Protein Overview: SWI5

General Information:
Name(s) found:	SWI5 / YDR146C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|899396\|emb\|CAA90369.1\| Swi5p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|TWBYS5 transcription factor SWI5 [validated] - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6320350\|ref\|NP_010430.1\| Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; Swi5 [NCBI NR] gi\|4596\|emb\|CAA30040.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|135077\|sp\|P08153.1\|SWI5_YEAST RecName: Full=Transcriptional factor SWI5 [NCBI NR] Transcriptional factor SWI5 OS=Saccharomyces cerevisiae GN=SWI5 PE=1 SV=1 [Swiss-Prot] SWI5 Transcription factor [mips] Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase [SGD] SWI5, Chr IV from 748606-750735, reverse complement [yeast_orfs2] Chr IV from 748606-750735, reverse complement [yeastorf3.fasta] Chr IV from 750735-748606, reverse complement [yeastorf5.fasta] (P08153) Transcriptional factor SWI5 [4932.FASTACCERV.txt] SWI5 SGDID:S0002553, Chr IV from 750736-748607, reverse complement, Verified ORF [yeastflysequest.fasta] SWI5 SGDID:S0002553, Chr IV from 750737-748608, reverse complement, Verified ORF [10112005cervSGD.fasta] Swi5p [Saccharomyces cerevisiae]gi\|4596\|emb\|CAA30040.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|899396\|emb\|CAA90369.1\| Swi5p [Saccharomyces cerevisiae]gi\|72898\|pir\|\|TWBYS5 transcription factor SWI5 [validated] - yeast (Saccharomyces cerevi [nrdb_11152004_Chlamydomonas] SWI5 SGDID:S000002553, Chr IV from 750737-748608, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed in G1 phase and at the G1/M boundary; localization to the nucleus occurs during G1 and appears to be [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SWI5 SGDID:S000002553, Chr IV from 750739-748610, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed in G1 phase and at the G1/M boundary; localization to the nucleus occurs during G1 and appears to be [yeast-contam.fasta] SWI5 SGDID:S000002553, Chr IV from 750740-748611, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Swi5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Transcriptional factor SWI5 [nr-271106-contam.fasta] Transcription factor that activates transcription of genes expressed in G1 phase and at the G1/M boundary; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; Swi5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SWI5 SGDID:S000002553, Chr IV from 750740-748611, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase" [yeast-bovrabprots.fasta] SWI5 SGDID:S000002553, Chr IV from 750739-748610, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed in G1 phase and at the G1/M boundary; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase" [yeast-contam_custom.fasta] [chemostatdb.fasta] Transcriptional factor SWI5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWI5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SWI5 SGDID:S000002553, Chr IV from 750742-748613, Genome Release 64-1-1, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase" [yeast-030211-contam.fasta] SWI5 SGDID:S000002553, Chr IV from 750742-748613, Genome Release 64-2-1, reverse complement, Verified ORF, "Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR1548\|c0_g1_i1\|g.1162 ORF TR1548\|c0_g1_i1\|g.1162 TR1548\|c0_g1_i1\|m.1162 type:complete len:710 (+) TR1548\|c0_g1_i1:623-2752(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR442\|c0_g1_i1\|g.341 ORF TR442\|c0_g1_i1\|g.341 TR442\|c0_g1_i1\|m.341 type:complete len:710 (+) TR442\|c0_g1_i1:649-2778(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YDR146C SGDID:S000002553, Chr IV from 750742-748613, Genome Release 64-1-1, reverse complement, Verified ORF, "Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_289\|g.642 ORF asmbl_289\|g.642 asmbl_289\|m.642 type:complete len:710 (+) asmbl_289:672-2801(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_887\|g.386 ORF ID=asmbl_887\|g.386 ID=asmbl_887\|m.386 type:complete len:710 (+) ID=asmbl_887:649-2778(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	709 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	regulation of transcription involved in G1 phase of mitotic cell cycle [IDA]
Molecular Function:	transcription activator activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTSNSWFDA SKVQSLNFDL QTNSYYSNAR GSDPSSYAIE GEYKTLATDD LGNILNLNYG  60
   61 ETNEVIMNEI NDLNLPLGPL SDEKSVKVST FSELIGNDWQ SMNFDLENNS REVTLNATSL 120
  121 LNENRLNQDS GMTVYQKTMS DKPHDEKKIS MADNLLSTIN KSEINKGFDR NLGELLLQQQ 180
  181 QELREQLRAQ QEANKKLELE LKQTQYKQQQ LQATLENSDG PQFLSPKRKI SPASENVEDV 240
  241 YANSLSPMIS PPMSNTSFTG SPSRRNNRQK YCLQRKNSSG TVGPLCFQEL NEGFNDSLIS 300
  301 PKKIRSNPNE NLSSKTKFIT PFTPKSRVSS ATSNSANITP NNLRLDFKIN VEDQESEYSE 360
  361 KPLGLGIELL GKPGPSPTKS VSLKSASVDI MPTIPGSVNN TPSVNKVSLS SSYIDQYTPR 420
  421 GKQLHFSSIS ENALGINAAT PHLKPPSQQA RHREGVFNDL DPNVLTKNTD NEGDDNEENE 480
  481 PESRFVISET PSPVLKSQSK YEGRSPQFGT HIKEINTYTT NSPSKITRKL TTLPRGSIDK 540
  541 YVKEMPDKTF ECLFPGCTKT FKRRYNIRSH IQTHLEDRPY SCDHPGCDKA FVRNHDLIRH 600
  601 KKSHQEKAYA CPCGKKFNRE DALVVHRSRM ICSGGKKYEN VVIKRSPRKR GRPRKDGTSS 660
  661 VSSSPIKENI NKDHNGQLMF KLEDQLRRER SYDGNGTGIM VSPMKTNQR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ARP4 FAA2 HFI1 RPO31 SPT7 STB4 SWC4 SWI5 TRA1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SWI5	MEI5	2	Unpublished Fields Lab Data
View Screen	SWI5	YCR087W	2	Unpublished Fields Lab Data
View Screen	SWI5	NCE101	2	Unpublished Fields Lab Data
View Screen	SWI5	PTC4	1	Unpublished Fields Lab Data
View Screen	SWI5	GCN2	1	Unpublished Fields Lab Data
View Screen	SWI5	PDX1	1	Unpublished Fields Lab Data
View Screen	SWI5	MSA2	1	Unpublished Fields Lab Data
View Screen	SWI5	RPB2	1	Unpublished Fields Lab Data
View Screen	SWI5	RPB5	1	Unpublished Fields Lab Data
View Screen	SWI5	SPT3	1	Unpublished Fields Lab Data
View Screen	SWI5	YGR293C	1	Unpublished Fields Lab Data
View Screen	SWI5	TPO1	1	Unpublished Fields Lab Data
View Screen	SWI5	YOR169C	1	Unpublished Fields Lab Data
View Screen	SWI5	MCM7	1	Unpublished Fields Lab Data
View Screen	SWI5	YEL073C	1	Unpublished Fields Lab Data
View Screen	SWI5	CIC1	1	Unpublished Fields Lab Data
View Screen	SWI5	YLR042C	1	Unpublished Fields Lab Data
View Screen	SWI5	GEP3	1	Unpublished Fields Lab Data
View Screen	SWI5	ARC40	1	Unpublished Fields Lab Data
View Screen	SWI5	TPA1	1	Unpublished Fields Lab Data
View Screen	SWI5	IMP3	1	Unpublished Fields Lab Data
View Screen	SWI5	YSH1	1	Unpublished Fields Lab Data
View Screen	SWI5	YOR277C	1	Unpublished Fields Lab Data
View Screen	SWI5	NFS1	1	Unpublished Fields Lab Data
View Screen	SWI5	YER097W	1	Unpublished Fields Lab Data
View Screen	SWI5	RPN10	1	Unpublished Fields Lab Data
View Screen	SWI5	YLR419W	1	Unpublished Fields Lab Data
View Screen	SWI5	ERR1, ERR2	1	Unpublished Fields Lab Data
View Screen	SWI5	YCL042W	1	Unpublished Fields Lab Data
View Screen	SWI5	RTT105	1	Unpublished Fields Lab Data
View Screen	SWI5	FLO5	1	Unpublished Fields Lab Data
View Screen	SWI5	VPS71	1	Unpublished Fields Lab Data
View Screen	SWI5	GPI2	1	Unpublished Fields Lab Data
View Screen	SWI5	MATALPHA1, HMLALPHA1	1	Unpublished Fields Lab Data
View Screen	SWI5	GLC7	1	Unpublished Fields Lab Data
View Screen	SWI5	AIR1	1	Unpublished Fields Lab Data
View Screen	SWI5	UTP14	1	Unpublished Fields Lab Data
View Screen	SWI5	HMLALPHA2, MATALPHA2	1	Unpublished Fields Lab Data
View Screen	SWI5	SCC4	1	Unpublished Fields Lab Data
View Screen	SWI5	AIM20	1	Unpublished Fields Lab Data
View Screen	SWI5	ZDS2	1	Unpublished Fields Lab Data
View Screen	SWI5	AIM44	1	Unpublished Fields Lab Data
View Screen	SWI5	RRT12	1	Unpublished Fields Lab Data
View Screen	SWI5	ADK2	1	Unpublished Fields Lab Data
View Screen	SWI5	SSY5	1	Unpublished Fields Lab Data
View Screen	SWI5	GTR1	1	Unpublished Fields Lab Data
View Screen	SWI5	BEM4	1	Unpublished Fields Lab Data
View Screen	SWI5	YFL012W	1	Unpublished Fields Lab Data
View Screen	SWI5	SET2	1	Unpublished Fields Lab Data
View Screen	SWI5	DYN3	1	Unpublished Fields Lab Data
View Screen	SWI5	REV3	1	Unpublished Fields Lab Data
View Screen	SWI5	FLO9	1	Unpublished Fields Lab Data
View Screen	SWI5	YDL118W	1	Unpublished Fields Lab Data
View Screen	SWI5	YFH7	1	Unpublished Fields Lab Data
View Screen	SWI5	YNL050C	1	Unpublished Fields Lab Data
View Screen	SWI5	HFI1	1	Unpublished Fields Lab Data
View Screen	SWI5	SWH1	1	Unpublished Fields Lab Data
View Screen	SWI5	VCX1	1	Unpublished Fields Lab Data
View Screen	SWI5	PRM8	1	Unpublished Fields Lab Data
View Screen	SWI5	HUL4	1	Unpublished Fields Lab Data
View Screen	SWI5	OCA1	1	Unpublished Fields Lab Data
View Screen	SWI5	YPR091C	1	Unpublished Fields Lab Data
View Screen	SWI5	PHO11	1	Unpublished Fields Lab Data
View Screen	SWI5	CDC34	1	Unpublished Fields Lab Data
View Screen	SWI5	AIM14	1	Unpublished Fields Lab Data
View Screen	SWI5	YJR056C	1	Unpublished Fields Lab Data
View Screen	SWI5	AAH1	1	Unpublished Fields Lab Data
View Screen	SWI5	YTH1	1	Unpublished Fields Lab Data
View Screen	SWI5	YMC2	1	Unpublished Fields Lab Data
View Screen	SWI5	ALT2	1	Unpublished Fields Lab Data
View Screen	SWI5	YGR012W	1	Unpublished Fields Lab Data
View Screen	SWI5	UGP1	1	Unpublished Fields Lab Data
View Screen	SWI5	YOL035C	1	Unpublished Fields Lab Data
View Screen	SWI5	BET2	1	Unpublished Fields Lab Data
View Screen	SWI5	AIM3	1	Unpublished Fields Lab Data
View Screen	SWI5	SEC7	1	Unpublished Fields Lab Data
View Screen	SWI5	YGR107W	1	Unpublished Fields Lab Data
View Screen	SWI5	MDH1	1	Unpublished Fields Lab Data
View Screen	SWI5	VAM3	1	Unpublished Fields Lab Data
View Screen	ALG13	SWI5	1	Hazbun TR, et al. (2003)
View Screen	SWI5	TFC1	1	Unpublished Fields Lab Data
View Screen	SWI5	NUP42	1	Unpublished Fields Lab Data
View Screen	SWI5	YGR164W	1	Unpublished Fields Lab Data
View Screen	SWI5	YKL102C	1	Unpublished Fields Lab Data
View Screen	SWI5	YOR114W	1	Unpublished Fields Lab Data
View Screen	NAF1	SWI5	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SWI5	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..74]	deduced	N/A	Confident ab initio structure predictions are available.
2	View Details	[75..182]	MSA	42.524997	View MSA. No confident structure predictions are available.
3	View Details	[183..298]	MSA	6.848995	View MSA. No confident structure predictions are available.
4	View Details	[299..359]	PSI-BLAST	3.69897	Enhancer binding protein
5	View Details	[360..477]	MSA	2.961995	View MSA. No confident structure predictions are available.
6	View Details	[478..584]	PSI-BLAST	126.228787	Five-finger GLI1
7	View Details	[585..709]	PSI-BLAST	117.39794	Designed zinc finger protein

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
nucleic acid binding	2.36376512665406	bayes_pls_golite062009
DNA binding	2.2458683155586	bayes_pls_golite062009
binding	2.05464920186799	bayes_pls_golite062009
protein binding	0.476896736636797	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2