAPKPYV EFKGTKILLN 240
  241 DLTKEQLEKV VDY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [949-1178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFGKIDGSFD EVTLKQYLSS RVVPLRSLLE VIPGSAQLVI RVYFPTDKEI DTIPIKISPF  60
   61 ININQFIDKL LLIIFEHERF LRHSGSGSMR QIVFSSCNWE ACSILNWKQP NFPVLLQMKN 120
  121 LLRDSTTGKF VGDTPNCLKE LAVNPQKMSY LNTELINIHT MVQFAMNNNL LGVTLPYEVL 180
  181 KICPSLARII KQNGLLLIAS VGENDQIPAD GGYSGIYYAC ELLFENNIDM 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle